Senior Scientist I

4 weeks ago


Worcester Massachusetts, United States AbbVie Full time
Job Description

The Senior Scientist I will play a key role in the developing downstream purification process development for various modalities such as mAbs, ADCs, bio-specifics, gene therapy, etc. Ideal candidate will conceive and implement novel experimental and/or modeling approaches to answer scientific questions. The mission of this team is to address challenging problems in biologics development areas by working collaboratively and cross-functionally by developing appropriate tools and technologies to enable right at first pass scale-up and technology transfer of various biologics modalities drug substance processes.

Responsibilities:

Develop recovery and purification process that utilizes clarification, chromatography, and membrane filtration technologies for monoclonal antibodies, bio-specifics and antibody drug conjugates (ADC).

Proactively seek opportunities to come up with innovative solutions to cater challenging business problems through creative solutions.

Design and execute process development and characterization activities, impurity and viral clearance studies.

Provide deeper understanding of process performance using appropriate experimental and modeling tools.

Responsible for technology transfer to pilot lab and cGMP manufacturing facilities, troubleshooting and investigation activities.

Harness power of strong fundamentals to come up with innovative process and/or equipment designs in a strongly collaborative environment.

Build experimentally verified fit for purpose mathematical models for downstream purification processes.

Routinely demonstrate scientific initiative and creativity in research or development activities.

Exhibit a strong motivation to implement and advance various innovative technologies in relevant areas across AbbVie.

Highly independent and productive in performing laboratory research or method development, requiring only minimal direction from or interaction with supervisor.

Formulate conclusions and design follow-on experiments based on multidisciplinary data.

A primary author of publications, presentations, regulatory documents and/or primary inventor of patents.

Maintain a high level of productivity in the lab and/or pilot plant and cGMP manufacturing facilities.

Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, controlled drug and radioactive compounds, GxP compliance, and animal care where applicable.No description available


  • Senior Scientist I

    3 weeks ago


    Worcester, Massachusetts, United States AbbVie Full time

    Job Description Key Responsibilities   Responsible for developing, optimizing & executing new analytical methods & techniques to characterize complex proteins/glycoproteins, antigens & novel protein-based therapeutics. Work within multi-disciplinary project teams & act as a lead analytical & biophysical resource to guide development & advance...


  • Worcester, United States AbbVie, Inc Full time

    Company Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services...


  • Worcester, United States EdenRoc Sciences Full time

    Metro International BioTech, a subsidiary of EdenRoc Sciences, LLC, is a fast-paced, privately held, therapeutics start-up headquartered in Worcester, MA. Our mission is the discovery and development of innovative therapies that ameliorate chronic diseases associated with human aging.As a Senior Scientist, Oncology at MetroBiotech, you will:Develop and...


  • Cambridge, Massachusetts, United States Editas Medicine Full time

    At Editas, we’re driven by a collective purpose, to bring transformative and life changing therapies to people living with serious diseases with the greatest unmet needs. This fuels our drive to excel in scientific innovation, allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing. We believe our people are at...


  • Boston, Massachusetts, United States Square Full time

    Job Description We are looking for a Data Scientist to join our Risk Data Science and Analytics Team. You will improve our risk controls through advanced statistical and analytical techniques. You will also manage core operational metrics, advise senior stakeholders on Risk controls, and build processes to root out high-risk activity across the Square...


  • Cambridge, Massachusetts, United States Biogen Full time

    Job Description About This Role Biogen is searching for a biophysicist to fill a Senior Scientist position within the Analytical Development (AD) – Biologics/Advanced Therapies & Medicinal Products (ATMP) department in Cambridge, MA. This key technical leadership role will lead the biophysical and higher-order-structure characterization for biologics...

  • Project Manager I

    1 week ago


    Worcester, Massachusetts, United States University of Massachusetts Medical School Full time

    Overview: POSITION SUMMARY:  Under the direction of the Director or designee, the Project Manager I leads small projects or subcomponents of larger, more complex projects. The Project Manager I is responsible for independent action on multiple projects as assigned.  Tasks vary according to the priorities of the department. Responsibilities: ESSENTIAL...

  • R&D Associate I

    2 weeks ago


    Worcester, Massachusetts, United States University of Massachusetts Medical School Full time

    Overview: GENERAL SUMMARY OF POSITION:  The R&D Associate I - Product Discovery will be responsible for research and/or development to support early discovery and pre-clinical development of novel biotherapeutics. The ideal candidate will function in a cutting-edge laboratory environment as part of a multi-disciplinary team of protein engineers,...

