Senior Scientist

1 month ago

Exton, Pennsylvania, United States Frontage Laboratories Full time
Job Summary

The Senior Method Development Scientist supports method development using LC-MS/MS platform for large molecules (biomarkers, proteins, antibodies, ADCs, Oligonucleotides, etc). This role involves serving as a subject matter expert when new proposals are received, reviewing client requests, and evaluating project feasibility. The successful candidate will develop methods after contract signing, transfer developed methods to the validation team, and troubleshoot challenging methods.

Key Responsibilities
  • Develop methods using LC-MS/MS platform for large molecule quantitation in biological matrices.
  • Facilitate method transfer from the Method Development team to the Validation team.
  • Communicate project timelines, status, and data to Principal Investigators, addressing any issues that may arise.
  • Ability to work on multiple projects simultaneously.
  • Research literature and external sources to identify new techniques and procedures that strengthen Frontage's capabilities.
  • Maintain regulatory compliance, ensuring GLP regulations and SOPs are followed in all bioanalytical service activities.
  • Assist with training and/or mentoring of junior scientific staff.
  • Set up, utilize, and maintain complex instrumentation, following safety precautions.
Requirements
  • Ph.D. or Master's degree in Analytical Chemistry, Biochemistry, Biology, or a related scientific discipline.
  • 6-10 years of direct experience in bioanalytical method development for large molecules using LC-MS/MS in the biotech, pharma, or CRO industry.
  • Demonstrated experience in mass-spectrometry method development for antibodies, including LC-MS intact protein analysis, peptide mapping, conjugate analysis, etc.
  • Demonstrated experience in small molecule and protein mass-spectrometry of quantitation of antibody drug-conjugates (ADC), including total Antibody, Conjugated payload, and free payload.
  • Experience with Oligonucleotides and liposomal drug quantitation using LC-MS/MS is a plus.
  • Proven ability to work in a team environment, with excellent oral and written communication skills.
  • Good knowledge and application of GLP, with the ability to train technical personnel.
  • Efficient time management.
  • Strong troubleshooting and analytical skills.
  • Detail-oriented and meticulous.
  • Ability to work independently under time constraints.
Benefits

Frontage Laboratories offers a competitive compensation and benefits package, including health and dental insurance, a 401(k) plan, disability insurance, and life insurance.

Frontage Laboratories is an equal opportunity employer, committed to diversity and inclusion. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, or disability status.

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