Principal Scientist, Structural Biology
4 weeks ago
About the Role
We are seeking a highly motivated and experienced Principal Scientist to join our team at GSK LLP. As a Principal Scientist, you will be responsible for leading research projects in structural biology, protein crystallography, and biophysics to support the development of vaccines and medicines.
Key Responsibilities
- Design and conduct complex experiments to determine the three-dimensional structures of proteins and protein complexes using techniques such as X-ray crystallography and cryo-electron microscopy.
- Collaborate with cross-functional teams to develop and implement new methods and protocols related to structural biology and protein chemistry.
- Interpret results of structural and biophysical experiments to inform structure-based drug design and vaccine development.
- Manage and maintain state-of-the-art laboratory equipment and ensure compliance with safety procedures and regulations.
- Author and present research findings and updates in internal reports, project meetings, and external scientific meetings.
Requirements
- PhD in a structural biology related field with a focus on protein crystallography.
- Three or more years of experience with protein chemistry and structural biology.
- Ability to design and conduct complex experiments and interpret results.
- Three or more years of experience in macromolecular crystallography, including the principles and techniques used in the field.
- Three or more years of laboratory experience in protein expression, biochemistry, protein crystallization, and data collection.
- Three or more years of experience using and maintaining crystallography equipment.
- Three or more years of experience using crystallography software tools for data processing, structure solution, refinement, and analysis.
Preferred Qualifications
- Post-Doctoral or industrial research experience in protein biochemistry, macromolecular crystallography, molecular modelling, molecular biology, computational biology, or other related discipline.
- Experience with other macromolecular structural determination methods such as cryo-EM, small-, medium-, and wide-angle X-ray scattering, electron diffraction and tomography.
- Knowledge of biophysical techniques such as mass photometry, mass spectroscopy, differential scanning fluorimetry, high performance liquid chromatography, size exclusion chromatography, differential scanning calorimetry, isothermal titration calorimetry, bio-layer interferometry, and surface plasmon resonance.
- Experience in Bash shell scripting, Python, R, SQL, C++, JavaScript or other relevant programming languages.
- Project leadership experience.
- Experience with computational modelling and analysis of protein structures, and structure-based design of small molecule drugs, antibodies and vaccine.
About GSK LLP
GSK LLP is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive.
We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/immunology and oncology).
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive.
We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be.
A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing.
-
Cell Culture Scientist
7 days ago
Rockville, Maryland, United States GSK Full timeUnlock Your Potential in Structural BiologyAt GSK, we're pushing the boundaries of scientific innovation to create impactful medicines and vaccines. As a Research Scientist - Cell Culture, you'll be part of our US Structural Biology Center of Excellence (CoE) in Cambridge, MA, where you'll collaborate with talented experts to design vaccines and...
-
Senior Research Scientist
4 weeks ago
Rockville, Maryland, United States Office of Intramural Training & Education Full timeAbout the PositionWe are seeking a highly skilled Senior Research Scientist to contribute to our omics-based program supporting mRNA-based vaccine discovery efforts. As a key member of our Molecular Analytics team, you will be responsible for developing new assays suitable for candidate screening and mechanism of action studies.Key ResponsibilitiesDesign and...
-
Research Scientist
4 weeks ago
Rockville, Maryland, United States Kaigene, Inc Full timeJob DescriptionWe are seeking a highly motivated and experienced scientist to join our antibody production team at Kaigene, Inc. The successful candidate will be responsible for the design and execution of experiments aimed at the expression and purification of antibodies for therapeutic applications.Key Responsibilities:Design various formats of antibodies...
-
NGS Laboratory Technician/Scientist/Manager
1 month ago
Rockville, Maryland, United States Psomagen Inc Full timeJob OverviewPsomagen Inc. is a leading provider of genomic services, offering cutting-edge solutions for life science research and industry applications. We are seeking a highly skilled NGS Laboratory Technician/Scientist/Manager to join our team.This role will involve performing day-to-day NGS experiments, including sample preparation, library preparation,...
