Research Associate II, in vitro Pharmacology

2 months ago

Boston, United States Entrada Therapeutics Full time
The Organization

What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible.

Our Endosomal Escape Vehicle (EEV™)-therapeutics are designed to enable the efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues, resulting in an improved therapeutic index. Through this proprietary, versatile and modular approach, Entrada is advancing a robust development portfolio of RNA-, antibody- and enzyme-based programs for the potential treatment of neuromuscular, ocular, metabolic and immunological diseases, among others.

Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne who are exon 44, 45 and 50 skipping amenable. We have also partnered to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1.

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families. The Perfect Addition to Our Team

You should be versatile, self-motivated, and looking forward to rolling up your sleeves, as you will be involved in all aspects of our pharmacology studies. You have a team player mentality and excellent communication skills that will allow you to collaborate effectively as you work alongside your team as well across-functionally within the organization. The Opportunity

The in vitro Pharmacology contractor will primarily be focused on contributing to the execution of in vitro experiments, directly fulfilling company goals, and validating our modular intracellular delivery platform.

This position offers a long-term contract opportunity with Entrada. The individual will be based on-site 5 days per week in our Seaport office. Responsibilities

Contribute broadly to advancing validated targets into the drug discovery pipeline. Responsible for carrying out in vitro preclinical studies to advance programs including target nomination, analysis, and building scientific rationales for disease selection. Evaluate, validate, and develop disease models to investigate the efficacy of EEV-mediated delivery including in vitro techniques to drive go/no-go decisions. Regularly collaborate across teams and with the Discovery Group to demonstrate mechanistic proof-of-concept and contribute to selecting novel therapeutic modalities that include oligonucleotides, peptides, and antibodies. The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

Humanity - We genuinely care about patients and about one another. Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients. Creativity - We are creative problem solvers. Collaboration - We are more than the sum of our parts. Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

Bachelors with 2 – 4 years or Masters degree with experience performing in vitro cell culture and biochemical assays within academia and/or the pharmaceutical/biotech industry. Experience with in vitro laboratory techniques such as PCR, gel electrophoresis, Western blots, RNA and protein extraction, qPCR, ELISA, mammalian cell (tissue) culture, transfection, and lentiviral related work experience. Experience with cellular readouts such as luminescence, cell viability, fluorescence, ELISA, flow cytometry, high content imaging, etc. is ideal. Be able to solve routine operation and scientific problems requiring deductive reasoning. Good working knowledge of Microsoft suite of Software (Word, Excel, PowerPoint). Excellent verbal and written communication skills Strong communication skills and ability to work effectively across cross functional teams. “Hands-on” mentality in moving projects forward Desire to work in an innovative and collaborative environment pursuing high reward science. The Perks

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, paternity leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law. Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes. Privacy Statement

Entrada Therapeutics, Inc. (the “Entrada,” “we,” “us,” or “our”) respects your privacy and we want you to be familiar with how we collect, use, share, or otherwise process, your Personal Information. Please reference our privacy statement here to understand how and when your data is being used.

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