NGS Scientist
3 weeks ago
Next-Generation Sequencing (NGS) Scientist
5 Months
Cambridge, MA
Job Responsibilities
- Establish workflows utilizing next-generation sequencing technologies to advance antibody discovery efforts from in vitro (yeast and phage), in vivo (single/bulk B cells) or de novo (AI based) platforms with the goal to more deeply interrogate repertoires, expand our knowledge of functional and sequence diversity and accelerate lead discovery.
- Working with computational scientists, establish data analysis pipelines for NGS data.
- Investigate use of NGS in other areas in Global Biologics to accelerate workflows and to enhance pipeline support and accelerate programs to IND.
- Develop and optimize NGS protocols for library generation, sequencing using Illumina MiSeq/NextSeq platforms, and library QC and analysis.
- Establish workflows using NGS in other areas in Global Biologics including cell line generation, plasmid preparation and CAR-T design characterization.
- Generate high quality NGS library (e.g. RNASeq, CITE-Seq) by rigorous optimization and QC process.
- Ability to perform DNA library fragment purification using Blue Pippin and analyze the size using Tape Station 4200.
- Library quantification using qubit and qPCR.
- Continuously improve NGS workflows with integration of automation and informatics.
- Deeply understand and troubleshoot NGS experiments to ensure assay robustness and generation of high-quality data.
- Meet established timelines, maintain accurate records of work.
Education & Qualifications
- Education: BS, MS, or PhD in relevant scientific field
- Experience: If BS, then 11+ years. If MS, then 9+ years. If PhD, then 2-3 years of previous work experience.
- Minimum 3 years of industry experience of hands-on NGS library generation and operating Illumina sequencing platform is required
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