Senior/Principal Research Associate Research, Mass Spectrometry and Proteomics
2 months ago
Flare Therapeutics is a biotechnology company pioneering a new therapeutic space with a novel approach to decipher the biology of transcription factors to develop small molecule medicines. Based on insights from the seminal work of its scientific founders, Flare's team has uncovered 'switch sites,' druggable regions that are key targets for transcription factor regulation, to address mutations that cause disease. Flare's drug discovery efforts to target switch sites has rapidly advanced, resulting in an emerging pipeline of research programs that address well-validated genetically-defined transcription factors, initially focused on precision oncology with future potential in neurology, rare genetic disorders, immunology and inflammation.
We are a collective of brilliant fires, trailblazing a path to conquer transcription factors and create cutting-edge medicines for patients. We embrace diversity in all its forms, experiences, and viewpoints. We are inspired by the unknown and willing to take risks. We are passionate about the science we pursue and compassionate about the patients it stands to benefit. And we respect, value, and believe in each other.
In this role you will...
- Execute experiments to inform target engagement on transcription factors using a variety of approaches which include tissue cell culture, automated workflows and characterization using mass-spectrometry based proteomics
- Execute high-throughput global proteomics characterization of transcription factors using isotope labeling, TMT, alternative proteases, targeted proteomics (PRM or equivalent) and data-independent acquisition (DIA) workflows
- Generate data in a timely manner; support lead discovery initiatives and regularly contribute at the bench
- Work closely with senior staff to set experimental strategy, project goals, and timelines to drive projects toward successful completion
- Work closely with biology, biochemistry, chemistry and compound management teams in early discovery to optimize screening on high-value transcription factors
About you...
- You have a B.S or M.S in chemical biology, biochemistry or analytical chemistry
- You have 1-3 years of experience in industry
- You have knowledge of proteomics principles and hands-on experience in mass spectrometry-based quantitative proteomics that includes DDA, DIA and/or LFQ
- You may have experience in targeted proteomics and TMT-based workflows
- You may also have understanding of proteomics sample preparations using both 96- and 384-well plate formats
- You may have prior experience with assay development, sample prep automation, HPLC fractionation
- You have a desire to work in a lab-based role within a highly adaptive, fast-paced collaborative environment and can creatively solve problems through innovation and communication
- You have self-motivation, great decision making, organizational, analytical, interpersonal and communication skills
Flare Therapeutics is proud to foster a diverse, equitable and inclusive company culture that embraces all people that are essential to who we are, what we do and what we believe. Flare Therapeutics is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.
TO ALL AGENCIES: Please, no phone calls or emails to any employee of Flare Therapeutics about our openings. All resumes submitted by search firms/employment agencies to any employee at Flare Therapeutics via email, the internet or in any form and/or method will be deemed the sole property of Flare Therapeutics, unless such search firms/employment agencies were engaged by Flare Therapeutics for this position and a valid agreement with Flare Therapeutics is in place. In the event a candidate who was submitted outside of the Flare Therapeutics agency engagement process is hired, no fee or payment of any kind will be paid.
-
Scientist I/II, Mass Spectrometry and Proteomics
1 month ago
Cambridge, Massachusetts, United States Flare Therapeutics Full timeFlare Therapeutics is a biotechnology company pioneering a new therapeutic space with a novel approach to decipher the biology of transcription factors to develop small molecule medicines. Based on insights from the seminal work of its scientific founders, Flare's team has uncovered 'switch sites,' druggable regions that are key targets for transcription...
-
Cambridge, Massachusetts, United States Flagship Pioneering Full timeJob Summary:We are seeking a highly skilled Senior Researcher/Principal Research Scientist to join our team at Flagship Pioneering. As a key member of our biomarker discovery and data science team, you will play a crucial role in shaping our preclinical platform and addressing diseases before they become a burden to patients and healthcare systems.Key...
-
Cambridge, Massachusetts, United States FogPharma Full timeAbout the Role:FogPharma is a pioneering biopharmaceutical company that is revolutionizing the medical possibilities for patients by precisely drugging intracellular targets. As a Senior/Principal Associate Scientist, you will play a key role in our high-throughput multiplexed screening platform, which combines protein biochemistry, combinatorial chemistry,...
-
Director, Mass Spectrometry
3 months ago
Cambridge, Massachusetts, United States Moderna, Inc. Full timeThe Role:We are seeking a talented, motivated and proven scientific leader to expand our capabilities and capacity for mass spectrometry (MS) and immunopeptidomic work flows across discovery and pre-clinical Cancer Vaccine Research (CVR) initiatives. The successful candidate will be a technical expert and recognized leader in the MS/immunopeptidomics field...
-
Senior Research Associate
6 days ago
Cambridge, Massachusetts, United States Mass General Brigham Full timeAbout the RoleWe are seeking a highly skilled Research Fellow to join our team at Mass General Brigham. As a key member of our AbuGoot Lab, you will be responsible for conducting cutting-edge research in molecular biology, protein design, and biotechnology.Key ResponsibilitiesDesign and execute molecular cloning experiments to develop novel protein-based...
-
Research Associate
3 days ago
Cambridge, Massachusetts, United States Strand Research Full timeAbout the RoleWe are seeking a highly skilled Research Associate to join our team at Strand Research. As a key member of our research team, you will be responsible for conducting mechanical testing of coatings for biological applications.Key Responsibilities:Secure and maintain biological materials according to research needsOperate mechanical and analytical...
