Scientist/Senior Scientist, Protein Analytics

2 weeks ago

Boston Massachusetts, United States Hillstar Bio Full time
About the Company

Hillstar Bio, a precision immunology company that recently completed a sizable Series A financing with a syndicate of blue chip investors (Droia, Frazier, Novo, LifeArc).

Hillstar aspires to build a portfolio of programs against autoimmune diseases with unmet or underserved medical needs. Its lead program is an antibody designed to selectively target a root cause of Cold Agglutinin Disease (CAD) and Systemic Lupus Erythematosus (SLE). CAD is a chronic, rare (incidence 15/million) but debilitating condition with high morbidity (anemia, fatigue, cold-induced circulatory symptoms). SLE on the other hand, affects an estimated 3 million adults worldwide, with symptoms affecting various organs including joints, kidneys, blood cells, brain, heart, and lungs. Existing treatment options for CAD and SLE have limited effectiveness, carry considerable safety risks, and fail to address key disease symptoms in a large proportion of patients, leading to significant chronic morbidity and excess mortality. By bringing this new precision modality to patients, Hillstar aims to improve on safety and efficacy, as well as durability of response, setting a new gold standard for the management of CAD, SLE, and potentially other serious autoimmune conditions with a common biological origin.

Job Description

Join Hillstar Bio as a protein analytics leader performing antibody characterization, developability assessment, pre-formulation and DS/DP releasing assays, and working with a skilled team towards achieving our first IND milestone. Establish platforms of antibody characterization, developability assessment, formulation, protein QC and DS/DP specification. Develop and delineate distinctive protein analytics strategies of programs by corroboration with antibody discovery, immunology and CMC groups.

This pivotal role offers opportunities to shape our company culture, contribute to organization growth, and make a significant impact on treatment of autoimmune disease to benefit patients. We seek an enthusiastic scientist with extensive hands-on experience, broad knowledge in a variety of advanced biophysical characterization techniques, and strong cross-functional collaborative mindset in a fast-paced environment.

Key duties and accountability

•         This position is for a bench scientist, requiring a commitment of over 60% of your time in the laboratory.

•         Perform reagent QC, biophysical and biochemical protein characterization and antibody developability/manufacturability assessment in all stages of antibody development.

•         Perform formulation and stability study.

•         Manage analytical method development and validation under ICH guideline.

•         Establish DS/DP specifications.

•         Lead development candidate (DC) nomination.

•         Interpret results and communicate within Antibody Research and cross-functional colleagues for successful execution/completion of project.

•         Identify, evaluate, and implement new and existing technologies to improve protein characterization capabilities, throughput, and quality.

•         Maintain detailed laboratory notebooks and write SOPs.

•         Monitor, maintain, and calibrate laboratory instruments and equipment.

•         Proactively share skills and knowledge and train others on techniques and protocols.

Requirements

Qualifications

•         MS or PhD in Biochemistry, Biology, or a related field with at least 5+ years (MS) or 2+ years (PhD) of relevant industrial experience in protein analytics and characterization

•         Expertise in affinity determination and epitope binning using Octet, ELISA, and SPR.

•         Strong hands-on experience in protein biophysical characterization techniques such as DSF, DSC, SEC-MALS, DLS, Octet, CE, icIEF, HPLC-based assays (SEC, HIC, IEX, etc.)

•         Experience with ELISA-based specificity screening of mAbs (PSR, DNA, insulin, serum binding assays) is desirable.

•         Experience in CMC management of analytical method validation.

•         Experience with DS/DP GMP stability study and specification.

•         Experience with Flow cytometry is a plus.

•         Master in the efficient execution of highly robust, reproducible, well-documented laboratory experiments and results reporting.

•         Ability to establish and troubleshoot experiments.

•         Excellent organizational and time-management skills with strong attention to detail is a must.

•         Ability to thrive in a highly collaborative, fast-paced, team-oriented environment with colleagues from diverse disciplines.

