Scientist II, Bioassay Development Specialist

3 days ago

South San Francisco, California, United States AbbVie Full time
Job Summary

Absorbent minds are sought to join the Bioassay group at AbbVie's South San Francisco, CA location. As a Scientist II, you will play a pivotal role in the development and evaluation of novel biologics for clinical drug candidates across various therapeutic areas.

Key Responsibilities
  • Develop and optimize complex cell-based functional assays (bioassays) and target-binding potency assays for therapeutic antibodies, complex antibody variants, and antibody-drug conjugates (ADCs).
  • Perform potency testing and characterization to support drug development activities and IND submissions.
  • Qualify/validate/transfer potency methods to external partners and author technical documents (e.g. methods, protocols and reports) to enable regulatory submission.
  • Collaborate with the analytical development team to elucidate structure/function molecular characterization and interact cross-functionally with teams from discovery, CMC, QC, and more.
  • Develop new techniques, explore new approaches and technologies, perform troubleshooting and optimization experiments, and present your work to various cross-functional teams.
Requirements
  • Degree in chemical biology, biochemistry, cell/molecular biology, or a related field with typically 7+ years (BS) or 5+ years (MS) of relevant industry experience.
  • Demonstrated experience with current binding potency assay approaches, such as ELISA, flow cytometry, and/or other binding potency assay platforms (i.e. TR-FRET, Octet, etc).
  • Demonstrated experience with current bioassay methodologies, such as cytotoxicity assays, reporter gene assays, proliferation assays, primary cell assay and/or ADCC.
  • Experience performing cell-based assays, mammalian cell culture and/or target binding potency assays, preferably in a bioassay development group within a Chemistry Manufacturing and Controls (CMC) organization.
  • Experience using PRISM, PLA, Softmax Pro, or similar data analysis software.
  • Demonstrated abilities to quickly learn new skills, think independently, and work collaboratively in teams.
What We Offer

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.

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