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Research Associate/Senior Research Associate, Cell Based Discovery Platform
3 months ago
Our mission is to develop transformational genetic medicines utilizing novel delivery technologies, with an emphasis on diseases with significant unmet medical need. Our team is advancing multiple innovative approaches to deliver a variety of therapeutic payloads, focusing initially on gene editing in therapeutically relevant cells and tissues. Our world class scientific founders include Professor David Liu (HHMI, Broad and Harvard) and Professor Keith Joung (Arena BioWorks, formerly MGH), and we are funded with a significant capital investment by leading life science venture capital firms including Newpath Partners, Atlas Venture, F-Prime Capital, and 5AM Ventures. We believe that our technology has the potential to positively impact patients suffering from severe genetic diseases, and we are committed to building an excellent, science-driven and diverse team that is passionate about making a difference. Nvelop Therapeutics is based in Cambridge, MA.
Position Overview
We are seeking an experienced, motivated, and growth-oriented Research Associate/ Sr. Research Associate to join our Cell Biology team. The successful candidate will contribute to our efforts to build a high-throughput Cell Based Discovery Platform incorporating relevant cell lines and primary cell panels to enable broad exploration of particle design space for improvements in potency and tropism. Working closely with their supervisor, the candidate will contribute to the design of experiments, execute and document experimental work, perform laboratory support work as needed, and contribute to data analysis and communication of experimental results.
The ideal candidate will have hands-on experience with relevant cell models including primary cells, molecular and cell biology methods, and the capability and desire to learn and apply new experimental methodologies. Drive to execute, experimental rigor and scientific curiosity are key We are a small and growing company, so the ability to work in a fast-paced environment and adapt to evolving priorities is a must. Job Responsibilities
- Contribute to the development of cell line and primary cell panels to characterize potency and tropism of novel delivery technologies
- Contribute to development and maintenance of a Cell Bank for the Research organization. Write SOPs and generate electronic inventory of different cells.
- Work on projects involving bioassay development, transfections/transduction assays and, mechanism of action studies utilizing novel gene editing delivery technologies
- Apply methods in cell biology, cell culture, molecular biology, and biochemistry to advance scientific projects
- Working with supervisor, selecting the most suitable methodology, and contributing to the design of experiments, execution, and data analysis.
- Independently set up and prepare routine experiments as directed. Execute protocols of non-routine experiments with supervision as needed
- Perform calculations, record and document data, analyze data using scientific and statistical methods, and communicate results
- Lab administrative responsibilities including ordering and tracking of laboratory supplies, preparation of lab reagents, chemicals, instruments and equipment for use
- Bachelor’s degree in biological science or a related field with 0-5 years of post-graduation industry experience
- Experience with mammalian cell culture, PCR, and related cell/molecular biology methods including microscopy and flow cytometry
- Familiarity with stable cell line development and experience working with viral vectors/nanoparticles preferred
- Experience with hepatocyte isolation from different species is a plus.
- Strong problem-solving, organization, and communication skills
- Ability to work independently as well as part of a team
- Ability to adapt to a fast-paced environment
Full time in-person work is necessary for our laboratory-based positions. We work in facilities that require that all individuals working on-site are vaccinated for COVID-19. Position Title and Salary will be commensurate with Experience
We recognize the value of diversity in our workforce and are committed to building a welcoming and supportive working environment. We consider all qualified applicants without regard to race, religion, color, gender, age, national origin, sexual orientation, gender identity, partnership status, protected veteran status, disability, or any other status protected by federal, state, or local law. Individuals who hold legal work authorization applicable to employment in the United States will be considered without regard to citizenship/alienage.
We are not accepting unsolicited resumes from employment agencies for any employment opportunities at this time.
