We have other current jobs related to this field that you can find below
-
Scientist I
4 weeks ago
Boston, Massachusetts, United States Harvard University Full timeHarvard UniversityPosition Title: Scientist I - Bone Marrow Chips in SpaceReq ID: 66588BRSchool or Unit: Wyss Institute at Harvard UniversityDescription: Job SummaryThe Wyss Institute is seeking a Scientist I to create and analyze human Bone Marrow Chips that will fly alongside astronaut crewmembers on upcoming lunar space missions. The project's objectives...
-
Scientist I
3 weeks ago
Boston, Massachusetts, United States Dana-Farber Cancer Institute Full timeScientist IDana-Farber Cancer InstituteBoston, MA – Hybrid (2-3 days onsite/week)Full TimeThe Division of Population Sciences is seeking a Research Scientist with a background in cancer epidemiology, statistics, or genetics, and interest in cancer early detection.This position will report directly to Dr. Sapna Syngal and work as part of both Genetics and...
-
Computational Research Scientist I, Neurosurgery
12 hours ago
Boston, Massachusetts, United States Brigham and Women's Hospital Full timeJob Title: Computational Research Scientist I, NeurosurgeryCompany: Brigham and Women's HospitalRequirements:• Bachelor's Degree in Computer Science, Engineering, Physics, or related field.• Prior experience in computational biology, statistics, deep learning algorithms, or genetics is highly valued.• We seek a candidate with strong attention to...
-
Associate Scientist
3 weeks ago
Boston, Massachusetts, United States Takeda Full timeBy clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda'sPrivacy Noticeand Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.Job...
-
Sr. Scientist
2 months ago
Boston, Massachusetts, United States Thermo Fisher Scientific Full timeWork ScheduleOtherEnvironmental ConditionsOfficeJob DescriptionAt Thermo Fisher Scientific, you'll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier, cleaner and safer. We provide our teams with the resources needed to achieve...
-
Associate Scientist
1 month ago
Boston, Massachusetts, United States Thermo Fisher Scientific Full timeWork ScheduleStandard (Mon-Fri)Environmental ConditionsAdherence to all Good Manufacturing Practices (GMP) Safety StandardsJob DescriptionAt Thermo Fisher Scientific, you'll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier, cleaner...
-
Scientist I, Downstream CMC
4 weeks ago
Boston, Massachusetts, United States Entrada Therapeutics Full timeThe OrganizationWhat's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible.Our Endosomal Escape Vehicle (EEVTM)-therapeutics are designed to enable the efficient...
-
Computational Scientist, Protein Library Design
2 months ago
Boston, Massachusetts, United States Manifold Bio Full timeManifold Bio is a biotech company pursuing a pipeline of protein therapeutics using novel molecular measurement technologies and library-guided protein engineering.Our drug discovery engine is differentiated by massively parallel screening in vivo from the beginning of our discovery process.We combine this and other high-throughput protein engineering...
-
Principal Scientist, Preclinical Pharmacology
3 weeks ago
Boston, Massachusetts, United States OSI Full timePrincipal Scientist, Preclinical PharmacologyPosition SummaryPepGen is seeking a highly motivated and innovative Principal Scientist to join the Preclinical Research and Development group in Boston, Massachusetts. We are looking for a senior scientist who brings enthusiasm, curiosity, scientific rigor, and a desire to transform the future of neuromuscular...
-
Junior Analytical Scientist
6 days ago
Boston, Massachusetts, United States Elektrofi Inc Full timeJob OverviewABOUT ELEKTROFIElektrofi is at the forefront of transforming the administration of biologic therapies, empowering patients with the choice of how they receive essential medications. Our innovative ultra-high concentration microparticle technology addresses the challenges associated with traditional intravenous biologic therapies, facilitating...
-
Biotech Field Scientist
6 days ago
Boston, Massachusetts, United States Unchained Labs Full timeJob OverviewApplications Scientist - Life SciencesAre you passionate about advancing scientific research? We are seeking a dedicated Applications Scientist to join our innovative team. In this role, you will leverage your expertise in Biochemistry or Biophysical sciences to enhance our sales and customer support efforts for cutting-edge life sciences tools....
-
Associate Scientist
1 month ago
Boston, Massachusetts, United States Thermo Fisher Scientific Full timeWork ScheduleStandard (Mon-Fri)Environmental ConditionsAdherence to all Good Manufacturing Practices (GMP) Safety StandardsJob DescriptionAt Thermo Fisher Scientific, you'll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier, cleaner...
-
Associate Scientist
2 months ago
Boston, Massachusetts, United States Thermo Fisher Scientific Full timeWork ScheduleEnvironmental ConditionsJob DescriptionAt Thermo Fisher Scientific, you'll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier, cleaner and safer. We provide our teams with the resources needed to achieve individual...
-
Senior Analytical Chemist I, Metabolomics
1 month ago
Boston, Massachusetts, United States Ginkgo Bioworks Full timeFull Time] Senior Analytical Chemist I, Metabolomics at Ginkgo Bioworks (United States) | BEAMSTART JobsSenior Analytical Chemist I, MetabolomicsWe are seeking a metabolomics scientist who will be a key contributor in the area of Natural Product Chemistry in the Chemistry group and provide expertise in the area of Metabolomics and Mass Spectrometry based...
