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Expert Scientist, Mass Spec and Spectrophotometry

2 months ago

Rockville, United States GlaxoSmithKline Full time

Within the Analytical Development US, Expert Scientist, Mass Spec and Spectrophotometry (Biophysical Characterization) will serve as Subject Matter Expert (SME) in LC-MS and biophysical analysis of vaccine antigens. The scientist will be responsible for characterizing antigens and their interactions using Mass Spec and an array of biophysical and traditional protein chemistry tools. The role is focused on providing a structure-function understanding to support assays development activities for all stages of vaccine development.


Why you?Basic Qualifications:

We are looking for professionals with these required skills:

  • PhD or Master's with specialization in Mass Spectroscopy
  • At least 6+ years of experience in industry/academic (pharmaceutical or biotech) setting working on characterizing diverse molecules (proteins, carbohydrates, nucleotides) by mass spectroscopy and spectrophotometry
  • Experience with analytical development for vaccine/ biotherapeutic candidates.
  • In-depth understanding of protein chemistry and strong laboratory skills
  • Hands-on experience with qualitative and quantitative characterization of proteins and nucleotides using MS platform (Glycan profiling, peptide mapping, intact mass).
Preferred Qualifications:

If you have the following characteristics, it would be a plus:

  • Familiarity with HDX for higher order structure determination, epitope / paratope mapping.
  • Knowledge and experience with Quality by Design, Process Analytical Technology, CMC, regulatory filling, and managing CMC program.
  • Experience with liquid handling systems, and robotic automation.
Why GSK?

Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

  • Agile and distributed decision-making - using evidence and applying judgement to balance pace, rigour and risk, governance and control, managing ambiguity and paradox.
  • Managing individual performance.
  • Creating a performance culture and driving results, prioritisation, execution, delivering performance.
  • Setting strategic direction and leading ongoing organisational transformation.
  • Building a resilient organisation.
  • Building strong relationships and collaboration in service of common goals, engaging the organisation and building trusted external networks for mutual benefit.
  • Managing P&L and capital allocation.
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