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Scientist II, Nanoparticle Formulation

3 months ago

Durham, North Carolina, United States Life Edit Therapeutics Full time

The Role:

Life Edit seeks a nonviral LNP analytical development scientist with relevant experience in academia/industry. The selected candidate will support the lipid nanoparticle (LNP) formulation by characterizing formulations (LNP loaded with Life Edit's novel RNA-guided nucleases (RGNs)/RNPs) as they move from research to preclinical evaluation and eventual clinical advancement. The candidate should possess strong organizational and communication skills and the desire to be part of a highly collaborative and cross-functional team.

Here's What You'll Do:

As part of the nonviral delivery formulation team, you will design, develop, and optimize Life Edit's RNA/RNP nanoparticle characterization and stability assays using state-of-the-art methods.
Characterize the RNA/RNP encapsulated LNPs for their size, zeta potential, morphology, encapsulation efficiency, integrity, and stability using relevant assays (DLS, TEM, Ribogreen, CE, AGE, PAGE, UV-VIS, HPLC, etc.).
Work closely with RNA production, LNP/RNP formulation, and in vitro and in vivo team members.
Ensure adequate rigorous laboratory practices and documentation in a regulatory-ready research manner
Evaluate, interpret, and compile LNP characterization data into study reports for potential regulatory filings
Critically summarize and present data internally to interdisciplinary teams as well as externally.
Write study specific procedures for analytical methods, protocols, and reports and provide training on processes and equipment.

Requirements:
PhD in biological sciences, chemistry, material science, bioengineering, chemical engineering, or related sciences with at least a year of relevant experience or MS with at least 8+ years of relevant experience.
Must have hands on experience in RNA nanoparticle formulation, purification, and characterization assays in academia or direct experience in a biotechnology company.
Must have knowledge and experience in nanoparticle bioanalytical skills such as nanoparticle characterization and RNA/RNP quantitation assays (DLS, TEM, CE, PAGE, AGE, UV-Vis, and HPLC).
Experience working with CRISPR or base editing systems, and RNPs preferred
Demonstrates effective decision-making to steward and prioritize activities to support bench to bedside development programs
Produce formal reports for internal use and regulatory filings
Good verbal and written communication skills

We're committed to finding the best ways to support our teams so they can do their best work. We take care of our employees, right from the start.
Health & Wellness
Medical, vision, and dental insurance covered at 90%
Low deductible, no co-insurance and no copays for mental health visits (for in-network care)
Annual fitness reimbursement
Employer paid for access to wellness apps and programs like Task Human

Financial
Competitive compensation
401(k) retirement plans with a 4% employer match and no vesting period
Employer-paid life insurance and short- and long-term disability insurance
Employer-sponsored flexible spending accounts (FSA) and dependent care account (DCA)
Access to a 1-on-1 financial advisor
Commuter reimbursement benefit
Monthly cell phone stipend

Time Off & Flexibility
Unlimited paid time off, including vacation, sick leave, family leave, personal days, and bereavement
18 paid company holidays, plus an end-of-year holiday shut down
12 weeks of parental leave
Federal Family and Medical Leave Act (FMLA) and Massachusetts Paid Family and Medical Leave (PFML), administered by Unum

Development Journey
Insights Discovery training for every employee to make the most of workplace relationships
Ongoing professional development, including manager training
Access to LinkedIn Leaning, a self-guided online education platform

Why join Life Edit and the ElevateBio ecosystem?

Life Edit Therapeutics is an integrated subsidiary of ElevateBio, a technology-driven cell and gene therapy company that is accelerating access to the cutting-edge technologies and expertise that can change the future of medicine. Our integrated model combines multiple R&D technology platforms – including Life Edit gene editing – and cGMP manufacturing to power the discovery and development of advanced therapeutics. Our ecosystem is designed to enhance speed, delivery, and probability of success to change patient lives.

Life Edit is an integral part of ElevateBio's ecosystem of platform technologies and is pioneering focused next-generation gene editing technologies and therapeutics. Located in Durham, NC, members of Life Edit work closely with the ElevateBio Research and Development and BaseCamp manufacturing teams in Waltham, MA. Life Edit is advancing therapeutic programs in collaboration with industry partners while building its own internal pipeline of gene editing therapies. We are looking for a unique individual who can continue to lead the cultural development of Life Edit and build on its momentum as an integral part of the ElevateBio ecosystem.

Our Mission:
To power the creation of life-transforming cell and gene therapies, at a speed the world deserves.

Our Vision:
We seek to be the world's most indispensable cell and gene therapy technology company, redefining how companies operate, how products are created and how disease is treated.

ElevateBio is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. ElevateBio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.