-
Associate Scientist
2 months ago
Boston, Massachusetts, United States Thermo Fisher Scientific Full timeWork ScheduleStandard (Mon-Fri)Environmental ConditionsAdherence to all Good Manufacturing Practices (GMP) Safety StandardsJob DescriptionAt Thermo Fisher Scientific, you'll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier, cleaner...
-
Research Lab Manager BWH Neurology
1 month ago
Boston, Massachusetts, United States Brigham & Women's Hospital(BWH) Full timeThe Renthal Lab at Brigham and Women's Hospital and Harvard Medical School is seeking a highly motivated scientist to join our efforts to understand the genomic and epigenomic mechanisms that establish neuronal identity and how these processes contribute to nerve repair after injury. Our long-term vision is to leverage these molecular insights to build new...
-
Laboratory Manager- Sankaran Lab
4 weeks ago
Boston, Massachusetts, United States Howard Hughes Medical Institute (HHMI) Full timeWe have an outstanding opportunity for an experienced Laboratory Manager to join the Sankaran lab at Boston Children's Hospital. The Sankaran Laboratory uses human genetics to study hematopoiesis and how this process goes awry in human disease. We are particularly interested in gaining molecular insights into how hematopoietic stem and progenitor cells can...
-
Research Scientist, Cancer Center
1 month ago
Boston, Massachusetts, United States Massachusetts General Physicians Organization Full timeJob Description – Research Scientist, Cancer Center ()Unique opportunity to join an interdisciplinary team at the Krantz Family Center for Cancer Research at the Massachusetts General Hospital. The Lawrence Lab seeks an experienced candidate to join a team of computational biologists working at the forefront of cancer research and treatment. We use...
-
Chemical Biology Staff Scientist I/II
5 days ago
Boston, Massachusetts, United States Kojin Therapeutics Full timeAbout Kojin TherapeuticsKojin Therapeutics, Inc. is at the forefront of pioneering advancements in cell-state and ferroptosis biology, dedicated to creating groundbreaking therapies for a range of conditions, including various cancers, cardiovascular issues, immunological disorders, liver diseases, and degenerative ailments. Our organization, inspired by the...
-
Associate Scientist
1 month ago
Boston, Massachusetts, United States Thermo Fisher Scientific Full timeWork ScheduleStandard (Mon-Fri)Environmental ConditionsAdherence to all Good Manufacturing Practices (GMP) Safety StandardsJob DescriptionAt Thermo Fisher Scientific, you'll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier, cleaner...
![Dana-Farber Cancer Institute (DFCI)](https://contents.bebee.com/companies/us/danafarber-cancer-institute-dfci/avatar-Yc8tX.png)
Scientist I – Lindsley Lab
2 months ago
Scientist I – Lindsley Lab
Dana-Farber Cancer Institute
Boston, MA
Full Time
A Research Scientist position is available in the laboratory of Dr. Coleman Lindsley ) at the Dana-Farber Cancer Institute (DFCI) and Harvard Medical School. We use interdisciplinary approaches at the interface of genomics and molecular biology to understand the mechanisms of human disease, with the aim of translating these insights into novel therapies for patients with cancer.
This position will involve studying the mechanisms by which epigenetic dysregulation promotes development of leukemia, with an emphasis on the Polycomb repressive complex function (PRC). This lab-based research effort builds on our clinical discoveries linking PRC1.1 inactivation to poor prognosis and differential response to standard and novel treatments and our mechanistic studies describing how specific gene mutations disrupt PRC1.1 complex assembly to impair repressive function and drive epigenetic reprogramming of leukemia target genes that mediate oncogenic signaling.
Responsibilities
The Research Scientist will be engaged in basic and translational studies supporting a range of projects, including:
- Defining the role of PRC1.1 in normal and malignant hematopoiesis using mouse models,
- Understanding the kinetics and dynamics of epigenetic changes following PRC1.1 disruption using targeted protein degradation models.
- Determining the influence of co-occurring gene mutations in RNA splicing and transcription factors on PRC target gene regulation using multi-omic approaches.
- Development of novel therapies for PRC-altered leukemias using large-scale screening approaches.
Such projects will integrate analysis of primary human samples with studies using engineered mouse and cell line models. Technical skills involving tissue culture, mouse models, and standard molecular and cell biology methods are required. Some specific examples of roles include:
- Planning and execution of in vivo experiments in genetically engineered mouse models
- Bone marrow transplantation
- Drug Treatments
- Analysis of peripheral blood and bone marrow stem cells using flow cytometry and cytology
- Application of "omic" technology including DNA/RNA sequencing and epigenetic profiling including ChIP-seq, ATAC-seq, and CUT&TAG
- Isogenic cell line generation and validation using CRISPR
- High-throughput screening methods using CRISPR and drug treatments
Qualifications
The ideal candidate has strong leadership qualities, is collegial, creative, and highly motivated, with a strong record of productivity during graduate training. The Research Scientist will be responsible for working closely in a leadership capacity with a team of post-docs, students, and research technicians to conduct experiments and analyze, present, and publish research findings. The role has the following requirements:
- Ph.D. required in biological sciences or equivalent major
- Strong leadership skills and experience working in teams.
- Strong work ethic, positive attitude, team-centered mentality, and a passion for developing new therapeutic approaches for cancer.
- Outstanding interpersonal skills and excellent verbal and written communication skills.
- Background in molecular and/or cell biology, biochemistry, genomics, cancer biology, or computational biology.
For more information and to apply, please visit:
About Dana-Farber Cancer Institute
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.