-
Senior Laboratory Scientist
4 weeks ago
Rockville, Maryland, United States Psomagen Inc Full timeJob Title: Senior Laboratory ScientistJob SummaryWe are seeking a highly motivated and experienced Senior Laboratory Scientist to join our microbiome product development team at Psomagen Inc.Key ResponsibilitiesDevelop and maintain bioinformatics pipelines for microbiome data analysisCurate and construct microbiome databases for test validationWork closely...
-
NGS Laboratory Technician/Scientist/Manager
4 weeks ago
Rockville, Maryland, United States Psomagen, Inc. Full timeJob Summary: We are seeking a highly skilled NGS Laboratory Technician/Scientist/Manager to join our team at Psomagen, Inc. The successful candidate will be responsible for performing day-to-day NGS experiments, including sample preparation, library preparation, and instrument operation. Responsibilities:Operate laboratory equipment, record data, and perform...
-
Senior Bioinformatics Scientist
4 weeks ago
Rockville, Maryland, United States Psomagen, Inc. Full timeAbout the RoleWe are seeking a highly motivated Senior Bioinformatics Scientist to lead the development, management, and improvement of analysis pipelines for Next-Generation Sequencing (NGS) services at Psomagen, Inc.The ideal candidate will take ownership of the development, management, and improvement of analysis pipelines for NGS services, ensuring the...
-
Senior Data Scientist
1 month ago
Rockville, Maryland, United States BioSpace, Inc. Full timeJob Title: Senior Data ScientistAt BioSpace, Inc., we are seeking a highly skilled Senior Data Scientist to join our team. As a Senior Data Scientist, you will be responsible for designing and developing structured, vectorized Python code that leverages best practice coding methodologies. You will lead efforts to source, import, and integrate new supply...
-
Senior Bioinformatics Scientist
4 weeks ago
Rockville, Maryland, United States Psomagen Inc Full timeJob OverviewPsomagen Inc. is a leading biotechnology company that provides cutting-edge genomic services through next-generation and Sanger sequencing with data analysis services for applications in basic research and clinic diagnostics.We are seeking a highly motivated Senior Bioinformatics Scientist to lead the development, management, and improvement of...
-
Computational Genomics Specialist
1 month ago
Rockville, Maryland, United States Guidehouse Full timeJob Opportunity:Guidehouse is seeking a highly skilled Computational Genomics Specialist to join our team. This is a full-time position with a competitive salary range of $100,200.00-$150,200.00.About the Role:We are looking for a talented individual to provide support to the National Institutes of Health (NIH) as a Genomics Specialist, Transcriptomics. The...
-
Senior Computational Biologist
4 weeks ago
Rockville, Maryland, United States Guidehouse Full timeJob SummaryWe are seeking a highly skilled Senior Computational Biologist to join our team at Guidehouse. The successful candidate will have expertise in computational biology and bioinformatics, with a strong background in genomics and molecular biology.Key ResponsibilitiesImplement, design, develop, and innovate current and emerging computational biology...
-
Computational Genomics Specialist
4 weeks ago
Rockville, Maryland, United States Guidehouse Full timeJob Summary:Guidehouse is seeking a highly skilled Computational Genomics Specialist to provide support to the National Institutes of Health (NIH).About the Role:This is a full-time position with Guidehouse, and it is on-site in Rockville, MD. As a Computational Genomics Specialist, you will be responsible for implementing, designing, developing, and...
-
Computational Genomics Specialist
4 weeks ago
Rockville, Maryland, United States Guidehouse Full timeJob Title: Computational Genomics SpecialistGuidehouse is seeking a highly skilled Computational Genomics Specialist to join our team. As a key member of our scientific research and analysis group, you will provide support to the National Institutes of Health (NIH) in the areas of bioinformatics and computational biosciences.Key Responsibilities:Implement,...
-
Branch Chief
4 weeks ago
Rockville, Maryland, United States United States Government Full timeJob SummaryWe are seeking a highly skilled and experienced Branch Chief to lead our team of engineers and scientists in the management and oversight of research and technical assistance programs. The successful candidate will be responsible for directing, leading, and managing a diverse technical staff in mission-critical programs with competing deadlines,...
