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Director of Discovery Toxicology

3 months ago

Salt Lake City, United States Recursion Full time
Your work will change lives. Including your own.


The Impact You’ll Make

Recursion is at the forefront of reimagining drug discovery through the integration of automated cell biology, high-dimensional and diverse data sets, and sophisticated analytics. We are seeking a Discovery Toxicologist who can work with the early project teams to provide scientific expertise and leadership for the safety assessment of Recursion programs from early discovery, through to candidate selection and beyond. You will contribute to the assessment and selection of novel drug targets and the optimisation of novel candidate molecules using innovative molecular, cellular and in vivo technologies to enhance the safety profile of our development candidates. In this role, you will:

Implement innovative experimental or computational strategies using multi-dimensional data to assess and/or provide mechanistic understanding of safety issues. Adapt and apply toxicology screening strategies to predict, assess and mitigate on-target, off-target and other drug-related safety risks in support of the drug discovery portfolio. Provide subject matter expertise on cross-functional project teams within the discovery organization with an opportunity to oversee the preclinical safety strategy in development as projects progress. Act as a key resource for early safety assessment during the discovery phase, providing scientific knowledge and expertise to cross-functional project teams. Collaborate with CROs to ensure best practice for in vitro and/or in vivo safety assessment.

Partner with the project teams to develop optimal strategies to address specific safety issues within project teams. Provide verbal and written summaries for internal discussions. Present summary data to project teams, senior leadership and external partners as needed.

Location:

Making Salt Lake City or Milpitas your home base is ideal, however, we will consider remote work for this position. We ask that remote employees commit to regular on-site visits for routine work and departmental events.

The Team You’ll Join

Reporting to the Vice President of Toxicology you’ll be joining a dynamic toxicology team that works across the portfolio to guide projects through the various stages of discovery and development. This high performing team will work together to continually improve our workflows to drive towards greater efficiency and automation.

The Experience You’ll Need

DVM, Pharm D, Ph.D in toxicology, Pathology, Physiology, Biochemistry or expertise in related biological scientific disciplines with 5+ years’ experience in safety sciences in the Biotech/Pharma industry. Experience in project team membership as a Discovery toxicology representative in a matrix environment. Broad background in novel methods of identifying potential toxicities including computational and in vitro approaches for safety assessment leading to an in-depth knowledge of discovery toxicology. An understanding of in vitro to in vivo translation of potential toxicities and implications for human safety along with experience running and interpreting in vivo safety studies. Highly motivated scientist, who can work independently, with excellent oral/written communication skills. Knowledge of secondary pharmacology assessment and mitigation of identified risks Keen interest in artificial intelligence and its application to drug discovery. Experience with the use of AI-tools to predict toxicology endpoints.

How You’ll be Supported

Integration: high capability leadership team that will help to orient you to biology platform operations Training: access to multimedia training material that will allow you to quickly come up to speed on all that is Recursion. Development: participate in coaching, like BetterUp, for leadership skills and development programs Networking: attend conferences to learn more from colleagues, networks, and more to better your skillset

#LI-CP1

At Recursion, we believe that every employee should be compensated fairly. Based on the skill and level of experience required for this role, the estimated current annual base range for this role is:

Developing: $195,000 Skilled: $216,000 Expert: $239,000

To learn more about our level within levels, clickhere.

You will also be eligible for bonuses and equity compensation + our comprehensive benefits package for United States based candidates. The range displayed on each job posting reflects target ranges for US new hire salaries and is determined by job, level, and market factors.

During the interview selection process, you will connect with a Talent Acquisition Partner who will be your advocate and ally to ensure you receive the appropriate compensation that meets your needs for your skills, experience, and relevant education/training, while also reviewing our very competitive total rewards package.

The Values That We Hope You Share:

We Care: We care about our drug candidates, our Recursionauts, their families, each other, our communities, the patients we aim to serve and their loved ones. We also care about our work. We Learn: Learning from the diverse perspectives of our fellow Recursionauts, and from failure, is an essential part of how we make progress. We Deliver: We are unapologetic that our expectations for delivery are extraordinarily high. There is urgency to our existence: we sprint at maximum engagement, making time and space to recover. Act Boldly with Integrity: No company changes the world or reinvents an industry without being bold. It must be balanced; not by timidity, but by doing the right thing even when no one is looking. We are One Recursion: We operate with a 'company first, team second' mentality. Our success comes from working as one interdisciplinary team.

Recursion spends time and energy connecting every aspect of work to these values. They aren’t static, but regularly discussed and questioned because we make decisions rooted in those values in our day-to-day work. You can read more about our values and how we live them every day here.

More About Recursion

Recursion is a clinical stage TechBio company leading the space by decoding biology to industrialize drug discovery. Enabling its mission is the Recursion OS, a platform built across diverse technologies that continuously expands one of the world’s largest proprietary biological and chemical datasets. Recursion leverages sophisticated machine-learning algorithms to distill from its dataset a collection of trillions of searchable relationships across biology and chemistry unconstrained by human bias. By commanding massive experimental scale — up to millions of wet lab experiments weekly — and massive computational scale — owning and operating one of the most powerful supercomputers in the world, Recursion is uniting technology, biology and chemistry to advance the future of medicine.

Recursion is headquartered inSalt Lake City, where it is a founding member ofBioHive, the Utah life sciences industry collective. Recursion also has offices in London, Toronto, Montreal and the San Francisco Bay Area. Learn more atwww.Recursion.com, or connect onX(formerly Twitter) andLinkedIn. Recursion is an Equal Opportunity Employer that values diversity and inclusion. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, veteran status, or any other characteristic protected under applicable federal, state, local, or provincial human rights legislation. Recursion welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.

Recruitment & Staffing Agencies: Recursion Pharmaceuticals and its affiliate companies do not accept resumes from any source other than candidates. The submission of resumes by recruitment or staffing agencies to Recursion or its employees is strictly prohibited unless contacted directly by Recursion’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Recursion, and Recursion will not owe any referral or other fees. Our team will communicate directly with candidates who are not represented by an agent or intermediary unless otherwise agreed to prior to interviewing for the job.