Staff Research Associate, Molecular Engineering

1 month ago

Palo Alto, California, United States Arc Institute Full time
About the Position

We are seeking a highly skilled and motivated Staff Research Associate to join the Molecular Engineering team at Arc Institute. The successful candidate will play a critical role in the development, optimization, and automation of critical platform capabilities, including high throughput cloning, molecular biology, and virus production for mammalian cell engineering.

This is an excellent opportunity for a highly motivated and curious researcher interested in helping convert cutting-edge and novel molecular technologies into reproducible and robust tools for genetic perturbation.

About You

You love science and learning. Whether it's gaining knowledge in new fields of scientific research or learning a new lab technique, you never stop being curious and routinely enjoy stepping out of your comfort zone to learn new things.

You are flexible and adaptable, eager to try new ways of tackling problems beyond the approaches with which you're familiar while also bringing energy and curiosity to the optimization of existing approaches.

You have a creative and curious spirit, open and eager to try new ways of tackling problems beyond the approaches with which you're familiar.

Responsibilities

Develop and optimize scalable workflows for executing on Arc's Alzheimer's Disease Initiative (high throughput cloning, lentiviral production, and cell line engineering) and other technology development projects (novel effector systems, multiplexed perturbations, new delivery technologies).

Build a center of excellence (plasmids, mRNA, virus, LNPs, etc.) to enable arrayed genetic perturbations in hPSC-derived cells.

Utilize a wide array of high-throughput molecular biology techniques, such as Gibson and Golden gate assembly, DNA/RNA isolation, cDNA synthesis, qPCR, ddPCR, and more.

Conduct mammalian cell culture and transfection-based experiments, including flow cytometry readouts.

Leverage automation to help execute, streamline, optimize, and track molecular biology workflows.

Help organize materials and reagents with detailed tracking in our LIMS system.

Collaborate with cross-functional teams at Arc.

Analyze and present data at internal meetings and seminars.

Execute tasks and experiments with a focus on efficiency and reproducibility.

Requirements

BS/MS or equivalent professional experience in Biology, Biotechnology, Genetics, Cellular Biology, or relevant fields.

With a BS degree, 7+ years of technically relevant experience or with an MS degree, 5+ years of relevant postgraduate experience.

Industry experience is desirable but not required.

Relevant lab experience including demonstrated and proficient skills in high throughput cloning, molecular biology, virus production, and mammalian cell engineering.

Detail-oriented with excellent organizational and time management skills.

Strong oral and written communication skills.

Ability to multitask, willingness to learn, and work in a highly collaborative environment.

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