Scientist Consultant, Antibody Discovery
7 days ago
We are seeking a highly motivated and experienced Scientist Consultant, Antibody Discovery to join our growing team at Net2Source Inc. in South San Francisco, CA.
Job Summary:The successful candidate will be responsible for designing and executing antibody discovery campaigns for therapeutic and reagent antibodies using phage display. This includes generating antibody fragment libraries, performing HT binding screens, and sequencing analysis to generate hits. The ideal candidate will have a strong background in molecular biology, antibody and protein expression, and biophysical characterization of recombinant antibodies and proteins.
Key Responsibilities:- Design strategies and execute antibody discovery campaigns for therapeutic and reagent antibodies using phage display
- Generate antibody fragment libraries for antibody discovery and engineering, perform HT binding screens (ELISA and multi-plex flow cytometry) and sequence analysis to generate hits
- Rank-order clones by affinity, in vitro potency, and early developability assessment
- Execute sequence optimization of lead antibodies to improve developability and binding affinity
- Design and clone constructs for mAbs, bispecific, and multi-specific antibodies for recombinant antibody production
- Support NGS-based antibody discovery workflow
- Present data and updates to management and project teams
- Follow good documentation practice including maintaining good record keeping in Electronic Notebooks
- PhD in Biochemistry, Biomedical/Chemical Engineering, Immunology, or related field with minimum of 2 years of post-graduate experience (preferably in industry), MS with 8+ years of research experience, BS with 10+ years of research experience in antibody or protein engineering
- Significant experience in antibody discovery and protein engineering by using single B cell cloning, hybridoma, or phage/yeast display techniques
- Strong background in molecular biology, antibody and protein expression, and biophysical characterization of recombinant antibodies and proteins
- Demonstrated experience in working collaboratively across various scientific disciplines and other parts of the organization to meet end goals
- Highly motivated individual with exceptionally good organizational skills, and attention to details
- Demonstrate ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
- Excellent written and verbal communication skills
- Strong interpersonal skills
- Experience in single domain antibodies, multi-specific antibody engineering, Fc engineering, antibody drug conjugates, naïve phage or yeast display library design
- Experience in NGS analysis for antibody discovery and engineering
- Significant contributions to successful biologics drug discovery programs in biotech/biopharma industry
We offer a competitive salary and benefits package, as well as opportunities for professional growth and development. If you are a motivated and experienced professional looking for a new challenge, please submit your application.
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