Principal Institute Research Scientist Medicinal Chemistry

4 months ago

Houston, United States MD Anderson Cancer Center Full time
This Institute Principal Research Scientist (Medicinal Chemistry) will lead cross-functional research to discover lead molecules for progression into novel oncology therapeutic agents that benefit patients. They will be a highly creative synthetic chemist with a strong desire to succeed at the highest level. They will be responsible for the design, optimization and synthetic execution of small molecule targets from hits to leads, as well as leadership/management of junior scientists and project teams towards those goals. By liaising with other members of the cross-functional project team, this individual will play a key role in the identification and optimization of the next generation of cancer therapeutics.

JOB SPECIFIC COMPETENCIES

Know your business
* Apply and develop cutting-edge medicinal chemistry tools and methodologies to enable advancement of Institute projects through leadership and experimental activities.
* Analyze data generated by various studies and leverage results for the design of future target molecules.
* Collaborate with data scientists to triage high-throughput screening results and identify promising hits using cheminformatics techniques (, physicochemical property prediction)
* Apply chemistry-based data analytics software to identify early-SAR trends, track series progressibility, and design/optimize focused libraries
* Apply state of the art chemistry skills to optimize molecules from hit-finding exercises to enable progression of programs into lead optimization. Leverage latest synthetic approaches, parallel medicinal chemistry and purification techniques.
* Adapt to new technologies and find solutions to related program studies.
* Lead in the design and synthesis of small molecule modulators of protein targets through lab-based activities.
* Lead in the hypothesis generation and design of new target molecules with improved overall profile.
* Work closely with medicinal chemists, computational chemists and other project team members in the design and optimization of compounds with improved potency, selectivity, and functional activity on their protein target, together with improved ADME properties.
* Trouble shoot synthetic issues with their synthetic targets, as well as those of other project team members.
* Manage patent filings in order to secure the intellectual property rights for novel small molecules.
* Employ safe lab practices.
* Maintain research records and laboratory notes.

Know the business of your department/institute
* Interact across functions.
* Employ safe lab practices.
* Maintain research records and laboratory notes.
* Self-adaptability: Work in situations involving uncertainty, shifting priorities, and rapid change; deal constructively with mistakes and setbacks; demonstrate flexibility.

Change Agent
* Adapt to new technologies and find solutions to related program studies.

Other duties as assigned

COMPETENCIES

Analytical Thinking - Gather relevant information systematically; break down problems into simple components; make sound decisions.

Innovative Thinking - Approach problems with curiosity and open-mindedness; offer new ideas, solutions and/or options.

Self-Adaptability - Work in situations involving uncertainty, shifting priorities, and rapid change; deal constructively with mistakes and setbacks; demonstrate flexibility.

Self-Confidence - Recognize own knowledge, skills, and abilities; respond to challenging situations with confidence; understand limits in self.

Team with Others - Initiate, develop, and manage relationships and networks; encourage collaboration and input from all team members; value the contributions of all team members; balance individual and team goals.

Technical/Functional Expertise - Demonstrate technical proficiency required to do the job; possess up-to-date knowledge in the profession; provide technical expertise to others.

Service Orientation
Provide service to our customers, including patients, patient caregivers, referring physicians and each other, in a reliable, responsive, safe, friendly and courteous manner.

* Model safe, ethical behavior, mitigating risk to the institution through sound business practices, and adherence to MD Anderson's Standards of Conduct, institutional policies and procedures.
* Meet time and attendance expectations and responds to requests in a timely manner, communicating expectations for procedures, service arrival, or project deliverables to patients and coworkers.
* Admit when wrong, apologize and take steps to resolve a situation to help patients and coworkers before being asked.

Onsite Presence: Is Required

WORKING CONDITIONS

Frequency

Hazardous Chemicals and Materials

Frequent 34-66%

PHYSICAL DEMANDS

Frequency

Weight

Standing
Walking
Sitting
Reaching
Lifting
Pushing/Pulling
Keyboarding

Frequent 34-66%
Occasionally 11-33%
Constant 67-100%
Occasionally 11-33%
Occasionally 11-33%
Occasionally 11-33%
Frequent 34-66%

5-10 lbs
5-10 lbs

EDUCATION:

Required: PhD in one of the natural sciences or related field or Medical degree.

EXPERIENCE:
Required: Five years experience of relevant research experience in lab.

