Senior Director, Protein Engineering

Senior Director, Protein Engineering
United States - California - Foster City

Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead's therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.

Making an impact on a global scale
Inclusion is one of the company's five core values. That's because we know that we are stronger and more innovative at Gilead when we are informed by a diverse set of backgrounds, experiences and points of view. Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide.

When you join Gilead, you join our mission to change the world by enabling people to live healthier and more fulfilling lives. Come join a mission-driven bio-pharmaceutical organization that values inclusion and diversity, has a strong portfolio of products, and is constantly #CreatingPossible

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At Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer - working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world's biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.

Every member of Gilead's team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we're looking for the next wave of passionate and ambitious people ready to make a direct impact.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.

Job Description

Job Description

The Protein Therapeutics Department in Gilead Research has an exciting opportunity for an inspirational leader experienced in biologics drug engineering and innovation. This position will support all three therapeutic areas (Virology, Oncology, and Inflammation) at Gilead and manage protein engineering efforts supporting protein design to drug candidate activity, manufacturability and format optimization. The ideal candidate will have a proven track record as evidenced by peer-reviewed publications and issued patents. Leadership experience in overseeing biologics projects from protein design to lead optimization and demonstrated ability to develop high-performing teams in an industry setting are crucial attributes of a successful candidate. Gilead Sciences Inc. is a highly matrixed organization. Effective collaboration across multiple function groups is an important attribute of this role.

Responsibilities
Lead protein engineering team to help discover and engineer innovative protein therapeutics including antibodies, multi specifics, and immunocytokines to address unmet medical needs through differentiated mechanisms of actionDevelop compelling team vision and strategies for sustained innovation, technology platform initiatives, and operational excellenceEstablish effective protein engineering workflows at scale by leveraging sequence and structure informatics as well as computational protein designDevelop AI/ML enabled de novo antibody drug design and optimization through design and test reiterationBuild world-class organizational capacity and capabilities to increase cadence and shorten biologics design, build, and test cycle timeCollaborate across functions to enable robust and structured data capture, data analytics, and innovative data sciences to generate novel ideas and insightsCommunicate transparently and timely to key stakeholders to build strong partnership and collaboration experiencesMust be driven by science, detail-oriented, and focused on scale, speed, and quality

Experience
Ph.D. or equivalent in molecular & cell biology, biochemistry, structure biology, or related bioscience field with 12+ years of post-graduate industry experienceState-of-the-art expertise in designing and building innovative protein therapeutics having the intended mechanisms of action and meeting the target product profileSkilled practitioner in protein structure-based design and engineering, proficient in utilizing protein sequence and structure-based bioinformatics software tools.Hands-on experience in protein format design, structural biology, multispecifics, immunocytokines, and Fc engineeringWorking knowledge in biologics expression, purification, functional screening assays, and developability assessmentsFamiliarity with technical reports and IB preparation for IND filingCandidates with project leadership experience with a deep understanding of biologics drug discovery and development processes are highly preferred and will be prioritized

The salary range for this position is: $255, $330, Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

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* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

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