Research Associate II

4 weeks ago


Rockville, United States MacroGenics, Inc Full time
  • The Research Associate II/Associate Scientist I will be part of the Targeted Therapeutics Group focused on generating novel antibody-based therapies for the treatment of cancer and autoimmune diseases.
  • Purify, and characterize ADCs using FPLC, HPLC, and mass spectrometry (MS).
  • Tasks will include cell culture, cytotoxicity assay, ELISA and cell binding assays, flow cytometry, western blots, RNA isolation, and in vitro cellular functional assays.
  • Support mass spectrometry (MS)-based analysis of ADC catabolism in cells, plasma and tumors.
  • Direct experience in protein conjugation, protein purification, peptide chemistry, and preferably generation of ADCs. Knowledge of protein analytical methods such as HPLC (HIC, aSEC, ion exchange, reverse phase), LC-MS, SDS-PAGE, UV-vis spectroscopy.
  • Experience with biochemistry techniques to evaluate drug potency and MOA: may include flow cytometry, ELISA, cell-based cytotoxicity assays, western blots, 2D/3D cell culture, internalization assays etc.
  • Direct experience in antibody conjugation, purification and characterization using bioanalytical techniques.
  • Experience with biochemistry techniques to evaluate drug potency and MOA is a plus.

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