Current jobs related to Senior Principal Scientist, Global Discovery Chemistry, - Spring House - Johnson & Johnson
-
House Springs, Missouri, United States Johnson & Johnson Full timeAt Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the...
-
Spring House, Pennsylvania, United States Johnson & Johnson Full timeJob SummaryWe are seeking a highly skilled Principal Scientist to join our In Silico Proteins team within the Therapeutics Discovery organization at Johnson & Johnson. As a key member of our team, you will be responsible for developing and implementing computational approaches to accelerate and enhance the discovery of protein-based therapeutics.Key...
-
Senior Scientist
1 month ago
Spring House, United States Pyramid Consulting, Inc Full timeImmediate need for a talented Senior Scientist. This is a 12+months contract opportunity with long-term potential and is located in Spring House, PA (Onsite). Please review the job description below and contact me ASAP if you are interested.Job ID:24-35471 Pay Range: $35 - $38/hour. Employee benefits include, but are not limited to, health insurance...
-
Principal Data Scientist
2 months ago
Spring, United States HP Full timePrincipal Data ScientistDescription - Are you passionate about technology and looking to work in an agile start-up environment that is built on the brand recognition, solution capabilities, and global reach of a world-class technology pioneer? The HP Workforce Employee Experience (HP WEX) team operates in a highly dynamic landscape that delivers a...
-
Bio-Conjugation Scientist
1 month ago
Spring House, United States Net2Source Inc. Full timeBio-Conjugation Scientist12+ Months RoleSpring House, PAThe successful candidate will contribute to a team working on design and characterization of drug candidates based on protein conjugates. They will contribute to the development of therapeutics such as antibody-drug conjugates (ADCs), nucleic acid conjugates (siRNA, antisense, etc.), and peptide/small...
-
Bio-Conjugation Scientist
1 month ago
Spring House, United States Net2Source Inc. Full timeBio-Conjugation Scientist12+ Months RoleSpring House, PAThe successful candidate will contribute to a team working on design and characterization of drug candidates based on protein conjugates. They will contribute to the development of therapeutics such as antibody-drug conjugates (ADCs), nucleic acid conjugates (siRNA, antisense, etc.), and peptide/small...
-
Bio-Conjugation Scientist
1 month ago
Spring House, United States Source One Technical Solutions Full timeSeeking a Bio-Conjugation Scientist for a consulting position at a pharmaceutical client in Spring House, PA. This role is on-site, 40 hours/week.Job Summary:The successful candidate will contribute to a team working on design and characterization of drug candidates based on protein conjugates. They will contribute to the development of therapeutics such as...
-
Bio-Conjugation Scientist
4 weeks ago
Spring House, United States US Tech Solutions Full timeDuration: 12 months contract, Full-TimeEmployment Type: W-2 Job Description:The successful candidate will contribute to a team working on design and characterization of drug candidates based on protein conjugates. They will contribute to the development of therapeutics such as antibody-drug conjugates (ADCs), nucleic acid conjugates (siRNA, antisense, etc.),...
-
Bio-Conjugation Scientist
6 days ago
spring house, United States US Tech Solutions Full timeDuration: 12 months contract, Full-TimeEmployment Type: W-2 Job Description:The successful candidate will contribute to a team working on design and characterization of drug candidates based on protein conjugates. They will contribute to the development of therapeutics such as antibody-drug conjugates (ADCs), nucleic acid conjugates (siRNA, antisense, etc.),...
-
Bio-Conjugation Scientist
1 month ago
Spring House, United States US Tech Solutions Full timeDuration: 12 months contract, Full-TimeEmployment Type: W-2 Job Description:The successful candidate will contribute to a team working on design and characterization of drug candidates based on protein conjugates. They will contribute to the development of therapeutics such as antibody-drug conjugates (ADCs), nucleic acid conjugates (siRNA, antisense, etc.),...