-
Cambridge, Massachusetts, United States Novartis Group Companies Full timeJob Description SummaryWe are seeking a highly motivated and experienced individual to join our team as a Principal Scientist with expertise in advanced spatial proteomics. This role involves working with cutting-edge technology, collaborating with translational immunologists, cancer biologists, and other researchers to advance our understanding of cellular...
-
Research Scientist DoM AbuGoot Lab
3 days ago
Cambridge, Massachusetts, United States Mass General Brigham Full timeJob SummaryWe are seeking a highly skilled Research Fellow to join our team at Mass General Brigham. As a Research Fellow, you will be responsible for conducting molecular cloning, protein design, bacterial assays, mammalian cell culture, directed evolution, and animal work.Key ResponsibilitiesConduct molecular cloning and protein design experimentsPerform...
-
Cambridge, Massachusetts, United States Novartis Group Companies Full timeAbout the RoleWe are seeking a highly motivated individual passionate about cutting-edge technology to explore single cell multiplex spatial proteomics. This role involves working with the latest generation PhenoCycler Fusion instrument and collaborating with translational immunologists, cancer biologists, and other researchers to advance our understanding...
-
Principal Research Associate, Chemistry
1 month ago
Cambridge, Massachusetts, United States Moderna, Inc. Full timeThe Role:Moderna is seeking a highly qualified and motivated Principal Research Associate to help evolve Modernas proprietary mRNA delivery platforms. The ideal candidate for this role will be responsible for the timely synthesis, purification, and characterization of project compounds, and will be expected to regularlypresent findings and project updates to...
-
Senior Principal Scientist
3 days ago
Cambridge, Massachusetts, United States Novartis Group Companies Full timeJob SummaryAs a Senior Principal Scientist in the Translational Medicine Drug Disposition Bioanalytical group at Novartis Group Companies, you will have the opportunity to make a significant impact in the development of novel modality biologics. This vital leadership role requires a collaborative nature, a commitment to teamwork, and a relentless focus on...
-
Cambridge, Massachusetts, United States Novartis Farmacéutica Full timeAbout the RoleWe are seeking a highly motivated and experienced individual to join our team as a Principal Scientist with expertise in advanced spatial proteomics. The successful candidate will have a strong background in immunology, biological sciences, or a related field, and a proven track record of using cutting-edge technologies such as the PhenoCycler...
-
Senior Scientist, Chemical Biology
2 months ago
Cambridge, Massachusetts, United States Merck Full timeJob DescriptionOur company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and consumer health products, as well as animal health products. Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us. Our ability to excel depends on the...
-
Research Associate
4 days ago
Cambridge, Massachusetts, United States Strand Research Full timeAbout Strand ResearchWe are a biotechnology startup dedicated to developing and optimizing novel molecules for consumer applications, with a primary focus on hair. Our mission is to address the most significant challenges in hair care faced by consumers today.ResponsibilitiesOperate and execute biophysical, biochemical, and analytical assays using...
-
In Vivo Research Specialist
2 weeks ago
Cambridge, Massachusetts, United States Mass General Brigham Full timePosition Overview We are seeking a dedicated In Vivo Research Specialist to lead our rodent malaria research initiatives. This role involves overseeing the management of Plasmodium frozen stocks for mosquito infection studies. Key Responsibilities Monitor Mosquito Infection Status: Assess blood feeding, natural transmission, and conduct parasite...
-
Cambridge, Massachusetts, United States Mass General Brigham Full timeJob SummaryWe are seeking a highly motivated and experienced Postdoctoral Researcher to join our team at Mass General Brigham. The successful candidate will have a strong background in immunology, biotechnology, or a related field and will be responsible for designing and executing scientific projects related to antibody discovery and development.Key...
-
Educational Research Scientist
2 weeks ago
Cambridge, Massachusetts, United States Society for Learning Analytics Research Full timePosition Overview:The Society for Learning Analytics Research is seeking a dedicated Educational Research Scientist to join our innovative team. This role focuses on exploring effective learning methodologies and enhancing educational experiences through technology integration.Key Responsibilities:As a vital member of our collaborative research team, you...
-
Cambridge, Massachusetts, United States Novartis Group Companies Full timePosition OverviewJoin our team as a Senior Principal Scientist within the Translational Medicine Drug Disposition Bioanalytical division. This role offers a unique opportunity to enhance your leadership capabilities while contributing to our mission of improving patient outcomes. We seek individuals who thrive in collaborative environments and are dedicated...
-
Postdoctoral Researcher
2 days ago
Cambridge, Massachusetts, United States Harvard University Full timeAbout the PositionThe Digital, Data, and Design Institute at Harvard University is seeking a highly skilled Postdoctoral Fellow to join our team for the 2024-2025 academic year. As a Postdoctoral Fellow, you will work closely with our faculty Principal Investigators and the Senior Director of Labs to conduct research activities in the Laboratory for...
-
Spatial Transcriptomics Research Scientist
2 weeks ago
Cambridge, Massachusetts, United States Massachusetts Institute of Technology Full timePosition: Research Scientist, Chung LabInstitution: Massachusetts Institute of TechnologyOverview:The Chung Lab at the Picower Institute for Learning and Memory is seeking a dedicated Research Scientist to play a crucial role in the acquisition of spatial transcriptomic and proteomic optical imaging data from both human and non-human primate brains. This...
