Senior Scientist-Method Development-Large Molecule Bioanalysis Specialist

3 weeks ago


Exton, Pennsylvania, United States Frontage Laboratories Full time

Job Summary:

The Senior Method Development Scientist plays a key role in supporting method development for large molecules using LC-MS/MS platforms. This position requires a strong background in analytical chemistry, biochemistry, or a related field, with a focus on bioanalytical method development for large molecules.

Key Responsibilities:

  • Develop and optimize methods for large molecule quantitation in biological matrices using LC-MS/MS platforms.
  • Collaborate with the method validation team to ensure seamless method transfer and validation.
  • Communicate project timelines, status, and data to stakeholders, addressing any issues that may arise.
  • Research and identify new techniques and procedures to strengthen Frontage Laboratories' capabilities.
  • Maintain regulatory compliance, ensuring GLP regulations and SOPs are followed in all bioanalytical service activities.
  • Train and mentor junior scientific staff, promoting knowledge sharing and growth.
  • Operate and maintain complex instrumentation, adhering to safety protocols.

Requirements:

  • Ph.D. or Master's degree in Analytical Chemistry, Biochemistry, Biology, or a related scientific discipline.
  • 6-10 years of direct experience in bioanalytical method development for large molecules using LC-MS/MS in the biotech, pharma, or CRO industry.
  • Demonstrated expertise in mass-spectrometry method development for antibodies, including LC-MS intact protein analysis, peptide mapping, and conjugate analysis.
  • Experience with oligonucleotides and liposomal drug quantitation using LC-MS/MS is a plus.
  • Proven ability to work effectively in a team environment, with excellent oral and written communication skills.
  • Strong knowledge of GLP and ability to train technical personnel.
  • Efficient time management, strong troubleshooting, and analytical skills.
  • Detail-oriented and meticulous, with the ability to work independently under time constraints.

Benefits:

  • Frontage Laboratories offers a competitive compensation package, including health and dental insurance, a 401(k) plan, health insurance, short and long-term disability insurance, and life insurance.

Equal Opportunity Employer:

Frontage Laboratories is an equal opportunity employer, committed to diversity and inclusion. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, or status as a protected veteran or qualified individual with a disability.



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