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Scientific - Research Scientist
3 months ago
Duration: 12 Months Contract
Job Description:
The successful candidate will have knowledge in purification and characterization of bispecific antibodies and will be familiar with state-of-the-art methods to support biotherapeutic discovery efforts. The candidate will have demonstrated success in purification of antibodies and complex molecules, executing challenging multi-step purification, analytical data interpretation, troubleshooting and formulation of final product. Experience in automation of high-throughput purification is a plus. The candidate will show an independent ability to design purification methods, understand biochemical concepts and interpret data to generate and improve design. Candidate should have excellent communication skills and a collaborative style. Candidate will be expected to participate in team meetings and provide expertise to support discovery programs.
Responsibilities:
· Primary responsibility is to perform original research to develop marketable products.
· Special emphasis will be placed on automated antibody and bispecific purification, which will involve working with Client AKTA (Pure/Avant) and Unicorn software. Knowledge of Protein Maker instrument a plus.
· Generate mg to gram quantities of material for in-vivo efficacy studies.
· Develop and optimize high-throughput purification capabilities using Lynx900 and KingFisher Flex System.
· Packing of chromatography columns, operating endotoxin free chromatography, including operating preparative (FPLC) and analytical (HPLC) chromatography systems.
· Analytical characterization including endotoxin measurements, protein quantitation assays, analytical HPLC chromatography (HIC, SEC), capillary electrophoresis (CE-SDS and cIEF), DLS, and mass photometry.
· Buffer preparation, molar concentration quantitation and pH adjustment.
· Storing, inventorying, and ordering department supplies.
· Participates on cross-functional teams by performing assigned experiments and offering technical advice at team meetings; shares technical expertise with other colleagues; trains or provides guidance to other personnel, if needed.
· Maintain a neat and clean work environment.
· Manage your workload with minimal supervision.
· Collaborate and communicate with cross-functional teams.
Experience:
· Bachelor's Degree 5+ years of academic / industry experience Or Master's Degree 3+ years of academic / industry experience Or PhD No experience required
Skills:
· Purification and characterization of bispecific antibodies
· Experience with complex modalities
· Automated liquid handling experience a plus
Education:
· Bachelor’s degree.
· Master’s degree
· Ph.D.
About US Tech Solutions:
US Tech Solutions is a global staff augmentation firm providing a wide range of talent on-demand and total workforce solutions. To know more about US Tech Solutions, please visit www.ustechsolutions.com.
US Tech Solutions is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.
Recruiter Details:
Name: Sateesh
Email: podishetty@ustechsolutionsinc.com
Internal Id: 24-14660
