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Mass Spectrometry Research Scientist
2 months ago
Vicinitas Therapeutics is a pioneering biotechnology firm dedicated to the advancement of targeted protein stabilizers, specifically Deubiquitinase Targeting Chimeras (DUBTACs). Our mission is to leverage this innovative technology to address significant challenges in human health by creating next-generation therapies for a class of disease-causing proteins that have been previously difficult to target. Originating from a collaboration between Novartis Institutes for BioMedical Research and the University of California, Berkeley, Vicinitas Therapeutics operates from South San Francisco, California.
The Chemical Biology division plays a crucial role in the identification and development of DUBTACs through the implementation of state-of-the-art mass spectrometry (MS) platforms. We are currently seeking a Mass Spectrometry Scientist to manage existing platforms and innovate new methodologies to facilitate the identification and validation of DUB recruiters and DUBTACs. The ideal candidate will be a collaborative, inquisitive, and adaptable team member who thrives on problem-solving and working closely with colleagues to advance our research goals.
Key Responsibilities
- Design and conduct cell-based screening experiments for proteomics investigations.
- Plan and implement MS-based experiments aimed at elucidating the mechanism of action (MOA) of DUBTACs.
- Collaborate with junior scientists within the Chemical Biology team, providing mentorship in the conceptualization and execution of mass spectrometry experiments.
- Engage with data analysis, protein sciences, and medicinal chemistry teams to ensure alignment with corporate objectives.
Qualifications
- PhD in Biochemistry, Analytical Chemistry, Chemistry, or a related discipline.
- 2-8 years of experience with high-resolution mass spectrometry instruments and techniques in proteomics analysis, with a strong background in operating, maintaining, and troubleshooting equipment, preferably on ThermoFisher or Bruker platforms.
- Proven ability to utilize and implement various software tools for MS data analysis, with experience in developing automated pipelines for data processing being advantageous.
- Experience in creating custom methodologies for sample preparation and MS analysis to meet project objectives.
- Strong communication skills, demonstrating leadership by example and the ability to adapt to dynamic conditions to consistently achieve scientific goals.
Compensation and Benefits
Expected Salary Range: Scientist I $120,000-$130,000 / Scientist II $130,000-$145,000. (Compensation and leveling will be commensurate with experience and expertise and could fall outside of the stated range)
In addition to competitive salaries, Vicinitas offers a comprehensive benefits package, including:
- Annual Bonuses
- Early-stage Equity
- Four Medical Plan Options
- Dental & Vision Coverage
- Short Term and Long-Term Disability
- Group Term Life Insurance
- FSA Plans (medical, dependent daycare, and commuter accounts)
- 401k Plan
- Generous Annual Holiday Schedule
- Unlimited Flexible Time Off
- Annual Year-end Shut Down
Vicinitas is committed to providing equal employment opportunities (EEO) to all employees and applicants without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics, or any other characteristic protected by applicable federal, state, or local law.
