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Senior Research Associate, Assay Technology Lead
2 months ago
We are seeking an experienced Research Associate/Senior Research Associate to join our Discovery Sciences team at Planet Pharma. As a key member of our team, you will play a critical role in accelerating our search for new oncology therapeutics.
Key Responsibilities- Design and execute lead discovery screening methods and experiments to identify compound hits and advance them through hit-to-lead and lead optimization stages.
- Collaborate with cross-functional teams to develop and implement biochemical and biophysical assays for hit identification and lead optimization, evaluating compound potency, selectivity, and mechanism of action.
- Develop, characterize, and execute novel biochemical and biophysical assays to support screening and preclinical development.
- Communicate scientific progress effectively to the Discovery Sciences team and facilitate project execution within established timelines.
- Generate, manage, evaluate, and maintain critical data in an organized manner and disseminate data broadly to relevant departments.
- Bachelor's degree with 3-5 years of experience or Master's degree with 2-3 years of experience in biochemistry, biophysics, biotechnology, or related field.
- Hands-on protein biochemistry experience (e.g., characterizing and analyzing protein-ligand or protein-protein interactions).
- Experience with biochemical/biophysical assay development, validation, and troubleshooting.
- Proficiency in execution of in vitro biochemical and biophysical assays suitable for the discovery, validation, or mechanistic characterization of target molecules (ITC, SPR/BLI, TR-FRET, fluorescence polarization, etc.).
- Familiarity with data processing and visualization tools for data analysis and figure generation (e.g., R, Vortex, GraphPad Prism, Genedata Screener, etc.).
- Attention to detail with excellent organizational, experimental data recording, and time management skills.
- Excellent written and verbal communication skills.
- Innovative and flexible team-player with high energy and a demonstrated willingness to learn in a fast-paced environment.
- Familiarity with automated liquid handling (SPT Dragonfly and/or Mosquito, Agilent Bravo, Tecan).
- Experience with high throughput screening.
- Facile with instrumentation, able to trouble shoot problems and work with engineers to generate successful solutions to technical limitations.
- Rigorous, quantitative, detail-oriented experimentalist with an understanding of statistics.
