Principal Scientist, Structural Biology

4 weeks ago


Rockville, Maryland, United States GSK LLP Full time

About the Role

We are seeking a highly motivated and experienced Principal Scientist to join our team at GSK LLP. As a Principal Scientist, you will be responsible for leading research projects in structural biology, protein crystallography, and biophysics to support the development of vaccines and medicines.

Key Responsibilities

  • Design and conduct complex experiments to determine the three-dimensional structures of proteins and protein complexes using techniques such as X-ray crystallography and cryo-electron microscopy.
  • Collaborate with cross-functional teams to develop and implement new methods and protocols related to structural biology and protein chemistry.
  • Interpret results of structural and biophysical experiments to inform structure-based drug design and vaccine development.
  • Manage and maintain state-of-the-art laboratory equipment and ensure compliance with safety procedures and regulations.
  • Author and present research findings and updates in internal reports, project meetings, and external scientific meetings.

Requirements

  • PhD in a structural biology related field with a focus on protein crystallography.
  • Three or more years of experience with protein chemistry and structural biology.
  • Ability to design and conduct complex experiments and interpret results.
  • Three or more years of experience in macromolecular crystallography, including the principles and techniques used in the field.
  • Three or more years of laboratory experience in protein expression, biochemistry, protein crystallization, and data collection.
  • Three or more years of experience using and maintaining crystallography equipment.
  • Three or more years of experience using crystallography software tools for data processing, structure solution, refinement, and analysis.

Preferred Qualifications

  • Post-Doctoral or industrial research experience in protein biochemistry, macromolecular crystallography, molecular modelling, molecular biology, computational biology, or other related discipline.
  • Experience with other macromolecular structural determination methods such as cryo-EM, small-, medium-, and wide-angle X-ray scattering, electron diffraction and tomography.
  • Knowledge of biophysical techniques such as mass photometry, mass spectroscopy, differential scanning fluorimetry, high performance liquid chromatography, size exclusion chromatography, differential scanning calorimetry, isothermal titration calorimetry, bio-layer interferometry, and surface plasmon resonance.
  • Experience in Bash shell scripting, Python, R, SQL, C++, JavaScript or other relevant programming languages.
  • Project leadership experience.
  • Experience with computational modelling and analysis of protein structures, and structure-based design of small molecule drugs, antibodies and vaccine.

About GSK LLP

GSK LLP is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive.

We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive.

We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be.

A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing.



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