Preferred: The ideal candidate will have a PhD in Organic Chemistry, postdoctoral experience in organic synthesis and 10-15 years of experience working in biopharma company medicinal chemistry labs. Strong knowledge of contemporary synthetic organic chemistry, with a demonstrated track record of creative independent problem-solving. Strong familiarity with the latest hit-finding techniques, included DNA-encoded libraries, fragment screening and affinity-selection mass spectrometry methods, with demonstrated success moving hits into lead optimization. Skilled experimentalist with demonstrated ability to conduct challenging multi-step organic chemistry synthesis and overcome synthetic hurdles, trained in various purification and analytical techniques. Strong publication record in peer reviewed journals. Familiarity with automated and computational chemistry, including datamining software. Experience mentoring and managing chemists and leading hit-to-lead exercises, as well as knowledge of the drug discovery process, is required. Excellent oral and written communication skills and organizational skills are a must. Familiarity with relevant biological disciplines and ability to integrate knowledge from these areas into the design of new bioactive compounds.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law.

  • Principal Research Scientist Medicinal Chemistry Lead

    4 weeks ago

    Houston, Texas, United States MD Anderson Cancer Center Full time

    Job DescriptionThis Institute Principal Research Scientist (Medicinal Chemistry) will lead cross-functional research to discover lead molecules for progression into novel oncology therapeutic agents that benefit patients. They will be a highly creative synthetic chemist with a strong desire to succeed at the highest level. They will be responsible for the...

  • Research Scientist TX

    5 days ago

    Houston, United States Select Chemistry Full time

    RESEARCH SCIENTISTBelow covers everything you need to know about what this opportunity entails, as well as what is expected from applicants.Job DetailsFull Time / Part Time: Full TimeFLSA Classification: ExemptBusiness Unit: ChemistryReports to: Sr. DirectorTravel Requirement: No Job Description Select Chemistry is seeking a motivated professional with...

  • Research Scientist TX

    4 days ago

    Houston, United States Select Chemistry Full time

    RESEARCH SCIENTISTBelow covers everything you need to know about what this opportunity entails, as well as what is expected from applicants.Job DetailsFull Time / Part Time: Full TimeFLSA Classification: ExemptBusiness Unit: ChemistryReports to: Sr. DirectorTravel Requirement: No Job Description Select Chemistry is seeking a motivated professional with...

  • Research Scientist TX

    6 days ago

    houston, United States Select Chemistry Full time

    RESEARCH SCIENTISTJob DetailsFull Time / Part Time: Full TimeFLSA Classification: ExemptBusiness Unit: ChemistryReports to: Sr. DirectorTravel Requirement: No Job Description Select Chemistry is seeking a motivated professional with innovative thinking and strong technical background. The individual will work in a diverse and multidisciplinary team,...

  • Institute Research Scientist Cell Biology

    5 months ago

    Houston, United States MD Anderson Cancer Center Full time

    MD ANDERSON THERAPEUTICS DISCOVERY DIVISION Within The University of Texas MD Anderson Cancer Center lies a powerful engine driving the future of new targeted, immune- and cell-based therapies: the Therapeutics Discovery Division. Therapeutics Discovery eliminates the bottlenecks that hamper traditional drug discovery, with a multidisciplinary team of...

  • Institute Research Scientist Cell Biology Position

    4 weeks ago

    Houston, Texas, United States MD Anderson Cancer Center Full time

    Job Title: Research Scientist Cell BiologyWe are seeking a highly motivated and talented Research Scientist to join our Reverse Translation group at the MD Anderson Cancer Center. The successful candidate will be a key team member in the organization developing and independently leading research activities to advance projects from target validation through...

  • Research Scientist

    2 weeks ago

    houston, United States Biostate AI Full time

    RESEARCH SCIENTISTHOUSTON, TXWe are currently seeking a Research Scientist to join our team!Biostate.AI aims to build a foundational model of biology that can predict the evolution of health and disease. For each subject, Biostate 's neural network will use past multiomic state information to predict future multiomic states, which in turn can be used to...

  • Research Scientist

    2 weeks ago

    houston, United States Biostate AI Full time

    RESEARCH SCIENTISTHOUSTON, TXWe are currently seeking a Research Scientist to join our team!Biostate.AI aims to build a foundational model of biology that can predict the evolution of health and disease. For each subject, Biostate 's neural network will use past multiomic state information to predict future multiomic states, which in turn can be used to...

