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Research specialist, Cell Based Assays

3 months ago

Cambridge, Massachusetts, United States Proclinical Full time

Research Specialist, Cell Based Assays - Contract - Cambridge, Massachusetts

Proclinical is seeking a dedicated and innovative Research Specialist on a temporary contract based in Cambridge, Massachusetts.

Primary Responsibilities:

This role offers the chance to contribute to a growing portfolio of targeted therapies in a dynamic and fast-paced research environment. The ideal candidate will have experience in exploring cellular and molecular mechanisms, particularly in relation to kinase target pathway modulation, off-target liabilities, and resistance.

Skills & Requirements:

MS/BS in oncology, cellular biology, molecular biology, or related discipline.Experience in developing and optimizing cell-based assays in multiple platforms (e.g., CTG, HTRF, AlphaLISA, FC, Jess-WB, NanoBret, Nanostring).Familiarity with different molecular and cellular biology techniques (such as Western Blot).Experience with genome editing (CRISPR or si/shRNA) for engineering cell line models is a plus.Familiarity with tumor models and establishing PK/PD/efficacy relationships and delivering PD readouts by western blots for in vivo tumor models.Experience with standard software analytical tools, xlsx, Prism, or other synergy software.Strong oral and written communication skills, as well as excellent documentation and organizational skills.A team player, who listens effectively, invites response and discussion.Commitment to Core Values: Patients First, Thoughtfulness, Urgency, Trust, Optimism.The Research Specialist's responsibilities will be:Independently develop, optimize, and troubleshoot cellular screening assays.Generate, process, interpret, and present data in cross-functional team meetings.Utilize cell and molecular biology techniques, including gene targeting approaches and small molecule inhibition, to dissect mechanism of action.Independently design, execute and document experiments to evaluate target dependency, off-target liabilities, phenotypic responses and identifying resistance mechanisms.Regularly share and present data with team members. If you are having difficulty in applying or if you have any questions, please contact Mike Raletz at (+1) or .

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

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