Research Associate, Clinical Lab

3 weeks ago

Palo Alto, California, United States Delfi Diagnostics Inc. Full time

About the Role
In this laboratory position, you will be responsible for managing a biorepository to support DELFI's development and validation studies, tracking and executing maintenance of laboratory equipment, and executing laboratory studies intended to validate NGS-based laboratory tests for cancer detection. You will be part of a cross-functional team working to launch regulated products for clinical use.

About Us
DELFI Diagnostics, Inc. (DELFI Diagnostics) is developing next-generation, blood-based tests that are reliable, accessible and deliver a new way to help detect cancer. Employing advanced machine-learning methods to whole-genome sequencing data, the DELFI platform is built to address the highest-burden health challenges. DELFI Diagnostics prioritizes solutions that have the potential to save lives on a global scale, including for historically underserved populations. DELFI Diagnostics' platform relies on fragmentomics – the discovery that cancer cells are more chaotic than normal cells and, when they die, leave behind tell-tale patterns and characteristics of cell-free DNA (cfDNA) fragments. FirstLook Lung, for individuals eligible for lung cancer screening, is DELFI Diagnostics' first laboratory-developed screening test and can be part of routine blood work. FirstLook Lung uses millions of data points to reliably identify individuals who may have cancer detected through low-dose CT, including early stage disease with a negative predictive value of 99.7 percent. This test has not yet been cleared or approved by the FDA.

Our Values
We are guided by our core values: Lead with Science, Anchor in Pragmatism, Build With & For All, and Put We over I. These values drive our pursuit of radically improving health outcomes and our commitment to serving humanity. We pioneer life-changing science by ensuring quality, transparency, and rigor at all times. We explore thoughtfully, experiment smartly, and deliver impact with conviction. We are a home for high-performing people who build collective intelligence through teamwork. We show up with empathy, humility, and integrity at every step of the journey.

Key Responsibilities
Manage a biorepository containing plasma and intermediate assay products, ensuring that samples are maintained in accordance with stability requirements and are organized to enable efficient sample pulls. Organize, aliquot and prepare samples for shipment or internal laboratory studies. Maintain a schedule for equipment maintenance and calibration, and execute on required activities personally or through vendors. Contribute to high-quality laboratory test development by performing development, design verification, and design validation activities in the NGS Laboratory. Mitigate potential safety concerns/harms by supporting risk management activities, including risk evaluation and implementation of control measures.

What You'll Accomplish
Achieve a level of organization in biorepository management that enables quick identification and pull of samples at any time. Become an expert operator of DELFI's NGS laboratory process. Consistently maintain departmental laboratory equipment on the required schedule.

What You'll Bring
Bachelor's degree in a relevant field (e.g., biomedical engineering, molecular biology, genetics, or genomics). Experience with biorepository management. Experience with general biology laboratory equipment and techniques. Ability to master use of software systems for laboratory management. Diligence in implementing systems for laboratory management. Skills in technical and non-technical communication. Ability to master new concepts and skills quickly, with strong attention to detail. Preferred experience with automated liquid handling systems and direct experience in a regulated environment (CLIA, CAP, NYS, FDA, GXP, etc.).

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