Scientist I, Radiochemistry

4 weeks ago

San Diego, United States RayzeBio Full time

Job Title: Scientist I, Radiochemistry

Location: San Diego


Background

RayzeBio is a dynamic biotechnology company headquartered in San Diego, CA. Launched in late 2020 and recently acquired by Bristol Myers Squibb (BMS) as a wholly owned subsidiary, the company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio will operate as a standalone entity within the BMS organization, maintaining its biotech culture with the opportunity to leverage the best-in-class oncology capabilities of BMS. RayzeBio is developing innovative drugs against targets of solid tumors. The lead asset, RYZ101, is in Phase 3 testing for patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs), as well as earlier stage testing for patients with small cell lung cancer (SCLC) and breast cancer. Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals.


Summary

The Scientist will be responsible for conducting research, experiments, and analysis in the field of radiochemistry. This role involves radiolabeling of diagnostic and therapeutic radioisotopes of peptides, small molecules, and/or antibodies as well as quality testing for in vitro and in vivo work. The Scientist will work in laboratory settings, collaborating with interdisciplinary teams to advance scientific knowledge and contribute to the advancement of all RayzeBio’s internal programs.


Job Responsibilities

Essential duties and responsibilities include the following. Other duties may be assigned.

• Develop and optimize experimental procedures ad methods, as well as conduct experiments to radiolabel peptides, small molecules and/or antibodies using various isotopes including but not limited to: Lu-177, Ac-225, Cu-64, Ga68 and Zr89

• Develop and execute methods for the characterization of radiolabeled compounds, using techniques such as radio-HPLC and radio-TLC chromatography to analyze purity and stability

• Develop novel methods and conduct in vitro assays (e.g. plasma stability and metabolite analysis) with radiolabeled compounds

• Prepare compounds for cell-binding assays and in vivo biodistribution and dosimetry studies

• Evaluate and present all radiolabeling methods and analytical results in functional meetings to provide input to progress internal programs

• Develop, interpret, and maintain appropriate documentation using GxP guidelines, including radiolabeling protocols, reports and data analyses

• Maintain a clean and safe working environment



Education and Experience

  • A Ph.D or Master’s degree in radiochemistry, chemistry, nuclear chemistry, or related field
  • A minimum of 5 years of experience in radiochemistry, radiopharmaceutical, and/or CMC development field
  • Demonstrated experience in radiochemistry techniques and quality control instruments including but not limited to radioHPLC, TLC, gamma counter, gamma spectroscopy
  • Proper radiation safety practices during radiosynthesis, radioanalytical chemistry operations, and when physically within the lab areas at all times
  • Ability to work both collaboratively and independently in a fast-paced and cross-functional environment


Skills and Qualifications

  • Hands on experience working with radioactive materials and radiation instrumentation in a radiochemistry laboratory setting.
  • Highly motivated and organized professional with the ability to work both with a team and independently
  • Multi-disciplined scientist with ability to troubleshoot
  • Excellent professional ethics, integrity, and ability to maintain confidential information

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