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Executive Director, Translational Medicine, Oncology
4 months ago
The Role:
Moderna is seeking an innovative, highly collaborative, strategic, and influential translational medicine leader for our innovative and expanding Oncology mRNA therapeutics pipeline. In this role, you will guide and lead a team to develop robust plans to thoroughly understand mechanism of action, pharmacology, tissue localization/targeting, and patient population for promising experimental therapeutics, and inform mRNA platform learnings. The ideal candidate will have an advanced degree(s), and pharmaceutical and/or significant biotechnology experience developing drug candidates in the clinic, and experience developing oncology drugs. Experience in the development and submission of documents to health authorities and response to health authority inquiries a plus. This important leadership role will partner with a talented and highly cross functional matrix team comprised of program leaders, medical directors, nonclinical and DMPK scientists, discovery research scientists, regulatory, clinical operations, clinical pharmacology and pharmacometrics, program management, and clinical biomarker assay partners to develop and execute the translational strategy to ensure and accelerate robust and successful clinical development, inform go/no go decision making, successful health authority filings, program differentiation, scientific publications, post-marketing and lifecycle support as needed. The candidate will be a highly effective internal and external team player, communicator, and collaborator.
The ideal candidate will be a scientific innovator, problem solver, exceptional matrix and people leader, and thrive in our proactive mission driven, can-do culture that removes viscosity wherever possible to help advance our medicines with speed and rigor to patients with high unmet medical needs. This position is ideally based in our Cambridge, MA headquarters. Approximately 10% travel is expected in this role.
Heres What Youll Do:
Develop and implement the translational medicine strategy for Oncology programs across the portfolio, including developing and communicating translational questions, hypotheses, recommendations regarding study design, endpoints (including novel endpoints), diagnostic strategy, safety evaluation, dose, pharmacology and PD biomarkers Develop, coach, and grow translational scientific leaders to increase their impact on our programs Serve as a strategic development partner for Program Team Leads to ensure efficient development and implementation of all key translational deliverables and provides frequent project status updates to the cross-functional development teams Work with key matrix partner functions to define our integrated development plans, including the assessment of unmet medical need, proposal of clinical development pathways, and interpretation of preclinical data to aid in clinical study design Work vertically across Research and Development to define the clinical translational strategy and delivery plan well in advance of IND submission to ensure future program readiness and success Develop and lead the reverse translation of our clinical studies to better enable research and development, as well as platform learnings Identify and work to validate novel endpoints for early go/no go decision making, accelerated approvals, and refine clinical study patient populations to support rapid demonstration of safety and efficacy and clinical proof of concept Provide translational leadership to early and late development project teams Work closely with scientists in research and with biomarker experts in development to align preclinical and clinical biomarker strategies to meet or exceed program needs Consult with external and internal subject matter experts to all major go/no-go development decision criteria to enable best decisions for the program. Partner with Clinical Biomarkers Lead(s) to define an implementable biomarker assay strategy for clinical stage programs, including design and writing, as well as authoring the biomarker sections of Investigator Brochures, Clinical Study Protocols and Reports, program documents, regulatory submissions and responses (INDs/CTAs) as well as co-authoring, assisting and supporting the development of publications, abstracts, and presentations. Partner with biostatisticians, computational, and biomarker experts to ensure delivery and interpretation of high-quality data to support internal decision-making and health authority filings Must be able to manage multiple projects and deliverables across R&D, including assessment of workload, prioritization, and resourcing requirements to deliver the program teams objectives As a member of the translational medicine leadership team, shape the future of the translational medicine function at Moderna Heres What Youll Bring to the Table: Advanced scientific degree (MD, PhD, DVM, PharmD), with a minimum of 8 years of relevant work experience developing translational medicine strategies, developing and testing hypotheses in the clinic, biomarker identification and development, biomarker data interpretation A strong background in translational medicine, biomarker identification, experimental design, clinical biomarker data analysis and interpretation, development of high impact scientific publications A robust external network of scientific thought leaders and biomarker partner relationships Proficiency in emerging diagnostic and biomarker technologies Outstanding verbal and written communication skills, problem solving, and excellent interpersonal partnering and influence skills, ability to mentor scientists around the enterprise Demonstrated track record in leading successful cross-functional teams and work streams that overcome obstacles to deliver for the enterprise A thorough understanding of the drug development process, including non-clinical and clinical study design, preclinical experiments, clinical protocol development, clinical study delivery, clinical study reports Experience partnering with commercial and medical affairs to develop translationally informed target product profiles and medical education Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:Highly competitive and inclusive medical, dental and vision coverage optionsFlexible Spending Accounts for medical expenses and dependent care expensesLifestyle Spending Account funds to help you engage in personal enrichment and self-care activitiesFamily care benefits, including subsidized back-up care options and on-demand tutoringFree premium access to fitness, nutrition, and mindfulness classesExclusive preferred pricing on Peloton fitness equipmentAdoption and family-planning benefitsDedicated care coordination support for our LGBTQ+ communityGenerous paid time off, including:Vacation, sick time and holidays
Volunteer time to participate within your community
Discretionary year-end shutdown
Paid sabbatical after 5 years; every 3 years thereafterGenerous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents 401k match and Financial Planning toolsModerna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit optionsComplimentary concierge service including home services research, travel booking, and entertainment requestsFree parking or subsidized commuter passesLocation-specific perks and extras About Moderna Since our founding in 2010, we have aspired to build the leading mRNA technology platform, theinfrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world. By living our mission, values, and mindsets every day, our peopleare the driving force behind our scientific progress and our culture.Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities.
We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. As we build our company, we have always believed an in-person culture is critical to our success. Moderna champions the significant benefits of in-office collaboration by embracing a 70/30 work model. This 70% in-office structure helps to foster a culture rich in innovation, teamwork, and direct mentorship. Join us in shaping a world where every interaction is an opportunity to learn, contribute and make a meaningful impact.
If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit to learn more about our current opportunities.
Moderna is a smoke-free, alcohol-free and drug-free work environment.
Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply
Moderna is proud to be an equal opportunity workplace and is an affirmative action employer.
Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law. Moderna is an E-Verify Employer in the United States. We also consider qualified applicants regardless of criminal histories, consistent with legal requirements.
Belonging, Inclusion, and Diversity are critical to the success of our company and our impact on society. Were focused on attracting, retaining, developing, and advancing our employees and believe that by cultivating diverse experiences, backgrounds, and ideas, we can provide an environment where every employee is able to contribute their best.
Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should contact the Accommodations team at (EEO/AAP Employer)
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