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Senior Research Associate, Neuromuscular Research
4 months ago
Dyne Therapeutics is a clinical-stage muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue. Dyne has a broad pipeline for serious muscle diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and a preclinical program for facioscapulohumeral muscular dystrophy (FSHD).
Role Summary:
The Senior Research Associate in neuromuscular research helps to develop new therapies for neuromuscular diseases. This role is involved in all aspects of in vitro/in vivo neuromuscular disease biology, evaluating efficacy, pharmacodynamics, pharmacokinetics, and mechanisms of action of our therapeutic molecules. The ideal individual for this position is an innovative and collaborative team player and an ambitious self-starter who enjoys working in a fast-paced team setting.
This is a full-time position based in Waltham, MA without the possibility of being remote.
Primary Responsibilities:
Execute, and analyze in vitro and in vivo studies to profile therapeutic candidates and drive progression of research projects from research to clinical development Contribute technically and intellectually to development of new assays aimed at answering key neuromuscular disease questions Execute assays to drive optimization of the FORCE™ platform Communicate findings to team members and management Contribute to building a positive culture of teamwork and scientific excellence Document research efforts and maintain proper recordsEducation and Skills Requirements:
BS/MS or equivalent in a relevant biological discipline and 1-3 years of hands-on biotech/biopharma or academic experience Extensive experience conducting in vivo studies with small rodents including: Dosing by several routes of administration Tissue collection and processing for downstream assays High degree of proficiency with standard histological protocols such as tissue-fixation, embedding, sectioning, immunofluorescence, and immunohistochemistry Proficiency with molecular biology techniques, including: Cell culture ELISA and other plate-based assays. Western blots Gene expression analysis by qPCR or digital PCR Molecular cloning Hands-on experience developing in vitro cell-based and cell-free assay is highly desirable Familiarity with DNA and RNA sequencing techniques is desirable Ability to communicate ideas and document research effectively and clearly Highly organized and collaborative Experienced in the use of software applications such as Prism, Excel, PowerPoint, and SnapGene (or equivalent)#LI-Onsite
The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.
This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time. The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.
Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.
