Senior Research Scientist

1 week ago

San Diego, California, United States WuXi AppTec Full time
Job Title: Principal Scientist

WuXi AppTec is seeking a highly motivated and skilled Principal Scientist to lead our fast-growing bioanalysis platform. The successful candidate will be responsible for designing, executing, troubleshooting, and delivering projects with LCMS, including small molecules and biologics, as well as lipidomics, glycomics, and proteomics.

Key Responsibilities:
  • Provide overall scientific and operational support for the bioanalysis group.
  • Contribute and apply expertise and knowledge to collaborate with partners in the design and execution of related studies.
  • Work with business management and development team for sponsor engagement and project proposal preparation.
  • Lead multiple ongoing projects to meet expected timelines.
  • Responsible for new capability implementation and team building.
  • Contribute to the overall operations and to the achievement of departmental goals.
  • Communicate with clients for designing, analysis, reporting, and recording activities.
  • Perform job-specific tasks in compliance with applicable Regulations, International Standards, WuXi AppTec Policies, and Standard Operating Procedures.
  • Hands-on bench work when necessary.
Requirements:
  • PhD with 6-10 years of hands-on experience in Proteomics, Mass Spectrometry, and/or related field.
  • Industry experience from CRO is a plus; strong scientific knowledge and technical skills in the bioanalytic field are desired.
  • Expert-level skills in the following areas are required:
    • Solid understanding of qualitative and quantitative LCMS workflows in small molecule, lipidomics, glycomics, and proteomics with associated sample preparation techniques.
    • Solid competency in a broad range of LCMS instrumentation such as QQQ, QTOF, and orbitrap and application solutions.
    • Experience with sample preparation from tissues, cells, and biofluids as needed to enable quantitative workflows for drug discovery programs.
    • Experience in protein characterization, peptide mapping, PTM analysis (phosphorylation and ubiquitination), and targeted proteomics.
    • Experience with MaxQuant, Skyline, and Tracefinder, Protein Pilot, Proteome Discoverer.
    • Must be able to maintain UPLC/Mass spec for routine operations.
    • Prior in vitro assays and in vivo pharmacology experience is a big plus.
  • Demonstrated time management and multi-tasking skills, ability to effectively prioritize workload and manage changes in direction.
  • Demonstrated ability to lead and manage other scientists and associates.
  • Demonstrated ability for attention to details and concern for impact.
  • Effective communication skills with the ability to give and receive feedback, both verbally and in writing.
  • Ability to work in a team environment and independently as required.
  • Ability to work in a fast-paced environment.
  • Well-organized and adaptable to change.
  • Computer skills: knowledge of internet research, MS Word, Excel, Outlook, and PowerPoint. Ability to learn instrument and data analysis software.

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