Scientist II, Downstream Process Development

Found in: Resume Library US A2 - 1 week ago


Plainville Connecticut, United States Lifelancer Full time
What will you do?

Contribute to multiple projects and participate in the planning and execution of process development and scale up activities (both bench and pilot scale).

Serve as functional SME and work collaboratively with other team members on all aspects of downstream execution for viral vector processes.

Participate and/or lead the training and development of other team members.

Prepare and modify documents (development plans, batch records, SOPs, protocols, summary reports).

Identify technical gaps/facility fit challenges for new clients/processes

Support analytical testing for process development and characterization.

Lead Practical Process Improvement (PPI) initiatives

How will you get here?

Education

B.S. in Chemical Engineering, Biochemistry, Biology or related field with 3+ yrs, of experience or Masters degree.

Experience

Design and execution of downstream unit operations

Have understanding of experimental design and be able to independently execute laboratory experiments.

Strong hands-on experience with different purification techniques such as affinity and anion exchange chromatography and associated instrumentation such as AKTA chromatography systems and Unicorn software.

Experience with depth filtration design and sizing including manifold assemblies.

Design and execute DOE studies high-throughput screening for purification process improvements including parameter optimization, scale-up, and buffer selection.

Viral reduction filtration and support for viral clearance studies.

Has completed tangential flow filtration along with final formulation for virus, and plasmid DNA-based gene therapies.

Scale-up of downstream processes, supports process characterization and validation activities.

Effective problem solving and troubleshooting abilities.

Collaborating with Upstream and Analytical Testing/Development teams to build process understanding and design and execution of in-process testing and control assays

Knowledge, Skills, Abilities

Working level knowledge of downstream purification of mammalian and insect cell culture processes

Experience in scale up and scale down of purification processes.

Ability to analyze and summarize scientific data

Understanding of cGMP and regulatory requirements of biopharmaceutical manufacturing.

Strong interpersonal and communications skills; written and oral

Ability to function in a rapidly changing environment handle multiple priorities.

A flexible work schedule is required including Weekend and night as needed to support lab activities.

Please use the below link for job application and quicker response


  • Manager - Downstream Process Development

    Found in: Resume Library US A2 - 1 week ago


    Plainville, Connecticut, United States Lifelancer Full time

    Job Title: Manager - Downstream Process Development Location/Division Specific Information: US - Massachusetts Plainville How will you make an impact? In Viral Vector Service BioProcess Sciences, we develop, characterize and scale-up bioprocesses for robust manufacture of viral vectors to help our clients deliver lifesaving therapies to patients. As...

  • Associate Scientist

    Found in: Resume Library US A2 - 1 week ago


    Trumbull, Connecticut, United States Global Channel Management, Inc Full time

    Associate Scientist needs 1+ years experience Associate Scientist requires: Chemistry degree or Associates Degree with relevant industrial experience is required. Relevant formulating experience in consumer packaged goods will be taken into consideration. Advanced knowledge of detergents chemistry and ability to understand and carry out standard methods...

  • Engineer II

    Found in: Resume Library US A2 - 1 week ago


    Waterford, Connecticut, United States Solvenow Inc. Full time

    Job SummarySpecific duties include: Monitoring and trending of electrical system health Preparation of engineering technical evaluations Development of maintenance strategies and corrective action plans and supporting development of design change documentation. Perform other duties as requested or assigned The candidate will work in a broad range of...

  • Engineer II

    Found in: Resume Library US A2 - 1 week ago


    Waterford, Connecticut, United States Solvenow Inc. Full time

    Job SummaryThe individual shall have relevant welding experience per Section 7.0 of ANSI B5.16. Additional acceptable relevant welding experience includes welding, weld planning, preparing weld data records, preparing weld repair dispositions, designing welds, analyzing welds, inspecting welds, qualifying welding procedures and personnel, performing...

  • Certified Sterile Processing Tech

    Found in: Resume Library US A2 - 2 weeks ago


    Bridgeport, Connecticut, United States Yale New Haven Health Full time

    Overview: To be part of our organization, every employee should understand and share in the YNHHS Vision, support our Mission, and live our Values. These values - integrity, patient-centered, respect, accountability, and compassion - must guide what we do, as individuals and professionals, every day. At Bridgeport Hospital, we are committed to providing...

  • Process Engineer

    Found in: Resume Library US A2 - 1 week ago


    Danbury, Connecticut, United States Knowhirematch Full time

    Join a leading innovator in the production of high-purity GMP chemicals, where your expertise can shine and grow. We're looking for a dynamic Chemical Engineer to lead projects ranging from $50K to $1M, including site expansions, laboratory enhancements, equipment updates, and utility improvements. You'll dive into the heart of process engineering,...


  • Plainville, United States CareerBuilder Full time

    Description Job Schedule: Full Time Standard Hours: 40 Job Shift: Shift 1 Shift Details: Monday-Friday Work where every moment matters. Every day, over 30,000 Hartford HealthCare colleagues come to work with one thing in common: Pride in what we do, knowing every moment matters here. We invite you to become part of Connecticuts most comprehensive healthcare...

  • Process Improvement Engineer

    Found in: Resume Library US A2 - 1 day ago


    Groton, Connecticut, United States General Dynamics Electric Boat Full time

    Overview: The Process Engineering Organization provides mission-critical support to EB leadership by developing and managing the organization's improvement strategies, executing improvement initiatives, mentoring and supporting employees in executing improvement, and measuring the impact of an organization's improvement activities. These activities are...

