Principal Research Scientist I Chemistry
2 months ago
Company Description
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onTwitter,Facebook,Instagram,YouTubeandLinkedIn.
Job Description
AbbVie Process Chemistry is responsible for inventing and characterizing chemical processes and supporting the preparation of drug substances to enable toxicology studies, clinical trials, and drug product development for AbbVies pre-clinical and clinical candidates. We contribute to the development of innovative chemistry solutions and new process technology, resulting in the development of safe, sustainable, and cost-effective manufacturing processes. AbbVie Process Chemistry is seeking a highly motivated Senior Scientist II to Principal Scientist I who can drive the development of antibody-drug conjugate (ADC) drug substances supporting projects from pre-clinical stages through proof of concept.
The candidate will develop processes in lab and lead or participate in project teams to develop conjugation chemistry as well as downstream unit operations (chromatography, UFDF, formulation) ultimately demonstrating via on-scale manufacturing of materials to support our clinical studies. Project teams interactions will include productive collaboration and strong communications with allied functions across analytical, engineering, small molecule drug linker synthesis, regulatory, quality and manufacturing. The candidate must be able to mentor and develop staff with novel experimental approaches to answer difficult scientific questions and may include supervisory responsibilities.
Responsibilities:
The candidate will participate and/or lead project teams associated with process development and characterization for new ADC drug substances.
Develop and characterize antibody drug conjugate (or other modalities) processes in the laboratory and translate them to scalable processes.
Lead, design and execution of process development and control strategies.
Proactively advise and share knowledge and expert opinions with subordinates, peers, and senior management. Mentor staff in troubleshooting strategic and experimental issues.
Author and review key regulatory documents, laboratory data, technical memos and reports.
The position involves multi-disciplinary interactions with organic chemists, analytical chemists, engineers, drug product development, and program management.
The candidate will encourage ideas for continuous improvement activities and initiatives within department.
The candidate will understand and adhere to corporate standards regarding code of conduct, safety and GXP compliance.
Qualifications
Bachelors, Masters, or PhD Degree in Organic Chemistry with typically 14+ (BS), 12+ (MS) or 6+ (PhD) years of experience. Candidates with less experience may be considered for other opportunities.
Experience in antibody-drug conjugate process development.
Proven scientific leadership; strong interpersonal and communication skills for facilitating collaborations and a demonstrated ability to lead cross-functional process development teams.
The successful candidate will have a strong understanding of process development, control strategy development, regulatory starting material strategies, specification setting, QbD principles and tech transfer. An understanding of global regulatory expectations and experience with authoring development reports and regulatory filings is highly desirable.
Key AbbVie Competencies:
Interacts well with diverse groups within function and maintain strong working relationships with internal and external collaborators to enable higher performance.
Learns fast, grasps the "essence" and can change course quickly where indicated.
Raises the bar and is never satisfied with the status quo.
Creates a learning environment, open to suggestions and experimentation for improvement.
Embraces the ideas of others, nurtures innovation and manages innovation to reality.
*Level and compensation will be commensurate with experience.
Additional Information
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:
The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at thetimeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location,andwemay ultimatelypay more or less than the posted range. This range may be modified in thefuture.
We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
This job is eligible to participate in our short-term incentiveprograms.
This job is eligible to participate in our long-term incentiveprograms
Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employee remains in the Company's soleandabsolutediscretion unless and until paid andmay be modified at the Companys sole and absolute discretion, consistent withapplicable law.
AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.
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