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Mass Spectrometry Research Scientist

2 months ago


South San Francisco, California, United States Vicinitas Therapeutics Full time
Position Overview

Vicinitas Therapeutics is a pioneering biotechnology firm dedicated to the advancement of targeted protein stabilizers, specifically Deubiquitinase Targeting Chimeras (DUBTACs). Our mission is to leverage this innovative technology to address significant challenges in human health by creating next-generation therapies aimed at a class of disease-causing proteins that have previously been difficult to target.

Our Chemical Biology team plays a crucial role in the identification and development of DUBTACs through the establishment of state-of-the-art mass spectrometry (MS) platforms. We are currently seeking a Mass Spectrometry Scientist to manage existing platforms and innovate new methodologies to facilitate the identification and validation of DUB recruiters and DUBTACs. The ideal candidate will be a collaborative, inquisitive, and adaptable team member who thrives on problem-solving and teamwork to advance our research goals.

Key Responsibilities

  • Design and implement cell-based screening experiments for proteomics analysis.
  • Plan and conduct MS-based experiments to elucidate the mechanism of action (MOA) of DUBTACs.
  • Mentor junior scientists within the Chemical Biology team and assist in conceptualizing and executing mass spectrometry experiments.
  • Collaborate with data analysis, protein sciences, and medicinal chemistry teams to achieve corporate objectives.

Qualifications

  • PhD in Biochemistry, Analytical Chemistry, Chemistry, or a related discipline.
  • 2-8 years of experience with high-resolution mass spectrometry instruments and techniques in proteomics. Proficiency in operating, maintaining, and troubleshooting instruments, particularly ThermoFisher or Bruker platforms, is preferred.
  • Proven ability to utilize various software tools for MS data analysis. Experience in developing automated pipelines for MS data processing and analysis is advantageous.
  • Experience in creating custom methods for sample preparation and MS analysis to meet project objectives.
  • Strong communication skills with a demonstrated ability to lead by example and adapt to evolving conditions to consistently achieve scientific goals.

Compensation and Benefits

Expected Salary Range: Scientist I $120,000-$130,000 / Scientist II $130,000-$145,000. (Compensation and leveling will be commensurate with experience and expertise and could fall outside of the stated range)

In addition to competitive salaries, Vicinitas offers a comprehensive benefits package that includes:

  • Annual Bonuses
  • Early-stage Equity
  • Four Medical Plan Options
  • Dental & Vision Coverage
  • Short Term and Long-Term Disability
  • Group Term Life Insurance
  • FSA Plans (medical, dependent daycare, and commuter accounts)
  • 401k Plan
  • Generous Annual Holiday Schedule
  • Unlimited Flexible Time Off
  • Annual Year-end Shut Down

Vicinitas is committed to providing equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics, or any other characteristic protected by applicable federal, state, or local law.