  • Crystallization Scientist

    Found in: Resume Library US A2 - 1 week ago


    Groton, Connecticut, United States Eurofins USA PSS Insourcing Solutions Full time

    Job Description Support crystallization process development activities of the group through laboratory experiments including solubility screening experiments, kinetic solubility and metastable zone width measurements, and laboratory-scale crystallization experiments. Hands-on generation of solid-state characterization data using powder X-ray diffraction...

  • NDT Engineering Examiner

    Found in: Resume Library US A2 - 1 week ago


    Groton, Connecticut, United States General Dynamics Electric Boat Full time

    Overview: Phased-Array UT (PAUT) - NDT Engineering Level III Examiner / Senior / Specialist Location: Groton Shipyard / Groton, Connecticut   The successful candidate will join the Nondestructive Test (NDT) Engineering Services organization within Electric Boat (EB) and support Phased Array Ultrasonic Testing (PAUT) shipyard development and...

  • Analytical Chemist

    Found in: Jooble US O C2 - 18 hours ago


    Connecticut, United States Joulé Full time

    Job Title: Analytical Chemist Location: Groton, CT Type: Contract Join the worlds premiere biopharmaceutical company, working towards revolutionary medicines that enables to enrich and extend life for people suffering from all types of diseases. Responsibilities Work directly with Pfizer senior scientist in day-to-day tasks. Conduct sample preparation and...

  • Process Metallurgist

    Found in: Resume Library US A2 - 1 week ago


    North Haven, Connecticut, United States Ulbrich Stainless Steels & Special Metals, Inc. Full time

    Job Description We are currently seeking a Process Metallurgist to become part of the Ulbrich Shaped Wire team located in North Haven, CT. The Process Metallurgist will support sales, production, and other organizational units in the determination of the organization’s capacity to produce products that achieve defined customer requirements.  Consult with...

  • Sterile Processing Tech 1

    Found in: Resume Library US A2 - 5 days ago


    East New London, Connecticut, United States Yale New Haven Health Full time

    Overview: To be part of our organization, every employee should understand and share in the YNHHS Vision, support our Mission, and live our Values. These values - integrity, patient-centered, respect, accountability, and compassion - must guide what we do, as individuals and professionals, every day. Performs A Variety Of Tasks Related To Cleaning,...

  • Program Representative

    Found in: Resume Library US A2 - 1 week ago


    Groton, Connecticut, United States General Dynamics Electric Boat Full time

    Overview: General Dynamics Electric Boat is seeking a Program Representative to oversee the development of Ship Alterations (ShipAlts) to submarine components and systems. The candidate will be responsible to obtain tasking through Task Instructions with NAVSEA; coordinate efficient and effective communication between all internal and external stakeholders...

  • Mechanical Engineer I

    Found in: Resume Library US A2 - 5 days ago


    Groton, Connecticut, United States General Dynamics Electric Boat Full time

    Overview: Electric Boat Nondestructive Test (NDT) Engineering is seeking a motivated individual to join its NDT New Technologies Team. The NDT Engineering New Technologies Team leads research & development (R&D) efforts to test and implement emerging NDT methods (e.g. Phased-Array Ultrasonic Testing, Computed Radiography, etc.) for use in Electric Boat’s...

  • Quantitative Researcher

    Found in: Resume Library US A2 - 1 week ago


    Stamford, Connecticut, United States Trexquant Investment Full time

    Trexquant is a systematic hedge fund where we use thousands of statistical algorithms to trade equity, futures and other markets globally. Starting with many data sets, we develop large sets of features and use various machine learning methods to discover trading signals and effectively combine them into market-neutral portfolios. We are looking for data...

  • Quantitative Researcher

    Found in: Resume Library US A2 - 1 week ago


    Stamford, Connecticut, United States Trexquant Investment Full time

    Trexquant is a systematic hedge fund where we use thousands of statistical algorithms to trade equity, futures and other markets globally. Starting with many data sets, we develop large sets of features and use various machine learning methods to discover trading signals and effectively combine them into market-neutral portfolios. We are looking for data...

  • Tower Technician

    1 week ago


    Plainville, United States Aerus Solutions Full time

    Job DescriptionJob DescriptionBenefits:401(k) matchingCompetitive salaryDental insuranceHealth insuranceOpportunity for advancementPaid time offTraining & developmentTower TechnicianAre you a tech-savvy adventurer with a passion for heights and cutting-edge technology? We're seeking enthusiastic Tower Technicians to join our dynamic team and play a...

  • Tower Technician

    1 week ago


    Plainville, United States Aerus Solutions Full time

    Job DescriptionJob DescriptionBenefits:401(k) matchingCompetitive salaryDental insuranceHealth insuranceOpportunity for advancementPaid time offTraining & developmentTower TechnicianAre you a tech-savvy adventurer with a passion for heights and cutting-edge technology? We're seeking enthusiastic Tower Technicians to join our dynamic team and play a...

  • Tower Technician

    17 hours ago


    Plainville, United States Aerus Solutions Full time

    Job DescriptionJob DescriptionBenefits:401(k) matchingCompetitive salaryDental insuranceHealth insuranceOpportunity for advancementPaid time offTraining & developmentTower TechnicianAre you a tech-savvy adventurer with a passion for heights and cutting-edge technology? We're seeking enthusiastic Tower Technicians to join our dynamic team and play a...