Scientist I Medical Chemistry

3 weeks ago

San Diego CA, United States Neurocrine Biosciences, Inc. Full time

Neurocrine Biosciences is a neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. *Responsible for devising the medicinal chemistry strategy on projects. May lead or co-lead multi-disciplinary project teams to advance discovery programs to key milestones. Provides expertise in medicinal chemistry principles, complex small molecule synthesis, purification, and data analysis. Supervises and mentors both internal direct reports and external CROs towards hypothesis driven chemistry strategies. Monitors and evaluates completion of tasks and projects. Contributes to development of policies and department strategies.
Leads projects and initiatives in the rapid optimization of lead molecules utilizing modern technology available to medicinal chemists such as automated synthesis and purification

~ Distills complicated, multidimensional data to clear hypotheses and new experimental directions

~ Researches external intellectual property relevant to project(s) and areas of pursuit

~ Responsible for designing, planning, and conducting synthesis of analog libraries as well communicates results to the project or program team

~ Plans and manages projects. Represents Medicinal Chemistry on cross-functional teams. Maintains accountability for deliverables and progress for projects

~ Independently designs, plans and executes activities towards the goals of one or more Medicinal Chemistry projects to support lead generation through pre-clinical activities

~ Supervises laboratory work and/or lab personnel and ensures safe laboratory practices

~ Creates and implements novel ideas in Medicinal Chemistry

~ Provides effective supervision of laboratory personnel and guidance for their professional development

~ BS/BA in Chemistry and 12+ years of experience in chemistry, parallel synthesis, lab automation, and purification in the optimization of lead compounds OR
MS/MA in Chemistry preferred and 10+ years of experience OR
PharmD or PhD in Chemistry preferred and 4+ years of relevant experience; may include postdoc experience
Advanced knowledge of any or all of the following: complex organic synthesis, parallel synthesis, data analysis, lab automation, and purification in the optimization of lead compounds
Thorough understanding of medicinal chemistry and a well-developed understanding of current literature
Excellent laboratory and productivity skills
Assimilates data and research findings outside of Neurocrine for application to new scientific projects
Maintains broad knowledge of scientific principles and theories and possesses intellectual mastery of one or more scientific areas
Advanced knowledge and demonstrated ability working with / recommending a variety of laboratory equipment/tools
Excellent computer skills
Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency
Excellent project management skills

#Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.
We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. In addition, this position offers an annual bonus with a target of 30% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.
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