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Postdoctoral Fellow

4 months ago

New York, New York, United States Hospital for Special Surgery Full time

This project will be mainly supported by a newly funded NIH R01 with Dr. Matthew Greenblatt of Weill Cornell Medicine and Dr. Xu Yang of the Arthroplasty Research Lab at the Hospital for Special Surgery as Co-PIs. We will develop key initial elements of a new approach for the regeneration of amputated limbs, by transducing a specific population of autologous skeletal stem cells to induce a blastema-like state, and then implanting them into the amputation site to initiate regeneration of the missing limb.

The candidate may also participate in other projects to invest the cellular and molecular mechanism of the implant osseointegration, including an on-going project funded by Department of Defense.

A candidate having a recent Ph.D. degree in Developmental Biology, Cell and Molecular Biology, or Neuroscience will be desirable. Writing skill and expertise in mouse genetics, light and confocal microscopy, and gold-stand techniques of cell and molecular biology are required. The candidate is expected to have one or more high quality first author publications on cell biology or mouse models of disease or both. The candidate should be highly motivated and productive and interested in a career in research. Expertise in mouse models for wound healing and/or in working with skeletal stem/progenitor lineage cells would be a plus.

Minimum Job Requirements

  • Education/Training: PhD or medical degree
  • Experience: 2+ years of experience in basic science research

Major duties and responsibilities

  • Design and execute experimental procedures/protocols in research involving cell and molecular biology techniques, tissue culture, histology and immunological assay, polarizing and fluorescence microscopy, and animal model system including mouse breeding and genotyping.
  • Collect and analyze data and report to the Principal Investigator on a timely manner.
  • Maintain accurate and detailed records and databases of all laboratory work and experiments.
  • Apply standard scientific protocols to experiments, research and improve current methods, and develop, set-up, and verify new procedures in the laboratory.
  • Standardize and establish new published procedures; evaluate innovative techniques. Develop new assays and new protocols for research. Maintain optimal protocol and assay accuracy by conducting regular quality and reproducibility checks. Timely compile, present and discuss relevant insights about experimental results with Principal Investigator.
  • Maintain and monitor proper use of laboratory equipment. Troubleshoot and correct erroneous results or problems with laboratory equipment.
  • Draft, write, and edit scientific papers, journal articles, abstracts and progress reports related to the work.
  • Maintain an integral role in the laboratory's meetings, departmental seminars, presentations, and publications.
  • Organize and record research material inventory, and place order for research reagent in a timely manner.