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Sr. Research Associate

2 months ago

Alameda, United States Planet Pharma Full time

614191


Our client, a leading Medical Biotechnology company in Alameda, CA , is looking for a Sr. Research Associate to to develop formulations for its CRISPR by Design™ platform. The ideal candidate should have a good understanding of lipid nanoparticle formulations by various mixing and downstream processing techniques.


Skills:

  • BS with 5+ years of experience, or MS/PhD with 3+ year of experience in an industry setting. Degree in Chemistry, Biochemistry, Chemical Engineering, Bioengineering, Pharmaceutical Sciences, or related discipline.
  • 3-5 years of real industry experience, AAV, Viral Vector, MRNA, solid lab analytical skills
  • Experience with downstream processing, such as dialysis, Tangential Flow Filtration (TFF), ultra-filtration and sterile filtration techniques.
  • Experience with drug delivery and RNA are an asset.
  • Familiarity with CRISPR technologies and therapeutic approaches



Responsibilities:

  • Formulate and characterize lipid nanoparticle (LNPs) formulations both at small and intermediate scales.
  • Follow SOPs and perform in-process and release analysis of manufacturing operations. Perform set-up and cleanup of equipment and manufacturing space.
  • Assist team to generate LNP formulations for in-house and R&D requirements.
  • Perform analysis of formulations using; UPLC-UV, UPLC-CAD, LC-MS, CGE, DLS, plate-based assays, gels, pH, osmolality, and endotoxin.
  • Data analysis using statistical software’s such as GraphPad PRISM, JMP etc.,
  • Effectively collaborate within various groups and map out future needs and manage procurement of materials.
  • Maintain detailed records of experimental protocols and data in electronic laboratory notebook.
  • Additional duties and responsibilities as required will be assigned based on the needs of the team.




***Compensation within this range will be commensurate with level of experience***