Senior Research Associate

3 weeks ago


Alameda, United States Planet Pharma Full time

Key Responsibilities

  • Formulate and characterize lipid nanoparticle (LNPs) formulations both at small and intermediate scales.
  • Follow SOPs and perform in-process and release analysis of manufacturing operations. Perform set-up and cleanup of equipment and manufacturing space.
  • Assist team to generate LNP formulations for in-house and R&D requirements.
  • Perform analysis of formulations using; UPLC-UV, UPLC-CAD, LC-MS, CGE, DLS, plate-based assays, gels, pH, osmolality, and endotoxin.
  • Data analysis using statistical software’s such as GraphPad PRISM, JMP etc.,
  • Effectively collaborate within various groups and map out future needs and manage procurement of materials.
  • Maintain detailed records of experimental protocols and data in electronic laboratory notebook.
  • Additional duties and responsibilities as required will be assigned based on the needs of the team.

Required skills and background:

  • BS with 5+ years of experience, or MS/PhD with 3+ year of experience in an industry setting. Degree in Chemistry, Biochemistry, Chemical Engineering, Bioengineering, Pharmaceutical Sciences, or related discipline.
  • Experience with downstream processing, such as dialysis, Tangential Flow Filtration (TFF), ultra-filtration and sterile filtration techniques.
  • Experience with drug delivery and RNA are an asset.
  • Excellent collaborative, communication skills and a good team player.

Preferred Skills:

  • Familiarity with CRISPR technologies and therapeutic approaches
  • Knowledge of lipid nanoparticles, analytical characterization of lipids and nucleic acid payloads
  • Ability to run methods and characterization techniques such as Particle size analysis, RNA content analysis, Osmometer, Agarose-Gel, Western Blot, UV-Vis Spectroscopy, UPLC-CAD, UPLC-UV, fragment analyzer, ELISA, 96 well plate-based assays.
  • Knowledge and experience using GraphPad, JMP are preferred.



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