Senior Research Associate
3 weeks ago
Key Responsibilities
- Formulate and characterize lipid nanoparticle (LNPs) formulations both at small and intermediate scales.
- Follow SOPs and perform in-process and release analysis of manufacturing operations. Perform set-up and cleanup of equipment and manufacturing space.
- Assist team to generate LNP formulations for in-house and R&D requirements.
- Perform analysis of formulations using; UPLC-UV, UPLC-CAD, LC-MS, CGE, DLS, plate-based assays, gels, pH, osmolality, and endotoxin.
- Data analysis using statistical software’s such as GraphPad PRISM, JMP etc.,
- Effectively collaborate within various groups and map out future needs and manage procurement of materials.
- Maintain detailed records of experimental protocols and data in electronic laboratory notebook.
- Additional duties and responsibilities as required will be assigned based on the needs of the team.
Required skills and background:
- BS with 5+ years of experience, or MS/PhD with 3+ year of experience in an industry setting. Degree in Chemistry, Biochemistry, Chemical Engineering, Bioengineering, Pharmaceutical Sciences, or related discipline.
- Experience with downstream processing, such as dialysis, Tangential Flow Filtration (TFF), ultra-filtration and sterile filtration techniques.
- Experience with drug delivery and RNA are an asset.
- Excellent collaborative, communication skills and a good team player.
Preferred Skills:
- Familiarity with CRISPR technologies and therapeutic approaches
- Knowledge of lipid nanoparticles, analytical characterization of lipids and nucleic acid payloads
- Ability to run methods and characterization techniques such as Particle size analysis, RNA content analysis, Osmometer, Agarose-Gel, Western Blot, UV-Vis Spectroscopy, UPLC-CAD, UPLC-UV, fragment analyzer, ELISA, 96 well plate-based assays.
- Knowledge and experience using GraphPad, JMP are preferred.
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