Associate Scientist

3 weeks ago

Cambridge, United States Simcere Zaiming Full time

Simcere Zaiming is expanding its North American presence with a dynamic drug discovery team based in Cambridge, Massachusetts. We are on the lookout for innovative, driven, and autonomous Associate Scientist to enhance our preclinical research division. This role presents an exciting chance to leverage your scientific knowledge in pioneering experiments designed to pinpoint and authenticate novel cancer targets through both in vitro and in vivo humanized models. As an integral part of our laboratory team, your contributions will significantly influence Zaiming’s future pipeline. You’ll have the unique opportunity to engage with various departments within Zaiming, playing a pivotal role in drug development from conceptualization to IND filing.

Responsibilities:

  • Execute cell-based screenings to identify potential targets, employing a range of molecular biology techniques tailored to specific cancer types.
  • Develop and conduct genomic, protein, and cell-based assays for target validation, elucidating discoveries, and their action mechanisms.
  • Carry out sophisticated multi-color flow cytometry to scrutinize immune and cancer cells.
  • Innovate and refine bioanalytical assays, including ELISA, MSD, and Western Blot, for precise quantification of target proteins.
  • Independently design experiments, analyze results, and present findings with minimal oversight.
  • Collaborate with interdisciplinary teams to propel Zaiming’s pipeline forward.
  • Stay abreast of scientific developments within your field of expertise.


Qualifications:

  • Bachelor’s or Master’s degree in Cellular Biology, Immunology, Biochemistry, or a related discipline, accompanied by a minimum of two years’ pertinent experience, preferably from the Industry.
  • Proficiency in molecular biology techniques such as cloning, transformation, transfection, transduction, qPCR, gene editing-CRISPR, RNAi, RNA sequencing, NGS and Western blotting.
  • Expertise in cell culture practices, including handling primary cells (e.g., human T and myeloid cells) and established cell lines.
  • A robust foundation in conducting, analyzing, and troubleshooting cellular assays.
  • Training in various cellular assays like flow cytometry, cell proliferation, and immune functional assays. Familiarity with cell-based imaging (e.g., immunofluorescence microscopy) is valuable.
  • Experience with murine disease models is a plus.
  • Exceptional analytical and problem-solving capabilities.
  • Strong communication skills, adept at multitasking, with a commitment to meticulous record-keeping and organization.
  • A self-starter with a team-centric and results-oriented mindset.

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