Antibody Discovery- In Vitro, Director, Global Biologics

4 weeks ago

BOSTON Massachusetts, Middlesex County, MA, United States Takeda Pharmaceutical Full time

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

About the role:

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.

Join Takeda as an Antibody Discovery- In Vitro, Director where you will be an excellent addition to our fast paced and exciting team of committed scientists, using your depth and breadth of knowledge in the field of antibody discovery, optimization and progression of programs forward through discovery towards IND. With your experience and expertise in antibody discovery and optimization, you will lead biologics programs from early discovery, through candidate selection, to IND and be accountable for the performance and results of a significant research function or activity that incorporates in vitro based discovery platforms yeast and phage. As part of the Biotherapeutic Engineering Team, you will report to the Senior Director and work with the Global Biologics organization as a leader who has accountability for the performance and results of a significant research function or activity that incorporates in vitro based discovery platforms yeast and phage.

How you will contribute:

Scientific leader:

  • Set high standards for effectiveness of execution, and rigor of thought. Posses in-depth knowledge of antibody-based discovery, optimization/ engineering using in vitro based discovery methods such as yeast, phage, or mammalian display.
  • Experience in appropriately mining and triaging of antibody repertoires, to progress viable therapeutic molecules.
  • Draw on expertise from in vitro based discovery platforms to provide thoughtful guidance on strategies towards candidate profiles for differing target types, optimization / engineering approaches to enhance properties to progress from lead to candidate.
  • Incorporate NGS and Sanger based sequence analysis for both repertoires and clonal populations.
  • Identify and drive efficient paths for workflow progression.
  • Drive research strategy within the sub-team and foster innovation.
  • Contribute to deepening of the expertise through external network development, evaluating new opportunities in partnership with business development.

Program Leader

  • Lead biologics programs from discovery to IND, integrating early research, progression through candidate nomination and selection.
  • Detailed knowledge of full biologics process from discovery to pre-IND.
  • Ambassador for the biologics department, scientifically inputting to the project teams.
  • Exceptionally collaborative mindset, working with internal /external groups for high efficiency and transparency to enable swift progression of molecules.

People Leader

  • Organizational leader accountable for the performance and results of this significant research function with significant managerial responsibility.
  • Use enterprise mindset with a broad view across the portfolio that informs resourcing and prioritization of programs under direct remit.
  • Empowerment to lead a small team of highly qualified and skilled scientists in their mission to generate therapeutic biologics.
  • Develop the next generation of organizational and project leaders, being a champion of new opportunities. Team-centric mindset, inspiring and growing team members, while serving as a role model and mentor.
  • Responsible for effective resourcing within team to drive programs forward in and efficient manner.
  • Lead team through in-lab presence, designing and efficiently executing discovery /optimization campaigns including affinity maturation, developability; technology development.

Other

  • Excellent knowledge of data analysis tools to ensure thorough evaluation of datasets and information based next step decisions.
  • High level of diligence in all data tracking, uploading, and recording using data management systems within the department.
  • Key involvement and due diligence for external interactions, collaborations and workflows where appropriate.
  • Contribute to the preparation of patents, documentation for IND, and publications.

Minimum Requirements/Qualifications:
  • PhD degree in a scientific discipline with 10+ years experience , or MS with 16+ years experience, or BS with 18+ years experience.
  • 9 years of Industry experience required.
  • 9 years of managerial experience required.
  • Outstanding expertise and depth of knowledge within a scientific area.
  • Keeps up with the up-to-date scientific advancement (e.g. competitive landscape, new technology, new research portfolio, and new partnership).
  • Independently manages workload and expectations.
  • Scientifically independent.
  • Scientific driver for research strategy that impacts group internally and outside area of function.

More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

#LI-SGM

#LI-Onsite

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Boston, MA

U.S. Base Salary Range:

169,400.00 - 266,200.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and

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