Benefits

Compensation and Benefits

Hillstar Bio offers a competitive compensation and benefits package, including a competitive salary, equity, and a comprehensive benefits package.

Additional Information

This is a full-time position located in our Boston, MA office. We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

  • Scientist/Senior Scientist, Protein Analytics

    2 weeks ago

    Boston, United States Hillstar Bio Full time

    Job DescriptionJob DescriptionAbout the CompanyHillstar Bio, a precision immunology company that recently completed a sizable Series A financing with a syndicate of blue chip investors (Droia, Frazier, Novo, LifeArc).Hillstar aspires to build a portfolio of programs against autoimmune diseases with unmet or underserved medical needs. Its lead program is an...

  • Scientist/Senior Scientist, Protein Analytics

    5 days ago

    Boston, United States Hillstar Bio Full time

    About The CompanyHillstar Bio, is a precision immunology company that recently completed a sizable Series A financing with a syndicate of blue-chip investors. Our passionate team of drug developers is based in Boston's Seaport neighborhood.Hillstar is advancing a portfolio of programs against autoimmune diseases with unmet or underserved medical needs. Its...

  • Scientist/Senior Scientist, Protein Analytics

    6 days ago

    Boston, United States Hillstar Bio Full time

    About The CompanyHillstar Bio, is a precision immunology company that recently completed a sizable Series A financing with a syndicate of blue-chip investors. Our passionate team of drug developers is based in Boston's Seaport neighborhood.Hillstar is advancing a portfolio of programs against autoimmune diseases with unmet or underserved medical needs. Its...

  • Scientist/Senior Scientist, Protein Analytics

    6 days ago

    Boston, United States Hillstar Bio Full time

    About The CompanyHillstar Bio, is a precision immunology company that recently completed a sizable Series A financing with a syndicate of blue-chip investors. Our passionate team of drug developers is based in Boston's Seaport neighborhood.Hillstar is advancing a portfolio of programs against autoimmune diseases with unmet or underserved medical needs. Its...

  • Scientist/Senior Scientist, Protein Analytics

    5 days ago

    Boston, United States Hillstar Bio Full time

    Job DescriptionJob DescriptionAbout the CompanyHillstar Bio, is a precision immunology company that recently completed a sizable Series A financing with a syndicate of blue-chip investors. Our passionate team of drug developers is based in Boston’s Seaport neighborhood. Hillstar is advancing a portfolio of programs against autoimmune diseases with unmet or...

  • Scientist/ Senior Scientist

    1 day ago

    Boston, United States Elektrofi Full time

    ABOUT ELEKTROFI Elektrofi is a biopharmaceutical formulation technology company that is revolutionizing the delivery of biologic therapies by giving patients the ability to control how they want to receive and benefit from life-changing medicines. Our breakthrough ultra-high concentration microparticle technology platform resolves the limitations associated...

  • Senior Scientist I

    1 day ago

    Massachusetts, United States AbbVie Full time

    Company DescriptionAbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our...

  • Senior Scientist

    16 hours ago

    Boston, United States Fable Therapeutics Full time

    Senior Scientist - Antibody Discovery and Protein Interactions, Fable TherapeuticsAbout Us: Fable Therapeutics (Fable) is a discovery-stage biotechnology company which develops purpose-built biologics designed to overcome therapeutic index limitations and channel therapeutic response where and when it matters.Fable is powered by state-of-the-art structure...

  • Associate Scientist or Scientist I, Recombinant Production

    1 day ago

    Massachusetts, United States AbbVie Full time

    Company DescriptionAbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our...

  • Associate/Senior Associate Scientist

    1 day ago

    Boston, United States Elektrofi Full time

    ASSOCIATE/SENIOR ASSOCIATE SCIENTIST ABOUT ELEKTROFI Elektrofi is a biopharmaceutical formulation technology company that is revolutionizing the delivery of biologic therapies by giving patients the ability to control how they want to receive and benefit from life-changing medicines. Our breakthrough ultra-high concentration microparticle technology...

