Senior Computational Biologist

3 weeks ago


San Francisco, California, United States BayOne Solutions Full time
{"title": "Computational Scientist", "description": "Role: Computational Scientist

Location: South San Francisco, CA

Duration: 12+ Months Contract

A Hybrid role

Key Responsibilities:

  • Collaborate with scientists in Oncology to analyze large-scale single-cell and bulk RNA, TCR, ADT, and ATAC-seq datasets to address scientific hypotheses and deliver novel insights.
  • Develop analytical approaches to integrate and interpret these data, delivering insights into disease biology and mechanisms of action to propel our pipeline and clinical research goals.
  • Coordinate the processing and standardization of newly incoming datasets to make them analysis-ready.
  • Document code, analysis processes, and findings, including standardization of analytical workflows.
  • Present findings to the Cancer Immunogenomics group and Oncology collaborators.

Requirements:

  • Extensive experience in large-scale single-cell data analysis (RNA, TCR, ADT, ATAC), including gold-standard methods and novel, advanced analytical techniques such as:
  • ○ Multimodal data integration methods
  • ○ Cell phenotyping approaches, including topic modeling
  • ○ Clonotype analysis
  • ○ TCR-sequence analysis

Preferred Qualifications:

  • Expertise in (immuno)-oncology, innate immunity, and/or T cell biology.
  • PhD (or Master's with significant experience) in Computational Biology, Bioinformatics, or a related field.
  • Proficiency in R, Python, and shell scripting.
  • Experience working with Git and high-performance computing.
  • High self-motivation and commitment to delivering high-quality results.
  • Ability to produce high-quality analysis results with minimal supervision, including meeting key deadlines and making sensible independent decisions.
  • Excellent communication skills and experience working as part of a team.
  • Curiosity and desire to learn more about computational biology and immuno-oncology biology.
"}

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