Lead, Pipeline Management and Lab Operations

3 weeks ago

New York NY, United States Memorial Sloan Kettering Cancer Center Full time

Our specialized care teams provide personalized, compassionate, expert care to patients of all ages. Informed by basic research done at our Sloan Kettering Institute, scientists across MSK collaborate to conduct innovative translational and clinical research that is driving a revolution in our understanding of cancer as a disease and improving the ability to prevent, diagnose, and treat it. MSK is dedicated to training the next generation of scientists and clinicians, who go on to pursue our mission at MSK and around the globe.
Please review important announcements about vaccination requirements and our upcoming EHR implementation by clicking here .

Your Career Hub profile is submitted to the hiring team as your internal resume. The Head of the RNA Therapeutics Laboratory will lead a laboratory team envisioned as the nexus for R&D activities in the newly established Center for Cancer Vaccines at MSK, a key pillar in MSK's immuno-oncology transformation.
Oversee creation of an independent, end-to-end mRNA vaccine pipeline at MSK, encompassing vaccine platform optimization and GMP manufacturing for clinical use
modifications to optimize the mRNA template, structure, stability, production through techniques, such as in vitro transcription, purification, and encapsulation in lipid nanoparticles
Lead/oversee RNA vaccine quality control, which paired with research and technology development, will develop and optimize analytical assays to evaluate the quality and efficacy of mRNA vaccines
Transfer these assays, when appropriate, to the GMP-Therapeutics Core Facility, and collaboratively support vaccine manufacturing.
Provide oversight and leadership to the technical staff
Set the short-, medium- and long-term scientific directions of the laboratory by evaluating emerging technologies together with the needs of MSK scientists, physicians, and the overall scientific direction of the Center for Cancer Vaccines
Operational responsibilities encompass oversight of advanced methods development, scientific consultation, and liaising with the scientific community to grow a sustainable state-of-the-art operation
Responsible for the financial and human resource management (e.g., hiring, training, mentoring, and staff career development)
Working hand in hand with the MSK GMP -Therapeutics Core Facility , the candidate is expected to align the lab's mission with the institutional strategic goals and will report to the Cancer Vaccine Center director and a faculty oversight committee.
5+ years of experience in the academic or commercial sector.
Expertise in mRNA-LNP platforms, cGMP process flow, and analytical panel development; experience with IND applications highly desired
Experience managing laboratory staff and overseeing day-to-day laboratory operations essential
A quick learner and strong problem-solver who sees "the forest and the trees" and can quickly identify anomalies in data and uncover their source
Adept at multitasking, planning, prioritizing, and re-prioritizing work to meet goals and commitments with minimal supervision in a dynamic environment
A highly motivated person capable of building strong relationships within the lab and with internal and external collaborators
Someone with a strong background of mentorship who is interested in the success of others and willing to evaluate performance and provide constructive feedback as a manager
A creative thinker and strategic planner who can think outside the box
Schedule: Monday - Friday, 9 am - 5 pm
Closing: MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision.
Federal law requires employers to provide reasonable accommodation to qualified individuals with disabilities. Examples of reasonable accommodation include making a change to the application process or work procedures, providing documents in an alternate format, using a sign language interpreter, or using specialized equipment.

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