  • Senior Banker I

    2 weeks ago


    Littleton, Massachusetts, United States Middlesex Savings Bank Full time

    Overview: It is the responsibility of the Senior Banker I to represent Middlesex Savings Bank to the public and to their colleagues, and to promote the Bank's core values and mission. They accomplish this by focusing on the customer experience, achievement of operational excellence, achievement of performance goals, solid decision making, and a commitment...


  • Cambridge, Massachusetts, United States AbbVie Full time

    Job Description We are seeking an experienced and highly motivated Senior Scientist I to provide scientific, operational, and logistical support for implementing biomarker strategies in multiple neurology and neuropsychiatry, psychiatry clinical development programs. Biomarkers will span brain function and non-soluble modalities including neuroimaging,...


  • Worcester, Massachusetts, United States AbbVie Full time

    Job Description The Precision Medicine Department at Abbvie is committed to advancing drug development and patient care through building a deeper understanding of disease biology and developing tools to optimize clinical decision making and customize treatment for individual patients. Abbvie is seeking a highly motivated and experienced translational...


  • Boston, Massachusetts, United States Hillstar Bio Full time

    About the Company Hillstar Bio, a precision immunology company that recently completed a sizable Series A financing with a syndicate of blue chip investors (Droia, Frazier, Novo, LifeArc). Hillstar aspires to build a portfolio of programs against autoimmune diseases with unmet or underserved medical needs. Its lead program is an antibody designed to...


  • Cambridge, Massachusetts, United States Biogen Full time

    Job Description About This Role Translational In Vivo Sciences (TIVS) at Biogen is seeking a Senior Associate Scientist to join a cross-functional research effort to enhance the delivery of Biogen’s therapeutics to the central nervous system (CNS) and muscle. These efforts will be applied across multiple therapeutic areas in the neurological and...

  • Research Associate I

    2 weeks ago


    Worcester, Massachusetts, United States University of Massachusetts Medical School Full time

    Overview: POSITION SUMMARY:  The Department of Pathology at UMass Chan Medical School located in Worcester, Massachusetts, invites applications for Research positions at the Research Technician or Research Associate level. We are seeking individuals with a BA/BS in a Biological/Life Sciences. The ideal candidate would have a background in Immunology,...

  • Senior Scientist

    1 week ago


    Bedford, Massachusetts, United States Werfen Full time

    Overview: Werfen   Werfen is a growing, family-owned, innovative company founded in 1966 in Barcelona, Spain.  We are a worldwide leader in specialized diagnostics in the areas of Hemostasis, Acute Care Diagnostics, Transfusion, Autoimmunity, and Transplant. Through our Original Equipment Manufacturing (OEM) business line, we research, develop, and...


  • Cambridge, Massachusetts, United States AbbVie Full time

    Job Description The Immunology Discovery Department is seeking an experienced and accomplished Scientist to lead the Tissue-Resident T cell Group within the Immune Tolerance Therapeutics Discovery team based in Cambridge MA. In this role you will lead a multidisciplinary team of highly talented scientists with expertise in both in vitro and in vivo models...


  • Worcester, United States Fallon Community Health Plan Full time

    The Revenue Senior Account I is a strategic partner to management across the organization. The role requires proficiency in the development, accumulation, and evaluation of key elements necessary to properly report the financial position of the organ Accountant, Revenue, Senior, Accounting, Microsoft, Operations, Healthcare


  • Worcester, United States Yurogen Biosystems LLC Full time

    Yurogen Biosystems LLC, a rapidly expanding biotechnology company, is seeking an energetic and self-motivated individual with extensive experience in biochemistry, molecular biology, or protein science. As part of our dynamic team, you will collaborate with talented scientists to drive projects related to mAb and protein development and production. We are...


  • Worcester, United States Yurogen Biosystems LLC Full time

    Yurogen Biosystems LLC, a rapidly expanding biotechnology company, is seeking an energetic and self-motivated individual with extensive experience in biochemistry, molecular biology, or protein science. As part of our dynamic team, you will collaborate with talented scientists to drive projects related to mAb and protein development and production. We are...

  • Research Associate

    2 weeks ago


    Worcester, Massachusetts, United States University of Massachusetts Medical School Full time

    Overview: POSITION SUMMARY:  The Department of Pathology at UMass Chan Medical School located in Worcester, Massachusetts, invites applications for Research positions at the Research Technician or Research Associate IV level. We are seeking individuals with a BA/BS in a Biological/Life Sciences. The ideal candidate would have a background in Immunology,...