-
Senior Project Manager
1 month ago
Rockville, Maryland, United States Foundation of the NIH Full timeAbout the OpportunityThe Foundation for the National Institutes of Health (FNIH) is seeking a highly skilled Senior Project Manager to lead large, multistakeholder public-private research collaborations focused on translational science across multiple disease areas. As a key member of the Science Partnerships team, you will be responsible for managing...
-
Clinical Laboratory Scientist
4 weeks ago
Rockville, Maryland, United States Psomagen Inc Full timeJob DescriptionPsomagen, Inc. is a leading CLIA-certified laboratory specializing in Next-Generation Sequencing (NGS) based high complexity tests. We are dedicated to providing cutting-edge genomic services to our clients, ensuring the highest standards of quality and compliance.The successful candidate will play a critical role in designing and implementing...
-
Associate Director RWE Pharmacoepidemiology
1 month ago
Rockville, Maryland, United States Axle Full timeJob OpportunityAxle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and...
-
Principal Scientist, Structural Biology
2 weeks ago
Rockville, United States GlaxoSmithKline Full timePrincipal Scientist, Structural BiologyAt GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.We believe the Greater Boston area is an important hub for...
-
Principal Scientist, Antigen Characterization
2 weeks ago
Rockville, United States GSK Full timeSite Name: USA - Massachusetts - Cambridge, Rockville Vaccines Posted Date: Oct 13 2024 Principal Scientist, Antigen Characterization This role qualifies for an enhanced Employee Referral Bonus in the amount of $3,500. At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is...
-
NGS Laboratory Technician/Scientist/Manager
4 weeks ago
Rockville, Minnesota, United States Psomagen, Inc. Full timeJob Summary:Psomagen, Inc. is seeking a highly skilled NGS Laboratory Technician/Scientist/Manager to join our team. The successful candidate will be responsible for performing day-to-day NGS experiments, including sample preparation, library preparation, and instrument operation. This is a challenging and rewarding role that requires strong molecular...
-
Data Scientist
2 weeks ago
Rockville, United States Axle Full timeJob DescriptionJob Description(ID: 2024-6083)Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management,...
-
Rockville, United States GlaxoSmithKline Full timeWithin the Analytical Development US, Expert Scientist, Mass Spec and Spectrophotometry (Biophysical Characterization) will serve as Subject Matter Expert (SME) in LC-MS and biophysical analysis of vaccine antigens. The scientist will be responsible for characterizing antigens and their interactions using Mass Spec and an array of biophysical and traditional...
-
Software Architect, Principal
1 week ago
Rockville, United States LCG, Inc. Full timeLocation: DC/Metro Area Required Clearance: Ability to obtain Public Trust LCG is a minority-owned technology consulting firm that has been a trusted partner to more than 40 federal agencies, including 21 of the 27 Institutes and Centers (ICs) at the National Institutes of Health (NIH). For over 30 years, LCG has brought digitization and innovation to the...
-
ROCKVILLE, United States Guidehouse Full timeJob Family:Scientific Research & Analysis (Digital)Travel Required:Up to 10%Clearance Required:NoneWe are currently searching for a computational biologist with expertise in Human Transcriptomics to provide support to the National Institutes of Health (NIH). This opportunity is a full-time position with Guidehouse that can be performed remotely while...
-
Content Marketing Manager
1 month ago
Rockville, United States Federation of American Societies for Experimental Biology (FASEB) Careers Full timePosition Title: Content Marketing ManagerReports to: Executive DirectorStatus: Part-time (15 hours/week), Non-exempt statusLocation: Rockville, Maryland, In Office on Tuesdays and WednesdaysSalary: $35-40/hour, depending on experienceDate: September 23, 2024About AAAThe American Association for Anatomy (AAA) is the professional home for an international...
-
Computational Genomics Specialist – Transcriptomics
2 months ago
ROCKVILLE, United States Guidehouse Full timeJob Family:Scientific Research & Analysis (Digital)Travel Required:Up to 10%Clearance Required:NoneWe are currently searching for a Genomics Specialist, Transcriptomics to provide support to the National Institutes of Health (NIH). This opportunity is a full-time position with Guidehouse, and it is on-site in Rockville, MD.What You Will Do:Implement, design,...
