Scientist, DMPK

2 weeks ago


Cambridge Massachusetts, United States Biogen Full time
Job Description

About This Role

Biogen is seeking a highly motivated scientist with excellent knowledge and experience in LC-MS/MS bioanalysis to join the Drug Metabolism and Pharmacokinetics (DMPK) department. The candidate will be responsible for bioanalytical support of discovery and development programs, including small molecule compounds and oligonucleotides. Experience in regulated bioanalysis and GLP studies is preferred. The candidate should be able to effectively manage and prioritize multiple projects to ensure timely support of the projects. Excellent communication and interpersonal skills are required, along with scientific thinking and problem-solving skills.

What You’ll Do

Develop new bioanalytical methods for quantification of small molecule compounds and oligonucleotides (ASO, siRNA etc.) in biological matrices. 

Analyze biological samples (plasma, CSF, tissue etc.) and timely deliver high quality bioanalytical data to support non-clinical and possible clinical studies.

Oversee non-GLP and GLP bioanalytical activities at CROs. Provide scientific guidance on method transfer/development, qualification/validation, and sample analysis at CROs.

Write and review study protocols and bioanalytical reports that are suitable for inclusion in registration dossiers.

Manage multiple projects within timelines according to high scientific and ethical standards.

Evaluate and implement new bioanalytical technologies for solving DMPK challenges or project needs.

Publish scientific papers and present at external scientific meetings.

Who You Are

You love bioanalysis and are passionate about applying bioanalysis to impact drug discovery and development. You love learning new technological skills and working through collaboration.

 



  • Cambridge, United States Editas Medicine Full time

    Job DescriptionJob DescriptionAt Editas, we’re driven by a collective purpose, to bring transformative and life changing therapies to people living with serious diseases with the greatest unmet needs. This fuels our drive to excel in scientific innovation, allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing....

  • Senior Director, DMPK

    2 hours ago


    Cambridge, United States Editas Medicine Full time

    Job DescriptionJob DescriptionAt Editas, we’re driven by a collective purpose, to bring transformative and life changing therapies to people living with serious diseases with the greatest unmet needs. This fuels our drive to excel in scientific innovation, allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing....

  • Sr. Scientist

    1 month ago


    Cambridge, Massachusetts, United States MOMA Therapeutics Full time

    MOMA Therapeutics is looking for an experienced Sr. Scientist/Principal Scientist, Computational ChemistryUnlocking a new target class in drug discovery is no small task: it requires computation to transform data into insights; it requires scientific and technological excellence; it demands a culture of focus, resilience, creativity, and collaboration; and...


  • Cambridge, Massachusetts, United States MOMA Therapeutics Full time

    MOMA Therapeutics is looking for an experienced Sr. Scientist/Principal Scientist, Computational Chemistry About MOMA TherapeuticsUnlocking a new target class in drug discovery is no small task: it requires computation to transform data into insights; it requires scientific and technological excellence; it demands a culture of focus, resilience, creativity,...


  • Cambridge, United States MOMA Therapeutics Full time

    Job DescriptionJob DescriptionMOMA Therapeutics is looking for an experienced Sr. Scientist/Principal Scientist, Computational Chemistry About MOMA TherapeuticsUnlocking a new target class in drug discovery is no small task: it requires computation to transform data into insights; it requires scientific and technological excellence; it demands a culture of...


  • Massachusetts, United States AstraZeneca plc Full time

    **Global Biotransformation Leader (Associate Director / Director ~ DMPK Oncology R&D)****Permanent Opportunity****Location: Cambridge, UK / Waltham, US** **ABOUT ASTRAZENECA** AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of...


  • Cambridge, United States Relay Therapeutics, Inc. Full time

    The Opportunity: * Does delivering a great development candidate thrill you? That's what we live for, too, and we aim to build the best environment in the industry to discover the drugs that will make a difference for patients. We are looking for a self-motivated, creative, and experienced medicinal chemist to join our team and help drive projects from lead...


  • Cambridge, United States Third Rock Ventures Full time

    The Opportunity: * Does delivering a great development candidate thrill you? That's what we live for, too, and we aim to build the best environment in the industry to discover the drugs that will make a difference for patients. We are looking for a self-motivated, creative, and experienced medicinal chemist to join our team and help drive projects from lead...


  • Cambridge, United States FogPharma Full time

    Why Join Us? FogPharma is a biopharmaceutical company pioneering the discovery and development of Helicon therapeutics, which are peptides capable of efficient cell entry and modulation of both protein-protein and protein-DNA interactions. Through Helicon therapeutics, FogPharma is poised to revolutionize the medical possibilities for patients by precisely...


  • Cambridge, United States Moderna Theraputics Full time

    The Role: Moderna is seeking an innovative, highly collaborative, strategic, and effective translational medicine leader to establish the translational medicine function for our exciting and transformational rare disease mRNA therapeutics pipeline. This position is based in the new Translational Medicine function in our growing Therapeutics & Oncology...


  • Cambridge, United States FogPharma Full time

    Job DescriptionJob Description Why Join Us?FogPharma is a biopharmaceutical company pioneering the discovery and development of Helicon™ therapeutics, which are peptides capable of efficient cell entry and modulation of both protein-protein and protein-DNA interactions. Through Helicon therapeutics, FogPharma is poised to revolutionize the medical...


  • Cambridge, United States BioSpace Full time

    Job DetailsThe Role:Moderna is seeking an innovative, highly collaborative, strategic, and effective translational medicine leader to establish the translational medicine function for our exciting and transformational rare disease mRNA therapeutics pipeline. This position is based in the new Translational Medicine function in our growing Therapeutics &...


  • Cambridge, United States Moderna, Inc. Full time

    The Role:Moderna is seeking an innovative, highly collaborative, strategic, and influential translational medicine leader for our innovative and expanding Oncology mRNA therapeutics pipeline. In this role, you will guide and lead a team to develop robust plans to thoroughly understand mechanism of action, pharmacology, tissue localization/targeting, and...


  • Cambridge, United States Moderna, Inc. Full time

    The Role:Moderna is seeking an innovative, highly collaborative, strategic, and effective translational medicine leader to establish the translational medicine function for our exciting and transformational rare disease mRNA therapeutics pipeline. This position is based in the new Translational Medicine function in our growing Therapeutics & Oncology...


  • Cambridge, United States Moderna, Inc. Full time

    The Role:Moderna is seeking an innovative, highly collaborative, strategic, and effective translational medicine leader to establish the translational medicine function for our exciting and transformational rare disease mRNA therapeutics pipeline. This position is based in the new Translational Medicine function in our growing Therapeutics & Oncology...


  • Cambridge, Massachusetts, United States Moderna, Inc. Full time

    The Role:Moderna is seeking an innovative, highly collaborative, strategic, and effective translational medicine leader to establish the translational medicine function for our exciting and transformational rare disease mRNA therapeutics pipeline. This position is based in the new Translational Medicine function in our growing Therapeutics & Oncology...


  • Cambridge, Massachusetts, United States Moderna, Inc. Full time

    The Role:Moderna is seeking an innovative, highly collaborative, strategic, and influential translational medicine leader for our innovative and expanding Oncology mRNA therapeutics pipeline. In this role, you will guide and lead a team to develop robust plans to thoroughly understand mechanism of action, pharmacology, tissue localization/targeting, and...