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Senior Research Associate I/II – In Vivo
1 month ago
Senior Research Associate I/II – In Vivo
Location: Boston, Massachusetts
Monte Rosa Therapeutics is searching for a Sr Research Associate I or II in Immunology/Oncology to provide expertise in developing innovative molecular glue degraders, aiming to deliver a new generation of treatments to patients. This individual will design and execute pivotal proof-of-concept studies in pre-clinical models of inflammation, immunology, and oncology, and assist in the cross-functional development of our research strategy. The role involves interacting with team members to design and execute in vivo/ex vivo pharmacology studies aimed at defining the activity and mechanism of action of compounds. Significant cross-functional collaboration with a talented and dedicated group of scientists including chemists, cell biologists, immunologists, will ensure a diverse exposure to the drug discovery process. This person will work primarily in our Animal Care Facility, with an opportunity to expand their scope at the lab bench.
Principal Duties and Responsibilities:
Perform basic and intermediate veterinary technical tasks in mice independently, including the following:
Administration of selected agents by PO, IP, IV, IM, SC routes.
Blood sampling techniques via multiple routes, including submandibular bleed.
Tumor implantation on flank, followed by tumor volume measurements.
Preparation of compound formulation for in vivo dosing.
Optimize and perform studies to define target biology in mouse models of inflammation and immunity for in vivo, in vitro and ex vivo applications.
Maintain accurate laboratory records/notebooks, procedures, and data summaries.
Generate high-quality data reports and provide suggestions for future work to management and project teams.
Qualifications:
BS/MS in Biology, Pharmacology, Animal Science, or related field with minimum 4 years relevant experience in an industry setting.
AALAS certification at the ALAT level is preferred. Uncertified candidates must obtain ALAT certification within 12 – 18 months or demonstrate substantial progress toward certification. LVT qualification is a plus.
Prior experience necessary in handling compounds for formulation preparation, with a strong emphasis on safety and proficiency in performing necessary calculations.
Strong experience in animal handling is required, including compound administration by multiple routes, harvesting tissue and blood samples, and performing necropsy techniques. Experience with surgical techniques is a plus.
Experience in culturing mammalian cell lines is advantageous.
Experience with pharmacodynamics assays of mouse tissue, including Western Blotting, ELISA/Mesoscale and flow cytometry is a plus.
Interested Candidates may forward CV and Cover Letter letting us know your area of interest please forward to Careers-US@MonterosaTx.com
Or apply online
Monte Rosa Therapeutics (MRT) is a clinical-stage biotechnology company developing highly selective molecular glue degrader (MGD) medicines for patients living with serious diseases in the areas of oncology, autoimmune and inflammatory diseases, and more. MGDs are small molecule protein degraders that have the potential to treat many diseases that other modalities, including other degraders, cannot. Monte Rosa’s QuEEN™ (Quantitative and Engineered Elimination of Neosubstrates) discovery engine combines AI-guided chemistry, diverse chemical libraries, structural biology, and proteomics to identify degradable protein targets and rationally design MGDs with unprecedented selectivity. The QuEEN discovery engine enables access to a wide-ranging and differentiated target space of well-validated biology across multiple therapeutic areas. Monte Rosa has developed the industry’s leading pipeline of MGDs, which spans oncology, autoimmune and inflammatory disease and beyond, and has a strategic collaboration with Roche to discover and develop MGDs against targets in cancer and neurological diseases previously considered impossible to drug.
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Senior Research Associate I/II – In Vivo
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Boston, United States Monte Rosa Therapeutics Full timeSenior Research Associate I/II – In VivoLocation: Boston, Massachusetts Monte Rosa Therapeutics is searching for a Sr Research Associate I or II in Immunology/Oncology to provide expertise in developing innovative molecular glue degraders, aiming to deliver a new generation of treatments to patients. This individual will design and execute pivotal...
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