Senior Director, DMPK
1 day ago
Bicycle Therapeutics is seeking a Senior Director of Drug Metabolism and Pharmacokinetics (DMPK) to lead a small team of DMPK scientists supporting multiple projects from target identification through to candidate selection and regulatory submission.
Key Responsibilities- Provide DMPK scientific leadership across all stages of the portfolio.
- Oversee the quality and performance of all DMPK activities, including interactions with external CROs and internal project stakeholders.
- Work collaboratively with other core disciplines to support compound progression based on optimizing DMPK properties.
- Integrate data from multiple sources to inform understanding of bicyclic peptide distribution, metabolism, and excretion.
- Work closely with in-vivo pharmacology to design experiments to understand preclinical pharmacokinetic/pharmacodynamic (pk/pd) relationships.
- Work closely with the discovery team and regulatory team to author and review DMPK-related IND documents.
- Manage DMPK budgets for CROs and monitor CROs to ensure delivery of quality data on time.
- Support leadership of the Quantitative Pharmacology group and junior staff development.
- PhD in a relevant scientific discipline, such as drug metabolism, pharmacology, or pharmaceutical sciences.
- Significant experience working on DMPK drug discovery and/or development projects with a track record of successful delivery.
- In-depth understanding of DMPK science with additional knowledge of related disciplines.
- Demonstrated expertise in DMPK problem-solving across drug discovery.
- Ability to adapt working style to suit different cultures and partner expectations in both remote and office-based environments.
- Excellent organization and communication skills, both written and oral, with the ability to influence.
- Flexible working environment
- Competitive rewards, including an annual company bonus
- Medical, dental, and vision insurance for eligible employees and their families, with 100% of premiums covered by the Company
- Health and Dependent Care Flexible Spending Accounts
- 401(k) plan with a 4% Company match and immediate vesting
- Eligibility to accrue up to 23 paid time off days per full year worked, plus the option to buy up to 5 additional days
- Employee assistance program
- Employee recognition schemes
- 10 Company holidays
- Competitive Family Leave Policy
- Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
All your information will be kept confidential according to EEO guidelines.
Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, color, gender, sexual orientation, age, disability status, marital status, or veteran status.
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