  • Associate Scientist

    1 day ago

    Boston, United States Elektrofi Full time

    ABOUT ELEKTROFI Elektrofi is a biopharmaceutical formulation technology company that is revolutionizing the delivery of biologic therapies by giving patients the ability to control how they want to receive and benefit from life-changing medicines. Our breakthrough ultra-high concentration microparticle technology platform resolves the limitations associated...

  • Associate Scientist/Scientist, Discovery

    1 day ago

    Boston, Massachusetts, United States PepGen Full time

    Associate Scientist/Scientist, DiscoveryPosition SummaryWe are seeking an Associate Scientist/Scientist, Discovery who will report to our Senior Director, Discovery Biology. They will be responsible for executing biochemical and cellular assays to support drug discovery efforts. The ideal candidate will be experienced with the testing of chemical compounds,...

  • Senior Data Scientist

    2 days ago

    Boston, United States Alivia Analytics Full time

    Job DescriptionJob DescriptionSenior Data Scientist Location: Fully Remote (Boston, MA)Overview:Alivia Analytics is seeking a technically adept Data Scientist with a strong foundation in SQL, Python, and machine learning to join our rapidly expanding team focused on combating healthcare fraud. This role demands an individual with a profound ability to...

  • Sr Scientist, Assay Development

    3 weeks ago

    Boston, Massachusetts, United States Foundation Medicine Full time

    About the JobThe Senior Scientist, Assay Development will work as part of a new product team, focused on improving blood-based cancer diagnostic capabilities in areas such as cancer detection, minimum residual disease, and other related applications. This team is comprised of talent from across the Roche ecosystem, including Roche Diagnostics, Roche Pharma...

  • Scientist, Discovery

    4 hours ago

    Boston, United States PepGen Full time

    Job DescriptionJob DescriptionAssociate Scientist/Scientist, DiscoveryPosition SummaryWe are seeking an Associate Scientist/Scientist, Discovery who will report to our Senior Director, Discovery Biology. They will be responsible for executing biochemical and cellular assays to support drug discovery efforts. The ideal candidate will be experienced with the...

  • Principal Research Associate/Associate Scientist, Cell Biology

    4 weeks ago

    Boston, United States Magnet Biomedicine Full time

    Principal Research Associate/Associate Scientist, Cell Biology About Magnet Biomedicine Magnet Biomedicine is a fast-paced, collaborative, venture-backed startup developing rational approaches to molecular glue discovery. Magnet's TrueGlueTM Discovery Platform enables the discovery and development of fit-for-purpose molecular glue strategies to target a...

  • Research Scientist

    6 days ago

    Boston, United States Massachusetts General Hospital(MGH) Full time

    **Research Scientist** - (3291132) GENERAL SUMMARY/OVERVIEW: The Wein laboratory investigates molecular mechanisms used by parathyroid hormone to exert its function in target cells in bone and other tissues. We employ wide-ranging techniques to study parathyroid hormone signaling in vitro and in vivo. These studies will lead to an improved understanding of...

  • Scientist, Discovery

    16 hours ago

    Boston, United States PepGen Full time

    Position SummaryWe are seeking an Associate Scientist/Scientist, Discovery who will report to our Senior Director, Discovery Biology. They will be responsible for executing biochemical and cellular assays to support drug discovery efforts. The ideal candidate will be experienced with the testing of chemical compounds, data analysis and reporting results and...

  • Senior Scientist

    3 weeks ago

    Boston, Massachusetts, United States Asimov Full time

    Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We're developing a mammalian synthetic biology platform––from cells to software––to enable the design and manufacture of next-generation therapeutics.We are seeking a Senior Scientist, Biologics Cell Line...

  • Sr. Scientist, Analytical Development

    1 month ago

    Boston, Massachusetts, United States Scorpion Therapeutics Full time

    Scorpion is a pioneering clinical-stage oncology company redefining the frontier of precision medicine to deliver optimized and transformational therapies for larger populations of patients with cancer. Scorpion has built a proprietary and fully integrated platform of the most advanced technologies across cancer biology, medicinal chemistry, and data...