Senior Scientist, Human Genetics Expert

4 days ago

MA United States Takeda Pharmaceutical Full time
About the Role

Takeda Pharmaceutical is seeking a highly skilled Senior Scientist, Human Genetics to join our team in Cambridge, Massachusetts. As a key member of our Human Genetics team, you will play a critical role in advancing our pipeline across Gastrointestinal & Inflammatory diseases, Neurosciences, and Oncology.

Key Responsibilities:

  • Lead human genetics projects from ideation to execution, using publicly available and proprietary data, to advance target identification and validation, safety assessment, and patient stratification.
  • Contribute to establishing the Human Genetics group strategy and collaborate with colleagues in various functions across the organization to drive impact and contribute to go-no-go decisions across Takeda's drug discovery and development pipeline.
  • Collaborate with disease area leads to identify priorities and design human genetic analyses.

Requirements:

  • PhD in computational biology, bioinformatics, or a similar discipline with 2+ years of postdoctoral experience in human genetics research.
  • Deep experience with GWAS/eQTL/pQTL analyses, fine-mapping and colocalization, Mendelian randomization, WES/WGS sequencing data analyses, and rare variants statistical analyses required.
  • Track record experience analyzing genetic data linked to longitudinal real-world health data from large biobanks (e.g. UK Biobank, FINNGEN, Genes and Health, All Of Us, Million Veterans Project etc) required.
  • Experience contributing to pre-competitive academic-pharma partnerships preferred.
  • Experience with proteomics (e.g Olink) and/or transcriptomic data analyses desired.
  • Experience with phenotype ontologies, pathway-based approaches, multivariate analyses, polygenic risk score analyses, machine learning desired.
  • Strong scientific understanding of molecular biology and genomics, and ability to interpret genetic findings in disease context.
  • Familiarity with pharmaceutical R&D processes and one or more diseases areas of interest of Takeda (neuroscience, gastrointestinal and inflammation) desired.
  • Excellent communication, presentation, and interpersonal skills.
  • Independent, highly collaborative with ability to work in cross-functional and diverse team environment.
  • Solid knowledge of Unix, command lines interfaces, and fluency in common scripting and/or programming language (e.g. R, Python, Perl, Java, C/C++).
  • Solid experience with parallel computing and cloud computing required.

What We Offer:

  • Competitive salary and benefits package.
  • Opportunity to work with a world-class R&D organization.
  • Collaborative and inclusive work environment.
  • Professional development opportunities.

Location:

Cambridge, MA, USA (hybrid)

EEO Statement:

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state, and local laws, and any other characteristic protected by law.

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