  • Principal Data Scientist

    4 weeks ago

    Houston, Texas, United States MD Anderson Center Full time

    Job Title: Principal Data Scientist - AI Innovation LeaderAbout the Role:We are seeking a highly skilled Principal Data Scientist to lead the development and support of innovative generative AI models across the organization. As a key member of our data science team, you will be responsible for developing individual and comprehensive multi-modal foundational...

  • Research Scientist

    3 weeks ago

    Houston, United States Biostate AI Full time

    RESEARCH SCIENTISTHOUSTON, TXWe are currently seeking a Research Scientist to join our team!Biostate.AI aims to build a foundational model of biology that can predict the evolution of health and disease. For each subject, Biostate 's neural network will use past multiomic state information to predict future multiomic states, which in turn can be used to...

  • Research Scientist

    2 weeks ago

    Houston, United States Biostate AI Full time

    RESEARCH SCIENTISTHOUSTON, TXWe are currently seeking a Research Scientist to join our team!Biostate.AI aims to build a foundational model of biology that can predict the evolution of health and disease. For each subject, Biostate 's neural network will use past multiomic state information to predict future multiomic states, which in turn can be used to...

  • Clinical Research Fellow 0

    4 weeks ago

    Houston, United States Houston Methodist Academic Institute Full time

    At Houston Methodist, the Clinical Research Fellow position is responsible for performing clinical research of a complex nature; plans, executes and completes clinical research projects under the supervision/direction of a Principal Investigator. This position provides structured education and first-hand applied experiences in such topics as epidemiology,...

  • Research Coordinator I

    3 weeks ago

    Houston, United States Houston Methodist Academic Institute Full time

    At Houston Methodist, the Research Coordinator position is responsible for coordinating the day-to-day activities of research protocols under the direct supervision of a Principal Investigator and Clinical Trials Manager. This position involves assessing and determining qualification of patients for research studies as well as ensuring accurate data...

  • Research Coordinator I

    3 weeks ago

    Houston, United States Houston Methodist Academic Institute Full time

    At Houston Methodist, the Research Coordinator position is responsible for coordinating the day-to-day activities of research protocols under the direct supervision of a Principal Investigator and Clinical Trials Manager. This position involves assessing and determining qualification of patients for research studies as well as ensuring accurate data...

  • Research Scientist

    1 month ago

    Houston, Texas, United States University Of Houston Full time

    Faculty Position in Synthetic Inorganic ChemistryThe Department of Chemistry at the University of Houston invites applications for a tenure-track assistant professor position in synthetic inorganic chemistry. As a key member of our faculty, you will be expected to teach undergraduate and graduate-level courses, conduct innovative research, and contribute to...

  • Research Coordinator II

    4 weeks ago

    Houston, United States Houston Methodist Academic Institute Full time

    At Houston Methodist, the Research Coordinator II position is responsible for coordinating the day-to-day activities of research protocols as well as assessing and determining qualification of patients for research studies. Under minimal supervision, this position is responsible for ensuring accurate data collection, documentation, organization and safety of...

  • Molecular Research Scientist

    1 month ago

    Houston, Texas, United States MD Anderson Cancer Center Full time

    Job SummaryWe are seeking a highly motivated and experienced Molecular Research Scientist to join our team at the MD Anderson Cancer Center. The successful candidate will be responsible for conceiving, developing, and implementing innovative molecular, cellular, and tissue-based studies that align with the mission goals of the Department of Pediatrics -...

  • Clinical Research Nurse

    3 weeks ago

    Houston, United States Houston Methodist Academic Institute Full time

    At Houston Methodist, the Clinical Research Nurse (CRN) position is licensed clinician who is responsible for, with minimal supervision, supporting, facilitating and coordinating the daily clinical trial activities and plays a critical role in the conduct of the study. This position functions at the Competent level according to the Benner's model of clinical...

  • Clinical Research Nurse

    2 weeks ago

    Houston, United States Houston Methodist Academic Institute Full time

    At Houston Methodist, the Clinical Research Nurse (CRN) position is licensed clinician who is responsible for, with minimal supervision, supporting, facilitating and coordinating the daily clinical trial activities and plays a critical role in the conduct of the study. This position functions at the Competent level according to the Benner's model of clinical...

  • Clinical Research Nurse

    3 weeks ago

    Houston, United States Houston Methodist Academic Institute Full time

    At Houston Methodist, the Clinical Research Nurse (CRN) position is licensed clinician who is responsible for, with minimal supervision, supporting, facilitating and coordinating the daily clinical trial activities and plays a critical role in the conduct of the study. This position functions at the Competent level according to the Benner's model of clinical...