Pharmacometrician Associate Director
6 days ago
Revolution Medicines is a clinical-stage precision oncology company dedicated to developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. Our research and development pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies.
The OpportunityWe are seeking a passionate and energetic individual with strong PKPD modeling background to be part of the Nonclinical Development and Clinical Pharmacology (NDCP) Organization. As a PKPD modeler to support the pharmacometrics functions in the department, you will:
- Establish population PK models to identify intrinsic and extrinsic factors that impact PK, and to guide dose/schedule optimization and recommended phase 2 dose/schedule (RP2Ds) selection.
- Perform model-based simulations to optimize dosing to inform trial designs and clinical outcomes. Ensure quality and integrity of modeling and simulation results.
- Author and provide technical input for regulatory documents and submissions related to all aspects of pharmacometrics (including protocol, IB, briefing package, etc) and responses to regulatory questions.
- Engage and work with consultants and/or CROs on pharmacometrics activities to complement in-house knowledge/expertise and capacities.
A Ph.D. or Pharm.D. with 5+ years of experience in PKPD Modeling & Simulation. Extensive hands-on experience using NONMEM modeling software is a must. Familiar with common PKPD/TGI models and able to write customized NONMEM models. At least two years of relevant work experience in pharmaceutical companies. Proficiency in R programming is desired. Able to take dynamically assigned pharmacometrics tasks and deliver the results in a timely manner. Excellent verbal and written communication skills, and ability to clearly convey complex concepts and findings to both non-specialist and specialist audiences.
Preferred SkillsHave prior knowledge or familiarity with longitudinal model analysis (e.g. ctDNA and tumor shrinkage). Have prior knowledge or familiarity with ER analysis for oncology compounds. Familiar with data handling.
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