Senior Medicinal Chemist

17 hours ago


La Jolla, California, United States Allen Spolden Full time
Job Title: Director or Associate Director, Medicinal Chemistry

We are seeking an experienced and innovative medicinal chemist to lead our medicinal chemistry team. The ideal candidate will have a proven track record of success in drug discovery and a strong ability to integrate multiple R&D disciplines into a successful strategic project plan.

Key Responsibilities:
  • Lead a team of medicinal chemists and drive molecular discovery efforts to deliver development and clinical candidates.
  • Develop and implement strategies to identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis-driven design principles.
  • Collaborate closely with molecular and cellular biology, pharmacology, computational chemistry, ADME, and other key functions.
  • Act as liaison between Entos, CROs, and other external partners.
  • Influence the prospective use of computational methods and leverage automated synthesis and high-throughput experimentation capabilities.
  • Work closely with AI/ML teams to develop and implement relevant predictive models to aid in the design of new molecules.
  • Communicate project updates clearly and effectively to the broader team and key stakeholders.
  • Work as a senior member of the Chemistry research group and foster a culture of scientific excellence, innovation, and teamwork.
Preferred Qualifications:
  • A Ph.D./Postdoc in organic chemistry with 8 or more years of experience in Pharma/Bio-tech drug discovery.
  • Expert in modern synthetic organic chemistry approaches and principles demonstrated through publications in journals and patents.
  • Ability to integrate multiple R&D disciplines into a successful strategic project plan.
  • Experience in leading projects and driving programs through the preclinical development process.
  • Experience working with computational chemists as part of project team in design of drug targets is required.
  • Strong interpersonal, communication, time management, and leadership skills.
  • Experience mentoring or leading junior chemists.
  • Creative problem-solving and management of relationships with several stakeholders within and beyond the company.
Benefits:
  • Dental, Medical, Vision, and 401K.


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