-
Bio-Conjugation Scientist
6 days ago
spring house, United States US Tech Solutions Full timeDuration: 12 months contract, Full-TimeEmployment Type: W-2 Job Description:The successful candidate will contribute to a team working on design and characterization of drug candidates based on protein conjugates. They will contribute to the development of therapeutics such as antibody-drug conjugates (ADCs), nucleic acid conjugates (siRNA, antisense, etc.),...
-
Principal Data Scientist
2 months ago
Silver Spring, Maryland, United States HP Full timePrincipal Data ScientistDescription -Are you passionate about technology and looking to work in an agile start-up environment that is built on the brand recognition, solution capabilities, and global reach of a world-class technology pioneer? The HP Workforce Employee Experience (HP WEX) team operates in a highly dynamic landscape that delivers a...
-
Scientist 2 - Research and Development
1 month ago
Spring House, United States US Tech Solutions Full timeDuration: 16 months contract, Full-TimeEmployment Type: W-2 Job Description:Entry-level contract scientist to support biochemical testing of recombinant biotherapeutic proteins. Methods to be utilized include, but are not limited to, high performance liquid chromatography, gel and capillary electrophoresis, UV spectrophotometry, and capillary isoelectric...
-
Scientist 2 - Research and Development
1 month ago
Spring House, United States US Tech Solutions Full timeDuration: 16 months contract, Full-TimeEmployment Type: W-2 Job Description:Entry-level contract scientist to support biochemical testing of recombinant biotherapeutic proteins. Methods to be utilized include, but are not limited to, high performance liquid chromatography, gel and capillary electrophoresis, UV spectrophotometry, and capillary isoelectric...
-
Protein Conjugation Research Scientist
2 weeks ago
Spring House, Pennsylvania, United States Integrated Resources, Inc ( IRI ) Full timeJob Title: Protein Conjugation Research ScientistCompany: Integrated Resources, Inc (IRI)Job Overview:The ideal candidate will be an integral part of a collaborative team focused on the innovation and evaluation of therapeutic agents utilizing protein conjugates.Key Responsibilities:Engage in the design and analytical assessment of drug candidates,...
-
Development Scientist
2 months ago
Silver Spring, United States Elutia Full timePosition Overview:The Development Scientist at Elutia plays a pivotal role in pioneering and developing biological-based medical devices, specializing in drug/device combination products at the forefront of the industry. This role encompasses overseeing the entire development process, from initial concept through to commercialization. The Development...
-
Data Scientist
3 weeks ago
Spring House, United States Eurofins USA PSS Insourcing Solutions Full timeJob DescriptionJob DescriptionCompany DescriptionEurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on,...
-
Silver Spring, United States International Executive Service Corps Full timeThe Alaka ina Foundation Family of Companies (FOCs) has a potential need for a Social and Behavioral Scientist II/Principal Investigator to support our government customer located in Silver Spring, MD. DESCRIPTION OF RESPONSIBILITIES: Conducts research and development activities in support of behavioral health efforts for the military. Responsible for...
-
Silver Spring, United States Goldbelt, Inc. Full timeOverview Goldbelt Apex, LLC is an Alaska Native 8(a) firm that specializes in medical logistics, equipment modernization, maintenance, business analysis and innovative technologies to accelerate the delivery of health care across the military, federal, and civilian landscapes. Goldbelt Apex, LLC is headquartered in Juneau, Alaska with offices in Herndon,...
-
Principal Data Scientist
2 months ago
Silver Spring, United States eSimplicity Full timeJob DescriptionJob DescriptionDescription:About UseSimplicity is a modern digital services company that delivers innovative federal and commercial IT solutions designed to improve the health and lives of millions of Americans while defending our national interests. Our solutions and services improve healthcare for millions of Americans, protect our borders,...
Senior Principal Scientist, Global Discovery Chemistry,
1 month ago
At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at
The Peptide group within Global Discovery Chemistry group is committed to the delivery of high-quality drug candidates working across all Therapeutic Areas (TAs). This mission requires deep scientific expertise in a number of disciplines including chemistry, cellular and molecular pharmacology, enzymology, and screening technologies coupled with an ability to work collaboratively with internal and external partners. Building on a strong legacy of success, we are currently seeking an outstanding individual to join our team as Scientist, Discovery Chemistry. This position will be based at our drug discovery site in Spring House, PA.
