Principal Scientist, Antigen Characterization

2 weeks ago

Rockville, United States GSK Full time
Site Name: USA - Massachusetts - Cambridge, Rockville Vaccines
Posted Date: Oct 13 2024

Principal Scientist, Antigen Characterization

This role qualifies for an enhanced Employee Referral Bonus in the amount of $3,500.

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.

The US Structural Biology Center of Excellence (CoE) at GSK will apply the full range of structural biology, protein biochemistry, and computational tools to design vaccines as well as to antibodies, biologics, and small molecules. This position is hosted in the Antigen Characterization Lab within CoE. The main function of the lab is to bridge the design with preclinical efficacy, by providing data-driven decisions for candidate selection.

We’re looking for a passionate and highly motivated scientist to join our lab. You will be at the center of our protein expression, purification, biochemical, biophysical and structural characterization operations. You will need to demonstrate scientific knowledge in the workflow from gene-to-structure and the ability to troubleshoot problems in a timely fashion. You are also expected to be innovative by developing new assays to provide insight on tough targets such as multi-component complexes, virus-like particles, and membrane-bound proteins. Your results and workflow are expected to be transferable to GMP productions, requiring active collaboration with a diverse team to address key challenges close to the clinical stage.

This lab-based position will initially be located at GSK’s Rockville site in Maryland from 2024 to late 2025, and will permanently move to Cambridge, Massachusetts afterwards.

Key Responsibilities:

  • Develop design strategies and screening assays to support vaccine or medicine lead identification and validation for project progression.
  • Perform molecular biology, protein production, and biochemical, biophysical characterization to identify suitable conditions and deliver reagents for structural and animal studies.
  • Provide scientific insight for projects based on experimental results and literature information.
  • Timely document your work to support reagent and intellectual property needs by other groups.
  • Author, present, and publish research findings internally or externally.
  • Share management and maintenance duties of lab equipment.
  • Stay current with the latest developments and techniques in the field and mentor other researchers as needed.

Basic Qualifications:

  • PhD degree in a protein biochemistry or structural biology related field with 3+ years of post-doc or relevant industry experience.
  • Minimum of 5 years of laboratory experience in protein biochemistry.
  • Two or more years in construct and protein expression optimization with multiple host systems such as bacterial, yeast, insect, and mammalian cells.
  • Two or more years of experience in protein purification with chromatography systems.
  • Two or more years of experience in conducting biochemical, biophysical, and high-resolution structural experiments and interpreting the results.

Preferred Qualifications:

  • Demonstrated experience as a major contributor for novel high-resolution structures in recent years.
  • Demonstrated ability to work independently and strong communication skills to present findings and collaborate with the team.
  • Experience in antigen designs based on structural analysis.
  • Experience with biochemical and biophysical high-throughput screening assay development.
  • Industrial research experience in molecular biology, protein biochemistry, macromolecular crystallography, cryo-EM, or other related disciplines.

The annual base salary for new hires in this position ranges from $111,350 to $150,650, considering factors including work location, candidate’s skills, experience, education level, and market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share-based long-term incentive program, which is dependent on the level of the role. Available benefits include healthcare and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

GSK is a global biopharma company with a special purpose – to unite science, technology, and talent to get ahead of disease together. Our success absolutely depends on our people. We want GSK to be a place where people feel inspired, encouraged, and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. If you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

If you require accommodation or assistance to apply for a job at GSK, please contact the GSK Service Centre.

GSK is an Equal Opportunity Employer and adheres to Affirmative Action principles.

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