Senior Biotechnology Research Scientist

1 week ago


San Diego, California, United States Novartis Farmacéutica Full time
About the Role

We are seeking a highly skilled and experienced Senior Biotechnology Research Scientist to join our Cell and Gene Therapy team at Novartis Farmacéutica. As a key member of our team, you will play a critical role in the development of innovative medicines for patients with devastating diseases.

Key Responsibilities
  • Lead and contribute to the development of next-generation cell and gene therapy delivery systems, improving pipeline and platform advances and novel therapeutic capabilities.
  • Develop and lead efforts to create more potent, safer, and tolerable lentiviral vector (LVV) and adeno-associated virus (AAV) vectors, focusing on improving tropism, reducing immune response, and enhancing spatial/temporal regulated expression control strategies.
  • Enable translation from in vitro/in vivo mouse and nonhuman primate proof-of-concept studies to therapeutic disease programs for preclinical development.
  • Initiate, lead, and contribute to interdisciplinary research programs in a highly collaborative and matrixed manner across internal groups and with external partners.
  • Prepare reports, manuscripts, and protocols, adhering to good research practices and quality culture across NIBR.
  • Present results at internal and external meetings and conferences.
Requirements
  • Bachelor's degree in cell and gene therapy, bioinformatics, molecular/cell biology, bioengineering, or related scientific field with 12 years of industry experience or Master's degree with 10 years of industry experience or PhD with 6 years of industry experience.
  • Successful track-record in leading scientists and project team members with diverse backgrounds.
  • Demonstrated expertise in LVV and AAV biology, virology, viral tropism engineering, transcriptional and post-transcriptional mechanisms, and analytical/process development for LVV/AAV production.
  • Ability to work collaboratively across a dynamic and collaborative scientific and development environment.
  • Strong publication, patent, and/or external presentation record.
  • Genetic/epigenomic/transcriptomic profiling technologies, genome engineering (e.g. CRISPR), nonviral gene therapy, sh/miRNA biology, and/or analytical/process development for LVV/AAV production are highly desired.
Why Novartis Farmacéutica

We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.



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