We are seeking an experienced, highly skilled, and motivated chemist with excellent peptide chemistry and medicinal chemistry expertise to shepherd peptide drug discovery programs and advance them toward the clinic. This position will require the candidate to possess and leverage deep knowledge and capabilities to deliver differentiated clinical candidates to the Janssen product development pipeline within our Disease and Pathway Area Stronghold (DAS and PAS) strategy. Using a mix of internal and external resources, the Principal Scientist will partner with key stakeholders in the TAs and other internal groups, represent medicinal chemistry, lead cross-functional project teams, and be co-responsible for building, managing, and delivering high quality clinical molecules.
Responsibilities of the Senior Principal Scientist will include:
• Independently designing and synthesizing drug-like peptide molecules utilizing current medicinal chemistry knowledge, including property-based optimization, and an understanding of ADME, pharmacokinetics and optimal physicochemical properties.
• Drive Medicinal Chemistry, Peptide programs for one or more drug discovery projects, working in concert with partners in molecular and cellular biology, pharmacology, computational chemistry, ADME, structural biology, chemical development, and contract research organizations (CROs)
• Apply and build Peptide capabilities using state-of-the-art design, chemistry, and technology across Therapeutic Discovery
• Excellent communication to develop effective partnerships across J&J and with external partners
• Contribute to portfolio and stage-gate reviews, lead the preparation and presentation of dossiers for clinical candidate nomination and compound advancement
• Serve as a scientific expert in peptide and medicinal chemistry with both internal and external partners and provide recommendations regarding emerging opportunities.
• Analyze synthetic routes to designed compounds, screening data, perform literature reviews, design, propose, and execute medicinal chemistry plans, coordinate chemistry and biology data to support compound progression and patent strategies
• Provide scientific direction and leadership for synthetic and medicinal chemistry activities of internal, external FTEs and contract research organizations (CROs). This role may have direct people management responsibilities.
• Participate in shaping and implementing strategies that support synthetic and medicinal chemistry growth objectives at J&J, including academic relations and talent acquisition
• Ensure optimal interaction/communication and provide updates on project status to leadership
• Maintain a significant level of productivity in the laboratory setting
Qualifications
• PhD in peptide, synthetic organic, or medicinal chemistry or relevant industrial experience (>7 yr)
• A minimum of 5 or more years' additional experience in the biopharmaceutical industry working with Peptides.
• Experience designing peptides using computational modeling tools including (1) peptide conformational restraints to influence secondary structure, (2) constrained macrocycles for affinity or properties, and/or (3) de-peptidization strategies including back-bone modifications and peptidomimetics
• Good understanding of cellular/molecular biology, biochemistry, disease pharmacology, mechanisms of drug metabolism and molecular toxicology,
pharmaco-kinetic and pharmaco-dynamic sciences, and formulations for the in vivo evaluation of drug candidates
• Knowledge of and/or experience with computational chemistry methods and biophysical techniques such as X-ray crystallography and macromolecular NMR
• Strong problem-solving skills for developing creative, innovative solutions, and meeting project objectives
• Demonstrated influence, negotiation, and conflict resolution skills, including the ability to succeed within a matrixed, global environment
Preferred:
• Experience is:
o Permeable and orally bioavailable peptides
o Peptide hit finding approaches
o Intracellular protein-protein interaction targets
o Cell penetrating peptides
o Chemical biology using cyclic peptide scaffolds
• Strong track record of scientific contributions including peer reviewed first-author publications, patent applications, and presentations at major national meetings
• Oral peptide design strategies, including half-life extension approaches and incorporation of unnatural amino acids is preferred
• Demonstrated operational skills for contributing to discovery programs at the level of a senior chemist
• Broad experience and proven accomplishments in one or more Therapeutic Areas