Senior Scientist Chemical Biology and Peptide Macrocycles

1 week ago

Pasadena, California, United States Eli Lilly and Company Full time

At Eli Lilly and Company, we are dedicated to discovering and developing innovative medicines that improve the lives of people around the world. We are seeking a highly skilled and experienced Senior Scientist to join our team in the area of Chemical Biology and Peptide Macrocycles.

About the Role:

The successful candidate will be responsible for leading efforts in the development of oral macrocycles, including initiating and leading new projects, formulating strategy, and executing on that strategy to accelerate from target to hit identification and lead optimization towards candidate declaration. This role will also involve shared accountability on development and execution of biochemistry strategy to support the portfolio, as well as individual projects.

Key Responsibilities:

  • Lead group in efforts in oral macrocycles, including initiating and leading new projects, formulating strategy, and executing on that strategy.
  • Shared accountability on development and execution of biochemistry strategy to support the portfolio, as well as individual projects.
  • Responsible for resourcing decisions in chemistry across portfolio projects.
  • Balance science and the business of science by delivering the small and large molecule portfolio through responsible planning, execution, and completion of projects.
  • Work on and lead molecule engineering efforts from lead identification to lead optimization all the way to phase 1b and beyond.
  • Take on dedicated molecular engineering efforts towards targets of high conviction and utilize speed and prioritization to advance synthetic efforts.
  • Learn about and enhance the platform technology efforts.
  • Inspire people to collaborate in inventing great medicines by removing barriers, committing to high quality scientific hypotheses, and accelerating where possible.
  • Keep safety as a top priority at all times, striving toward a proactive safety culture.
  • Be an advocate for diversity and inclusion in our recruiting, retaining and developing scientists.

Requirements:

  • PhD or post doctoral degree in chemistry or synthetic chemistry or peptide chemistry or related field with significant successful drug discovery and development experience.
  • Deep knowledge as well as mastery of the latest developments in oral macrocycles and macrocyclic peptides.
  • Understand the challenges and has the ability to initiate and lead new oral macrocycles projects, can formulate strategy and execute on the strategy organizing team efforts for deep technical development and to accelerate from target to hit identification and lead optimization towards candidate declaration.
  • Significant knowledge in oral macrocycles, based on library-based screening technologies including at least one of OBOC, solution-phase, AS/MS, mRNA display or related peptide library screening technologies.
  • Proven track record of either library-base screening or lead optimization efforts, and ideally both in oral macrocycles.
  • Familiarity with state of the art in computational and structural efforts for hit identification and lead optimization in macrocyclic peptides.
  • Must have deep scientific expertise and demonstrated ability to lead a team of scientists from within therapeutic/functional areas with a proven track record of delivering candidate molecules into clinical testing.
  • Must be an excellent team player, strong attention to detail, strong problem-solving skills, a high level of learning agility, with the ability to lead within a globally matrixed organization and across functions.

Additional Skills/Preferences:

  • Great understanding of computational and AI/machine learning techniques used for the development and engineering of oral macrocyclic peptide medicines.
  • Candidate will understand the whole drug discovery process including lead generation and lead optimization and will partner with cross functional groups including other areas within Medicine Innovation Hub, therapeutic areas, ADME, nonclinical safety assessment and PK/PD.
  • Demonstrated deep expertise in drug development with a proven track record of success.
  • Ability to think strategically, actively identifying gaps in competencies or capabilities within the organization and taking initiative to drive continuous improvement across Protomer.

Additional Information:

  • Some domestic and international travel is anticipated and expected.

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