Sr. Scientist, Immunology
1 month ago
Position Overview
We are looking for a Senior or Principal Scientist to lead our Immunology and Immunoprofiling team. This team develops, validates, implements, and continuously improves cutting-edge analytical platforms to evaluate a patient’s immune status, including multi-parameter flow cytometry, and blood-based next generation DNA and RNA sequencing. This candidate will manage the immunology test portfolio, including all cell-based cytometry and NGS assays ensuring the highest standards of quality, efficiency, and innovation. This position will require a deep understanding of existing and emerging immunoprofiling technologies. This candidate will need to possess exceptional operational management skills, self-motivation to drive continuous improvement in a dynamic, fast-paced environment, and serve as a critical immunology product development driver. The candidate will supervise all blood-based assays used for clinical trial support, academic collaborations, and fee-for-service projects.
Key Responsibilities:
Flow Cytometry Assay Development & Quality Control
- Assist in the development, optimization, and standardization of flow cytometry assays for the analysis of immune cell populations from patient blood and PBMCs.
- Uphold stringent quality control and quality assurance protocols to ensure consistency and reproducibility in flow cytometry data.
- Evaluate and monitor performance metrics to maintain the highest quality of data, ensuring reliable and actionable insights for immunological studies.
- Troubleshoot and resolve technical issues related to flow cytometry instrumentation and protocols to minimize operational downtime and enhance lab efficiency.
Technology and Innovation in Immunology, Immuno-Oncology, and Flow Cytometry
- Stay current with advancements in immunology, immuno-oncology, flow cytometry, and cell-focused technologies.
- Collaborate with R&D leadership to assess, implement, and validate new methodologies to maintain a leading edge in immunological research and clinical trial support.
- Drive continuous improvement and analytical validation of flow cytometry platforms and methods to ensure top-tier performance in clinical and research settings.
Cross-Functional Collaboration
- Collaborate with internal teams, including clinical operations, bioinformatics, and other R&D platforms, to support the integration and deployment of flow cytometry assays in commercial and research projects.
- Work closely with external partners, vendors, and regulatory bodies as necessary to ensure alignment with industry standards and compliance requirements.
- Partner with project management and alliance teams to define project scope, assess feasibility, and ensure alignment with company goals.
Leadership and Strategy
- Execute strategic plans for NGS operations to support the company’s NGS product portfolio, support clinical trials, collaborations, and internal R&D assay development.
- Lead, mentor, and manage a high-performing team of scientists, laboratory technicians, and bioinformaticians.
- Foster a culture of innovation, collaboration, and excellence within the NGS teams in the BG laboratory.
Budget and Resource Management
- Oversee budgeting for immunology assay development and process improvements, ensuring efficient use of resources.
- Manage procurement, inventory, and maintenance of flow cytometry equipment and reagents to support lab operations and control costs.
- Implement cost-saving measures without compromising data integrity or assay quality.
Preferred Skills:
Flow Cytometry Expertise:
- Extensive experience with multi-parameter flow cytometry, including panel design, cell sorting, data analysis, and interpretation of immune cell populations.
Immunology & Immuno-oncology Subject Matter Expertise:
- Deep understanding of cellular phenotypes and immunological signatures, within clinical and translational research contexts.
Assay Development & Tech Transfer:
- Proven experience designing, validating, and transferring flow cytometry and immunology assays from R&D to clinical operations teams.
Team Management & Effective Communication:
- Demonstrated ability to lead interdisciplinary teams and communicate complex data effectively in person or in writing to cross-functional teams and external stakeholders.
Adaptability & Initiative:
- Proactive, self-driven, and highly organized, with the ability to thrive in a fast-paced environment with shifting priorities.
Qualifications:
- Ph.D. in Immunology, Immuno-oncology, or a related field, with 5-10 years of experience in assay development, validation, and/or clinical biomarker discovery.
- Strong background in flow cytometry, with a history of successful application to research or clinical settings.
- Familiarity of bioinformatics tools and data analysis approaches relevant to flow cytometry and next generation sequencing-based analysis.
- Experience in a regulated lab environment (e.g., CLIA, CAP, GCLP) with knowledge of regulatory compliance for clinical trials.
- Strong leadership, communication, and interpersonal skills, with a track record of mentoring and developing scientific talent.
- Knowledge of supply chain management and cost-effective resource allocation to execute complex projects on time and within budget.
- Experience with regulatory compliance.
About BOSTONGENE:
BostonGene is pioneering the development of AI-driven biomedical software for the analysis of multi-omic data from cancer patients on the individual and cohort level. To support this mission, we have a cutting-edge high-complexity molecular laboratory that generates large volumes of high quality data, and a state-of-the-art dry lab staffed by an unparalleled team of data scientists and bioinformaticians. This service is used by our biopharma partners to provide custom solutions for clinical trials; from biomarker discovery to companion diagnostic development. We provide immediate diagnostic solutions for clinicians, such as our Tumor PortraitTM test to tailor optimal treatment strategies to improve cancer patient outcomes.
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