-
Manager, Communications
1 month ago
Rockville, United States American Association of Immunologists Full timeThe American Association of Immunologists (AAI) is seeking an accomplished individual to fill the newly established position of Communications Manager. AAI is at a pivotal juncture in its illustrious history, with a firm commitment from its leadership to deepen engagement with existing members and attract new ones. We aim to promote greater awareness among...
-
Technical Quality Specialist
1 week ago
Rockville, United States Kaiser Permanente Full timeJob Summary:Under the direction of the Department Director or Manager, formulate, implement and direct programs, policies and procedures which assure quality and standardization of departmental technical services in all Mid-Atlantic Region Laboratories. Act as region-wide technical advisor for laboratory personnel and Mid-Atlantic Permanente Clinicians. in...
-
Technical Quality Specialist
1 week ago
Rockville, United States Kaiser Permanente Full timeJob Summary: Under the direction of the Department Director or Manager, formulate, implement and direct programs, policies and procedures which assure quality and standardization of departmental technical services in all Mid-Atlantic Region Laboratories. Act as region-wide technical advisor for laboratory personnel and Mid-Atlantic Permanente Clinicians. in...
-
Communications Manager
3 weeks ago
Rockville, United States American Association of Immunologists Full timeAre you a passionate communicator with an interest in science and immunology? The Communications team at the American Association of Immunologists are looking for a new Communications Manager to lead on science, press and membership communications. Working with the Communications Director, you will help shape how we communicate with the public the...
-
Communications Manager
1 month ago
Rockville, United States The American Association of Immunologists Full timeAre you a passionate communicator with an interest in science and immunology? The Communications team at the American Association of Immunologists are looking for a new Communications Manager to lead on science, press and membership communications. Working with the Communications Director, you will help shape how we communicate with the public the...
-
Account Manager III, US
3 weeks ago
Rockville, United States Meso Scale Discovery Full timeDescription POSITION SUMMARY: The Account Manager III is responsible for managing a defined geographic region with a focus on meeting sales revenue objectives while maintaining and building customer relationships. This position will focus on obtaining customers in the areas of academia, industrial, contract research accounts and similar opportunities. DUTIES...
-
Account Manager III, US
3 weeks ago
Rockville, United States Meso Scale Discovery Full timeDescription POSITION SUMMARY: The Account Manager III is responsible for managing a defined geographic region with a focus on meeting sales revenue objectives while maintaining and building customer relationships. This position will focus on obtaining customers in the areas of academia, industrial, contract research accounts and similar opportunities. DUTIES...
-
Communications Manager
1 month ago
Rockville, United States American Association of Immunologists Full timePosition: Communications ManagerOrganization: AAI (American Association of Immunologists)Location: Rockville, MD Are you a passionate communicator with an interest in science and immunology? The Communications team at the American Association of Immunologists are looking for a new Communications Manager to lead on science, press and membership...
-
Communications Manager
1 month ago
Rockville, United States American Association of Immunologists Careers Full timePosition: Communications ManagerOrganization: AAI (American Association of Immunologists)Location: Rockville, MD Are you a passionate communicator with an interest in science and immunology? The Communications team at the American Association of Immunologists are looking for a new Communications Manager to lead on science, press and membership...
-
Communications Manager
1 month ago
Rockville, United States American Association of Immunologists Careers Full timePosition: Communications ManagerOrganization: AAI (American Association of Immunologists)Location: Rockville, MD Are you a passionate communicator with an interest in science and immunology? The Communications team at the American Association of Immunologists are looking for a new Communications Manager to lead on science, press and membership...
-
Communications Manager
1 month ago
Rockville, United States American Association of Immunologists Careers Full timePosition: Communications ManagerOrganization: AAI (American Association of Immunologists)Location: Rockville, MD Are you a passionate communicator with an interest in science and immunology? The Communications team at the American Association of Immunologists are looking for a new Communications Manager to lead on science, press and membership...